List of works - Matthew K. Higgins

A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor

scientific article

A helminth-derived suppressor of ST2 blocks allergic responses

scientific article published on 18 May 2020

A new site of attack for a malaria vaccine

scientific article published in April 2018

A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies

scientific article published on 3 December 2012

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

scientific article published on 12 March 2020

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

scientific article published on 23 May 2019

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'.

scientific article published on 30 January 2017

Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas

scientific article published on 30 January 2020

Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells

scientific article published on February 2003

Carbohydrate binding molecules in malaria pathology.

scientific article published on 23 July 2010

Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants

scientific article published on 15 November 2010

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

scientific article published on 23 December 2015

Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5

scientific article published on 02 August 2019

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

scientific article published on 11 June 2019

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

scientific article

Evolution of the primate trypanolytic factor APOL1

scientific article

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor

scientific article published on 15 April 2016

Fragments of bacterial endoglycosidase s and immunoglobulin g reveal subdomains of each that contribute to deglycosylation.

scientific article published on 25 March 2014

Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

scientific article

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens.

scientific article published on 4 June 2019

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

scientific article published on 13 June 2019

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.

scientific article

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum

scientific article

In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum.

scientific article published on 19 February 2018

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

scientific article published in 2022

Malaria Vaccines: Recent Advances and New Horizons

scientific article published on 11 July 2018

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes

scientific article published on 04 September 2013

Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding.

scientific article

Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.

scientific article published on 6 January 2013

Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains

scientific article published on May 2002

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

O-h what a surprise

scientific article published on 01 August 2018

Oligomerization and activation of the FliI ATPase central to bacterial flagellum assembly.

scientific article published on June 2003

On the state of crystallography at the dawn of the electron microscopy revolution

scientific article

One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

scientific article published on 17 January 2017

Overproduction, purification and crystallization of PfTic22, a component of the import apparatus from the apicoplast of Plasmodium falciparum

scientific article published on 23 February 2012

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

scientific article

Production, quality control, stability, and potency of cGMP-produced RH5.1 protein vaccine expressed in S2 cells

scientific article published on 17 August 2018

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

scientific article published on 2 September 2024

Recoverin Binds Exclusively to an Amphipathic Peptide at the N Terminus of Rhodopsin Kinase, Inhibiting Rhodopsin Phosphorylation without Affecting Catalytic Activity of the Kinase

scientific article published in Journal of Biological Chemistry

Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.

scientific article published on 16 December 2013

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families

scientific article published on 19 February 2014

Severe malaria is associated with parasite binding to endothelial protein C receptor

scientific article

Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax

scientific article published in 2023

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

scientific article published on 10 July 2020

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody ⬇️

scientific article published on 27 May 2019

Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor

scientific article

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

scientific article published in Nature Communications

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria

scientific article

Structural insights into chondroitin sulfate binding in pregnancy-associated malaria ⬇️

scientific article published on October 1, 2010

Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

scientific article published on 16 September 2019

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

scientific article

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.

scientific article

Structure of the trypanosome haptoglobin–hemoglobin receptor and implications for nutrient uptake and innate immunity ⬇️

scientific article published on January 14, 2013

Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion

scientific article published on 21 October 2019

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

scientific article published on March 2017

The PfRCR complex bridges malaria parasite and erythrocyte during invasion

scientific article published on 20 December 2023

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

scientific article

The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site

scientific article published on 08 September 2020

The structural basis for CD36 binding by the malaria parasite

scientific article

The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

scientific article published on 20 May 2017

The structure of serum resistance-associated protein and its implications for human African trypanosomiasis

scientific article

Three's company: component structures bring a closer view of tripartite drug efflux pumps.

scientific article

Tic22 Is an Essential Chaperone Required for Protein Import into the Apicoplast

scientific article

List of works by Matthew K. Higgins

A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor

A helminth-derived suppressor of ST2 blocks allergic responses

A new site of attack for a malaria vaccine

A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'.

Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas

Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells

Carbohydrate binding molecules in malaria pathology.

Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

Evolution of the primate trypanolytic factor APOL1

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor

Fragments of bacterial endoglycosidase s and immunoglobulin g reveal subdomains of each that contribute to deglycosylation.

Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens.

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum

In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum.

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

Malaria Vaccines: Recent Advances and New Horizons

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes

Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding.

Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.

Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

O-h what a surprise

Oligomerization and activation of the FliI ATPase central to bacterial flagellum assembly.

On the state of crystallography at the dawn of the electron microscopy revolution

One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

Overproduction, purification and crystallization of PfTic22, a component of the import apparatus from the apicoplast of Plasmodium falciparum

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

Production, quality control, stability, and potency of cGMP-produced RH5.1 protein vaccine expressed in S2 cells

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

Recoverin Binds Exclusively to an Amphipathic Peptide at the N Terminus of Rhodopsin Kinase, Inhibiting Rhodopsin Phosphorylation without Affecting Catalytic Activity of the Kinase

Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families

Severe malaria is associated with parasite binding to endothelial protein C receptor

Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody ⬇️

Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria

Structural insights into chondroitin sulfate binding in pregnancy-associated malaria ⬇️

Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.

Structure of the trypanosome haptoglobin–hemoglobin receptor and implications for nutrient uptake and innate immunity ⬇️

Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

The PfRCR complex bridges malaria parasite and erythrocyte during invasion

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site

The structural basis for CD36 binding by the malaria parasite

The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

The structure of serum resistance-associated protein and its implications for human African trypanosomiasis

Three's company: component structures bring a closer view of tripartite drug efflux pumps.

Tic22 Is an Essential Chaperone Required for Protein Import into the Apicoplast