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List of works by David E. Heinrichs

A Fluorescence Based-Proliferation Assay for the Identification of Replicating Bacteria Within Host Cells

scientific article published on 12 December 2018

A Heme-responsive Regulator Controls Synthesis of Staphyloferrin B in Staphylococcus aureus

scientific article published on 3 November 2015

An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

scientific article published on 09 June 2020

Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin.

scientific article

Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation

scientific article published on 04 September 2018

Characterization of dTDP-4-dehydrorhamnose 3,5-epimerase and dTDP-4-dehydrorhamnose reductase, required for dTDP-L-rhamnose biosynthesis in Salmonella enterica serovar Typhimurium LT2.

scientific article published in August 1999

Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus

scientific article

Characterization of the Heme Binding Properties ofStaphylococcus aureusIsdA†

article

Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine.

scientific article published on November 1993

Comparative and genetic analysis of the four sequenced Paenibacillus polymyxa genomes reveals a diverse metabolism and conservation of genes relevant to plant-growth promotion and competitiveness

scientific article

Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

scientific article

Crystal and solution structure analysis of FhuD2 from Staphylococcus aureus in multiple unliganded conformations and bound to ferrioxamine-B

scientific article

DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus

scientific article published on 11 January 2019

Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis

scientific article

Deferoxamine mesylate enhances virulence of community-associated methicillin resistant Staphylococcus aureus.

scientific article published on 22 September 2014

Demonstration of the functional role of conserved Glu-Arg residues in the Staphylococcus aureus ferrichrome transporter

scientific article

Demonstration of the iron-regulated surface determinant (Isd) heme transfer pathway in Staphylococcus aureus.

scientific article published in August 2008

Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus

scientific article published on 01 December 2012

Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA

scientific article published on 25 November 2019

Distribution of core oligosaccharide types in lipopolysaccharides from Escherichia coli.

scientific article published on March 2000

Evidence for siderophore-dependent iron acquisition in group B streptococcus.

scientific article

Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis, by heme, hemoglobin, and coculture with Staphylococcus aureus

scientific article

Haem recognition by a Staphylococcus aureus NEAT domain

scientific article

Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus

scientific article

Heme binding properties of Staphylococcus aureus IsdE.

scientific article published on 12 October 2007

Identification and characterization of fhuD1 and fhuD2, two genes involved in iron-hydroxamate uptake in Staphylococcus aureus.

scientific article

Identification of Key Determinants of Staphylococcus aureus Vaginal Colonization

scientific article published on 24 December 2019

Identification of a Positively Charged Platform in Staphylococcus aureus HtsA That Is Essential for Ferric Staphyloferrin A Transport

scientific article published on 28 July 2014

In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteins

scientific article published in July 2004

Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids.

scientific article published on 23 March 2015

Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus

scientific article

Inhibition of expression of a staphylococcal superantigen-like protein by a soluble factor from Lactobacillus reuteri

scientific article published in April 2006

Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination.

scientific article published on 26 September 2015

Involvement of major facilitator superfamily proteins SfaA and SbnD in staphyloferrin secretion in Staphylococcus aureus

scientific article published on 11 February 2015

Involvement of reductases IruO and NtrA in iron acquisition by Staphylococcus aureus.

scientific article published on 11 April 2015

Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane

scientific article published in October 1998

Iron Acquisition Strategies of Bacterial Pathogens.

scientific article published on April 2016

Iron acquisition by the haem-binding Isd proteins in Staphylococcus aureus: studies of the mechanism using magnetic circular dichroism

scientific article published on 01 December 2008

IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus

scientific article

Macrophage-driven nutrient delivery to phagosomal Staphylococcus aureus supports bacterial growth

scientific article published on 25 May 2020

Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica

scientific article published on October 1, 1998

Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus

scientific article published on 22 September 2009

Multiprotein Heme Shuttle Pathway in Staphylococcus aureus: Iron-Regulated Surface Determinant Cog-Wheel Kinetics

scientific article published on 01 October 2012

Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus

scientific article published on September 9, 2011

Population Analysis of Staphylococcus aureus Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia

scientific article published on 27 October 2020

Recent developments in understanding the iron acquisition strategies of gram positive pathogens

scientific article published on 09 April 2015

Receptor-interacting protein-2 deficiency delays macrophage migration and increases intracellular infection during peritoneal dialysis-associated peritonitis

scientific article published on 20 June 2008

Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

scientific article

Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter.

scientific article

Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus

scientific article

Role of lipase from community-associated methicillin-resistant Staphylococcus aureus strain USA300 in hydrolyzing triglycerides into growth-inhibitory free fatty acids

scientific article

SbnG, a citrate synthase in Staphylococcus aureus: a new fold on an old enzyme.

scientific article

SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.

scientific article

Siderophore-mediated iron acquisition in the staphylococci.

scientific article published on 26 September 2009

Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus

scientific article published on November 5, 2010

Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins

scientific article

Staphylococcus aureus Nonribosomal Peptide Secondary Metabolites Regulate Virulence

scientific article

Staphylococcus aureus Transporters Hts, Sir, and Sst Capture Iron Liberated from Human Transferrin by Staphyloferrin A, Staphyloferrin B, and Catecholamine Stress Hormones, Respectively, and Contribute to Virulence

scientific article published on March 14, 2011

Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages

scientific article published on 17 July 2018

Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

scientific article published on 14 October 2019

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

scientific article published in Nature Communications

Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor

scientific article

TCA cycle activity in Staphylococcus aureus is essential for iron-regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase

scientific article published on 15 April 2014

The N-acetylmannosamine transferase catalyzes the first committed step of teichoic acid assembly in Bacillus subtilis and Staphylococcus aureus.

scientific article published on 17 April 2009

The Staphylococci and Staphylococcal Pathogenesis

scientific article published on May 18, 2012

The assembly system for the lipopolysaccharide R2 core-type of Escherichia coli is a hybrid of those found in Escherichia coli K-12 and Salmonella enterica. Structure and function of the R2 WaaK and WaaL homologs.

scientific article published on April 1998

The assembly system for the outer core portion of R1- and R4-type lipopolysaccharides of Escherichia coli. The R1 core-specific beta-glucosyltransferase provides a novel attachment site for O-polysaccharides.

scientific article

The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus

scientific article published on 13 June 2019

The iron-regulated staphylococcal lipoproteins.

scientific article published on 04 April 2012

The role of FhuD2 in iron(III)-hydroxamate transport in Staphylococcus aureus. Demonstration that FhuD2 binds iron(III)-hydroxamates but with minimal conformational change and implication of mutations on transport

scientific article published on 26 September 2003

The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence

scientific article

The surreptitious survival of the emerging pathogen Staphylococcus lugdunensis within macrophages as an immune evasion strategy

scientific article published on 07 August 2018

The yjeQ gene is required for virulence of Staphylococcus aureus

scientific article

Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome.

scientific article published in June 2009

Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.

scientific article published on March 2002