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List of works by Nobuyuki Okamura

18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features.

scientific article published on 20 June 2016

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

scientific article published on 24 March 2011

18F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia

scientific article published on 01 September 2018

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.

scientific article published on 5 November 2015

2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients

scientific article published in April 2007

A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography.

scientific article

A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227.

scientific article published on 27 July 2011

A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.

scientific article published in January 2004

Advances in molecular imaging for the diagnosis of dementia

scientific article published on 29 July 2009

Advances in the development of tau PET radiotracers and their clinical applications

scientific article

Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET.

scientific article published on 28 November 2009

Amyloid and tau imaging, its present and future

scientific article published in January 2015

Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.

scientific article published on 16 June 2015

Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis.

scientific article published on 10 January 2014

Applied multimodal diagnostics in a case of presenile dementia.

scientific article

Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report

scientific article

Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies.

scientific article published on 26 February 2014

Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial

scientific article

Biomarkers in subjects with amnestic mild cognitive impairment

scientific article published in November 2003

Blocking histamine H(1) improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection.

scientific article published on 10 June 2008

Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus

scientific article published on 10 June 2012

Brain activity associated with dual-task management differs depending on the combinations of response modalities.

scientific article published on 7 August 2007

Brain histamine H1 receptor occupancy of loratadine measured by positron emission topography: comparison of H1 receptor occupancy and proportional impairment ratio

scientific article published on 01 March 2011

CSF phosphorylated tau protein and mild cognitive impairment: a prospective study

scientific article published in November 2000

Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis

scientific article published in January 2012

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.

scientific article

Cerebrospinal fluid amyloid beta(1-42) levels in the mild cognitive impairment stage of Alzheimer's disease

scientific article published in December 2001

Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans

scientific article published in October 1999

Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351.

scientific article published on 19 July 2016

Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia

scientific article published on 25 July 2012

Classification of dementias

scientific article

Clinical and biomarker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer's disease

scientific article published in November 2002

Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease

scientific article published in March 2002

Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology.

scientific article

Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology

scientific article published on 26 October 2012

Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.

scientific article published on 23 June 2009

Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease

scientific article

Differential diagnosis in Alzheimer's disease and dementia with Lewy bodies via VMAT2 and amyloid imaging

scientific article published on 17 January 2012

Discrete cortical regions associated with the musical beauty of major and minor chords.

scientific article

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351

scientific article

Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving

scientific article published in March 2008

Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.

scientific article

Erratum to: Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351

scientific article published on 01 January 2017

Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans.

scientific article published on 24 April 2013

Geriatric medicine, Japanese Alzheimer's disease neuroimaging initiative and biomarker development

scientific article

Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies

scientific article published in April 2000

Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study.

scientific article published in April 2012

Histamine H(1) receptors in patients with Alzheimer's disease assessed by positron emission tomography

scientific article published in January 2000

IgLON5: A case with predominant cerebellar tau deposits and leptomeningeal inflammation

scientific article published on 03 July 2018

Imaging Alzheimer's Disease: The Evolution of Biomarkers

Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.

scientific article

In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.

scientific article

In vivo assessment of vesicular monoamine transporter type 2 in dementia with lewy bodies and Alzheimer disease.

scientific article

In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265

scientific article published on 01 January 2011

In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease.

scientific article published on 11 February 2014

In vivo imaging of amyloid plaques in the brain

scientific article published in March 2004

In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133

scientific article

In vivo tau imaging: obstacles and progress

scientific article published in June 2014

In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.

scientific article

In-vivo imaging of amyloid plaques

scientific article published in May 2008

Influence of anesthesia on brain distribution of [(11)C]methamphetamine in monkeys in positron emission tomography (PET) study.

scientific article published in August 2001

Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research.

scientific article

Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography.

scientific article published on 13 October 2015

Mechanism of the histamine H(3) receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice

scientific article

Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice

scientific article published on 26 September 2009

Neural correlates of perceptual difference between itching and pain: a human fMRI study.

scientific article

Neuroanatomical correlates of low body weight in Alzheimer's disease: a PET study

scientific article

Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine

scientific article

Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography.

scientific article published on December 2010

Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.

scientific article published on 27 March 2014

Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease

scientific article

PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes

scientific article published on 11 September 2019

Pathobiology of Alzheimer's disease and biomarker development.

scientific article published on January 2010

Perfusion-Phase [18F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration

scientific article published on 28 September 2017

Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.

scientific article published in January 2014

Positron emission tomography evaluation of sedative properties of antihistamines ⬇️

scientific article published on April 27, 2011

Preclinical Evaluation of [(18)F]THK-5105 Enantiomers: Effects of Chirality on Its Effectiveness as a Tau Imaging Radiotracer.

scientific article published on 21 July 2015

Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil

scientific article published on 12 March 2009

Quantitative evaluation of tau PET tracers F-THK5351 and F-AV-1451 in Alzheimer's disease with standardized uptake value peak-alignment (SUVP) normalization

scholarly article by Jingyun Chen et al published July 2018 in European Journal of Nuclear Medicine and Molecular Imaging

Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain.

scientific article published on 9 May 2015

Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.

scientific article published in November 2005

Recent advances in the development of amyloid imaging agents.

scientific article published on January 2007

Relationship between effects of alcohol on psychomotor performances and blood alcohol concentrations

scientific article published on 01 July 2000

Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats.

scientific article published on 30 November 2010

Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward: a study of receptors gene knockout mice.

scientific article published in January 2009

Serum cholesterol and cerebrospinal fluid amyloid beta protein in Alzheimer's disease

scientific article published in December 2001

Sleep patterns and mortality among elderly patients in a geriatric hospital.

scientific article published in November 2000

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

scientific article

Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease

scientific article published on 23 December 2015

Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain.

scientific article published in March 2004

Synthesis and Characterization of ¹⁸F-Interleukin-8 Using a Cell-Free Translation System and 4-¹⁸F-Fluoro-L-Proline.

scientific article published on 7 January 2016

Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging.

scientific article published on 16 October 2013

Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine

scientific article published on 29 September 2011

Tau PET imaging in Alzheimer's disease

scientific article

Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions.

scientific article published on 19 September 2015

Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy

scientific article

The development and validation of tau PET tracers: current status and future directions

article

The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET).

scientific article published in December 2002

The neural correlates of driving performance identified using positron emission tomography.

scientific article published on 2 December 2004

Untangling tau imaging

scientific article

Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain.

scientific article published in February 2014

Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease.

scientific article published on 21 August 2010

[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.

scientific article published on 20 March 2015

[18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy.

scientific article published in January 2017

[18F]FDG-PET study in dementia with Lewy bodies and Alzheimer's disease

scientific article published in February 2001

[Molecular PET imaging for in vivo detection of amyloid in the human brain]

scientific article published on 01 November 2009

[Molecular imaging techniques for research on brain function using PET]

scientific article published on 01 November 2005

[¹⁸F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment

scientific article published on 01 April 2020

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