Search filters

List of works by Robertina Giacconi

+647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications

scientific article published on 30 January 2008

1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.

scientific article published on 18 April 2005

A Novel Zip2 Gln/Arg/Leu Codon 2 Polymorphism Is Associated with Carotid Artery Disease in Aging

scientific article published on 01 April 2008

A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio.

scientific article

Accumulation of cells with short telomeres is associated with impaired zinc homeostasis and inflammation in old hypertensive participants

scientific article published on 9 April 2009

Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

scientific article published on 20 November 2018

Assessment of gene-nutrient interactions on inflammatory status of the elderly with the use of a zinc diet score--ZINCAGE study

scientific article published on 15 May 2009

Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population

scientific article

Association of HERV-K and LINE-1 hypomethylation with reduced disease-free survival in melanoma patients

scientific article published on 30 October 2020

Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort

scientific article published on 4 December 2009

Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study

scientific article published in 2022

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

scientific article published on 13 November 2006

Cellular Senescence and Inflammatory Burden as Determinants of Mortality in Elderly People Until the Extreme old age

scientific article

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence.

scientific article published on 13 September 2017

Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation.

scientific article

Circadian rhythms of body temperature and locomotor activity in aging BALB/c mice: early and late life span predictors.

scientific article published on 28 January 2016

Comparison of intracellular zinc signals in nonadherent lymphocytes from young-adult and elderly donors: role of zinc transporters (Zip family) and proinflammatory cytokines.

scientific article

Diet (zinc)-gene interaction related to inflammatory/immune response in ageing: possible link with frailty syndrome?

scientific article published on 22 April 2010

Different age-related effects of thymectomy in myasthenia gravis: role of thymoma, zinc, thymulin, IL-2 and IL-6

scientific article published on 01 August 2000

Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by Omeprazole and Lansoprazole treatment

scientific article

Differential effects of in vitro zinc treatment on gene expression in peripheral blood mononuclear cells derived from young and elderly individuals.

scientific article published in December 2007

Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects.

scientific article published on 7 May 2009

Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc

scientific article published on 07 March 2012

Dysfunctional macrophages in Alzheimer Disease: another piece of the "macroph-aging" puzzle?

scientific article published on 5 August 2017

Effect of 6-month caloric restriction on Cu bound to ceruloplasmin in adult overweight subjects

scientific article published on 6 May 2015

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.

scientific article published in November 2015

Effects of interleukin-6 -174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing.

scientific article published on 2 February 2008

Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study.

scientific article

Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases.

scientific article published on 17 May 2015

Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats

scientific article published on 08 April 2020

FKBP5 rs4713916: A Potential Genetic Predictor of Interindividual Different Response to Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease in a Real-Life Setting

scientific article published on 24 April 2019

Frequency of Polymorphisms of Signal Peptide of TGF-beta1 and -1082G/A SNP at the Promoter Region of Il-10 Gene in Patients with Carotid Stenosis

article

Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy.

scientific article

In vivo effect of alpha-bisabolol, a nontoxic sesquiterpene alcohol, on the induction of spontaneous mammary tumors in HER-2/neu transgenic mice

scientific article published in January 2010

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy.

scientific article published on 12 February 2018

Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation

scientific article

Interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool in very old age.

scientific article

Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform

scientific article published in April 2003

Involvement of −308 TNF-α and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients

scientific article published on 01 October 2006

Is there a possible single mediator in modulating neuroendocrine-thymus interaction in ageing?

scientific article published on February 2013

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

scientific article

Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2.

scientific article

Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications

scientific article published on December 2011

Metallothionein (I+II) confers, via c-myc, immune plasticity in oldest mice: model of partial hepatectomy/liver regeneration

scientific article published in August 2003

Metallothionein Downregulation in Very Old Age: A Phenomenon Associated with Cellular Senescence?

Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?

scientific article

Metallothioneins (I+II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply

scientific article published in March 2002

Metallothioneins, longevity and cancer: Comment on “Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain”

article

Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply

scientific article published on 01 April 2003

Micronutrient (Zn, Cu, Fe)-gene interactions in ageing and inflammatory age-related diseases: implications for treatments

scientific article published on 31 January 2012

Micronutrient-gene interactions related to inflammatory/immune response and antioxidant activity in ageing and inflammation. A systematic review

scientific article published on 02 January 2014

Modulation of Genes Involved in Zinc Homeostasis in Old Low-Grade Atherosclerotic Patients Under Effects of HMG-CoA Reductase Inhibitors

article

Modulators of cellular senescence: mechanisms, promises, and challenges from in vitro studies with dietary bioactive compounds

scientific article

MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans

article

My Mind Project: the effects of cognitive training for elderly-the study protocol of a prospective randomized intervention study.

scientific article

Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc.

scientific article published in December 2005

Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response

scientific article

Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

scientific article published on 06 December 2019

Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population

scientific article published on 10 October 2009

Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine.

scientific article published on 14 August 2006

Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals.

scientific article

Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population

scientific article published in October 2006

Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects.

scientific article published on 19 June 2008

Recovery from mild Escherichia coli O157:H7 infection in young and aged C57BL/6 mice with intact flora estimated by fecal shedding, locomotor activity and grip strength

scientific article published on 21 December 2018

Serum copper to zinc ratio: Relationship with aging and health status.

scientific article published on 07 February 2015

Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: Relationship with metallothioneins

scientific article published on 01 October 2006

Speciation of trace elements in human serum by micro anion exchange chromatography coupled with inductively coupled plasma mass spectrometry

scientific article published on 13 November 2011

Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): influence of a zinc-enriched environment.

scientific article

The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people.

scientific article

The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing

scientific article published in April 2004

The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases

scientific article published in February 2005

The variations during the circadian cycle of liver CD1d-unrestricted NK1.1+TCR gamma/delta+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice

scientific article published in May 2004

Vitamin E-gene interactions in aging and inflammatory age-related diseases: implications for treatment. A systematic review

scientific article published on 11 January 2014

Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study.

scientific article

Zinc homeostasis in aging: two elusive faces of the same "metal".

scientific article published in January 2006

Zinc in elderly people: effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: a Zincage study.

scientific article published in April 2008

Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes

scientific article published on 04 September 2008

Zinc, infections and immunosenescence.

scientific article

Zinc, metallothioneins and immunosenescence.

scientific article published on 28 June 2010

Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach

scientific article published on 19 April 2011

Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study.

scientific article

Zinc-binding proteins (metallothionein and alpha-2 macroglobulin) and immunosenescence.

scientific article published on 9 October 2006

Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans.

scientific article

Zinc-bound metallothioneins as potential biological markers of ageing.

scientific article

Zinc: dietary intake and impact of supplementation on immune function in elderly.

scientific article published on 6 January 2012

l-Arginine normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury.

scientific article published on 6 June 2009

Paulina is supported by:

About Paulina

Help