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List of works by James S O'Donnell

A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy

scientific article

A microfluidic anti-Factor Xa assay device for point of care monitoring of anticoagulation therapy

scientific article published on 13 May 2013

A recurrent F8 mutation in Irish haemophilia A patients: evidence for a founder effect

scientific article published on 28 December 2007

A role for intravenous immunoglobulin in the treatment of Acquired Von Willebrand Syndrome associated with IgM gammopathy.

scientific article published on 22 November 2017

ABO blood group phenotypes and Plasmodium falciparum malaria: unlocking a pivotal mechanism.

scientific article published on January 2007

Acquired protein s deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange

scientific article published on 01 August 2003

Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells

scientific article

Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.

scientific article

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury

scientific article published on 17 June 2015

Advances in understanding the molecular mechanisms that maintain normal haemostasis

scientific article published on 28 March 2019

Age-related factor IX correction in symptomatic female carriers with haemophilia B Leyden.

scientific article

Antithrombin inhibition using nanobodies to correct bleeding in hemophilia

scientific article published on 25 March 2020

Beta-adrenergic receptor polymorphisms in patients with elevated factor VIII levels with venous thrombosis

scientific article published on 01 October 2003

Biological mechanisms underlying inter-individual variation in factor VIII clearance in haemophilia

scientific article published on 28 June 2020

Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function

scientific article published on 14 January 2019

Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis

scientific article published on 10 May 2005

Clinical utility gene card for: haemophilia A.

scientific article

Clinical utility gene card for: haemophilia B.

scientific article published on 25 January 2012

Clinical utility gene card for: von Willebrand disease

scientific article

Coagulation factor content of solvent/detergent plasma compared with fresh frozen plasma.

scientific article published in April 2003

Comparative study of Factor Xa fluorogenic substrates and their influence on the quantification of LMWHs

scientific article published on 24 October 2010

Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas

scientific article published on 7 August 2011

Comparison of the anticoagulant response of a novel fluorogenic anti-FXa assay with two commercial anti-FXa chromogenic assays.

scientific article published on 27 August 2011

Concentration-dependent roles for heparin in modifying liopolysaccharide-induced activation of mononuclear cells in whole blood

scientific article published on 01 March 2008

Correcting dominant-negative von Willebrand disease

scientific article published on 01 January 2021

Development of a fluorescent anti-factor Xa assay to monitor unfractionated and low molecular weight heparins.

scientific article published on 25 March 2010

Dissociation of ABH antigen expression from von Willebrand factor synthesis in endothelial cell lines.

scientific article published on June 2003

Does antithrombotic therapy improve survival in cancer patients?

scientific article

Effects of four commercially available factor Xa proteins on the fluorogenic anti-factor Xa assay when monitoring unfractionated heparin

scientific article published on 01 January 2012

Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy

scientific article

Elevated factor VIII levels and risk of venous thrombosis.

scientific article

Elevated plasma factor VIII levels in patients with venous thrombosis – Constitutional risk factor or secondary epiphenomenon?

scientific article published on 26 October 2011

Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities

scientific article

Engineering activated protein C to maximize therapeutic efficacy.

scientific article published on 03 August 2015

Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13.

scientific article published on 24 November 2009

Genotype at the Secretor blood group locus is a determinant of plasma von Willebrand factor level

scientific article published on 01 February 2002

Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis

scientific article

How I treat low von Willebrand factor levels

scientific article published on 21 December 2018

Human Umbilical Vein Endothelial Cells Differ from Other Endothelial Cells in Failing to Express ABO Blood Group Antigens

scientific article published on 01 November 2000

Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups

scientific article published on 09 April 2014

Increased thrombin generation potential in symptomatic versus asymptomatic moderate or severe carotid stenosis and relationship with cerebral microemboli

scientific article published on 17 July 2014

Laboratory assays of VWF activity and use of desmopressin trials in the diagnosis of VWD: a systematic review and meta-analysis

scientific article published in 2022

Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery

scientific article

Longitudinal assessment of thrombin generation potential in response to alteration of antiplatelet therapy after TIA or ischaemic stroke

scientific article published on 14 October 2012

Longitudinal assessment of von Willebrand factor antigen and von Willebrand factor propeptide in response to alteration of antiplatelet therapy after TIA or ischaemic stroke

scientific article published on 30 April 2014

Longitudinal bleeding assessment in von Willebrand disease utilizing an interim bleeding score

scientific article published in 2022

Low risk of inhibitor formation in haemophilia A patients following en masse switch in treatment to a third generation full length plasma and albumin-free recombinant factor VIII product (ADVATE®).

scientific article published on 8 March 2011

Management of Elective Procedures in Low von Willebrand factor patients in the LoVIC study

scientific article published on 21 December 2020

Marked elevation of thrombin generation in patients with elevated FVIII:C and venous thromboembolism

scientific article published on 01 December 2001

Mutation analysis of haemophilia B in the Irish population: increased prevalence caused by founder effect

scientific article

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

scientific article published on 23 August 2016

Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia.

scientific article

Physical activity levels and participation in sport in Irish people with haemophilia

scientific article published on 29 October 2009

Platelet factor 4 impairs the anticoagulant activity of activated protein C.

scientific article published on 6 January 2009

Platelet von Willebrand factor--structure, function and biological importance

scientific article published on 11 January 2010

Primary thromboprophylaxis for cancer patients with central venous catheters--a reappraisal of the evidence

scientific article

Primary thromboprophylaxis in the palliative care setting: a qualitative systematic review.

scientific article

Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation

scientific article published on 16 June 2009

Proteolytic inactivation of ADAMTS13 by thrombin and plasmin.

scientific article published on 23 September 2004

Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays

scientific article published on 28 July 2011

Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

scientific article published on 6 November 2009

Role of the Thrombelastograph as an adjunctive test in thrombophilia screening

scientific article published in April 2004

Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition

scientific article

Severe factor V deficiency and pregnancy - a role for solvent-detergent plasma?

scientific article

Significant gynecological bleeding in women with low von Willebrand factor levels

scientific article published on 01 July 2018

Solvent–detergent plasma as replacement therapy in a pregnant patient with factor V deficiency

scientific article published on 01 July 2004

Switching clotting factor concentrates: considerations in estimating the risk of immunogenicity.

scientific article published on 29 October 2013

Telehealth for delivery of haemophilia comprehensive care during the COVID-19 pandemic

scientific article published on 30 September 2020

The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology

scientific article

The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling.

scientific article published on 04 October 2011

The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity

scientific article

The relationship between ABO histo-blood group, factor VIII and von Willebrand factor.

scientific article

Third Åland islands conference on von Willebrand disease, 26-28 September 2012: meeting report.

scientific article

Thrombin generation in haemophilia A patients with mutations causing factor VIII assay discrepancy

scientific article published on 9 February 2010

Variation in anticoagulant composition regulates differential effects of prothrombin complex concentrates on thrombin generation

scientific article published on 9 September 2009

X-linked moyamoya syndrome associated with severe haemophilia A.

scientific article

von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearancein vivo

scientific article published on 13 April 2015

von Willebrand factor clearance - biological mechanisms and clinical significance

scientific article published on 01 October 2018

von Willebrand factor promotes wound healing

scientific article published on 01 June 2019

von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation

scientific article published in June 2006

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