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List of works by Alex Rafacho

A high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cells.

scientific article

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.

scientific article

Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats

scientific article published in October 2014

Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway.

scientific article published on 14 November 2009

Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

scientific article published on 17 September 2014

Cellular changes in the prostatic stroma of glucocorticoid-treated rats

scientific article published on 01 April 2008

Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation

scientific article published on 14 June 2018

Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion.

scientific article

Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells

scientific article published on 24 September 2018

Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice

scientific article published on 24 January 2019

Dexamethasone Administration During Late Gestation Has No Major Impact on Lipid Metabolism, but Reduces Newborn Survival Rate in Wistar Rats

scientific article published on 03 July 2018

Dexamethasone during pregnancy impairs maternal pancreatic β-cell renewal during lactation

scientific article published on 01 February 2019

Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats

scientific article published in May 2008

Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets

scientific article published on 01 May 2007

Disruption of glucose tolerance caused by glucocorticoid excess in rats is partially prevented, but not attenuated, by arjunolic acid.

scientific article published in October 2014

Effects of glucocorticoids and exercise on pancreatic β-cell function and diabetes development: comments on Beaudry and Riddel

scientific article published on 01 February 2014

Evaluation of lipid homeostasis in the late gestational period of rats exposed to dexamethasone.

scientific article published on 11 November 2015

Exercise training prevents hyperinsulinemia, muscular glycogen loss and muscle atrophy induced by dexamethasone treatment

scientific article published on 6 December 2009

Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats.

scientific article published in December 2015

Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance

scientific article

Functional and structural adaptations in the pancreatic α-cell and changes in glucagon signaling during protein malnutrition

scientific article published on 14 February 2012

Glargine vs. NPH insulin therapy in pregnancies complicated by diabetes: an observational cohort study

scientific article published on 07 April 2010

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes.

scientific article published on 30 September 2014

Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets

scientific article published on 30 October 2009

Glucose Homeostasis Is Not Affected in a Murine Model of Parkinson's Disease Induced by 6-OHDA

scientific article published on 01 January 2018

Glucose homeostasis in rats treated with 4-vinylcyclohexene diepoxide is not worsened by dexamethasone treatment.

scientific article published on 2 June 2016

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice.

scientific article published on 11 December 2017

Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats.

scientific article published on 17 June 2013

High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets

scientific article published on 21 January 2009

High-fat diet obesity associated with insulin resistance increases cell proliferation, estrogen receptor, and PI3K proteins in rat ventral prostate.

scientific article published on 22 March 2012

Higher insulin sensitivity and impaired insulin secretion in cachetic solid ehrlich tumour-bearing mice

scientific article published on 18 March 2014

Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme.

scientific article published on 16 September 2015

INGAP-PP up-regulates the expression of genes and proteins related to K+ ATP channels and ameliorates Ca2+ handling in cultured adult rat islets

scientific article published on 4 March 2008

Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose

scientific article published on 8 August 2017

Impact of Glucocorticoid Excess on Glucose Tolerance: Clinical and Preclinical Evidence

scientific article

Impact of glucocorticoid treatment before pregnancy on glucose homeostasis of offspring exposed to glucocorticoid in adult life

scientific article published on 14 October 2019

Implications of palmitoleic acid (palmitoleate) on glucose homeostasis, insulin resistance and diabetes.

scientific article

Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats.

scientific article published on 21 April 2008

Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid

scientific article published on 07 November 2011

Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats

scientific article published on 4 December 2009

JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats.

scientific article published on 28 September 2014

Leucine supplementation augments insulin secretion in pancreatic islets of malnourished mice.

scientific article published on August 2010

Liraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome.

scientific article published on 14 January 2014

Long-term dexamethasone treatment alters the histomorphology of acinar cells in rat parotid and submandibular glands

scientific article published on 03 September 2014

Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats

scientific article published on 10 January 2011

Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats.

scientific article

Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats

scientific article published on 08 November 2018

Prostate hyperplasia caused by long-term obesity is characterized by high deposition of extracellular matrix and increased content of MMP-9 and VEGF

scientific article published on 21 December 2014

Reduced glucose-induced insulin secretion in low-protein-fed rats is associated with altered pancreatic islets redox status.

scientific article

Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the beta-cell stimulus-secretion coupling.

scientific article published on 16 June 2010

Reduced pancreatic beta-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats.

scientific article published in October 2009

The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment.

scientific article published on 22 June 2010

The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice.

scientific article

Tissue integrity, costs and time associated with different agents for histological bone preparation.

scientific article published on 6 November 2016

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