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List of works by Marian Ludgate

A luminescent bioassay for thyroid blocking antibodies.

scientific article published on March 2001

A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer

scientific article published in June 2006

A novel thyrotropin receptor mutation in an infant with severe thyrotoxicosis

scientific article published on 01 October 1999

Adipogenesis in thyroid eye disease

scientific article published on 01 October 2000

Adipose thyrotrophin receptor expression is elevated in Graves' and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo

scientific article

Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy.

scientific article

Altered tear composition in smokers and patients with graves ophthalmopathy

scientific article

An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter

scientific article published on 01 July 2018

An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro

scientific article published on 01 August 1997

Analysis of T cell subsets in Graves' disease: alterations associated with carbimazole

scientific article

Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy (TAO)

scientific article published on August 1, 1997

Analysis of sequence and structure homologies between thyroglobulin and acetylcholinesterase: possible functional and clinical significance

scientific article published on 01 May 1986

Animal model of thyroid-associated orbitopathy.

scientific article

Animal models of Graves' disease

scientific article

Animal models of thyroid-associated ophthalmopathy

scientific article

Antibodies against 1D, a recombinant 64-kDa membrane protein, are associated with ophthalmopathy in patients with thyroid autoimmunity.

scientific article published on March 1994

Antibodies in the serum of patients with autoimmune thyroid disorders react with a recombinant 98 amino acid fragment of a full length 64 kDa eye muscle membrane protein which is also expressed in the thyroid

scientific article published on 01 January 1992

Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy

scientific article published on 01 December 1993

Antibodies to human thyroid peroxidase in autoimmune thyroid disease: studies with a cloned recombinant complementary deoxyribonucleic acid epitope

scientific article

Apoptosis in autoimmune and non-autoimmune thyroid disease

scientific article published on 01 June 1997

Association of FOXE1 polyalanine repeat region with papillary thyroid cancer

scientific article

Autoimmunity and thyroid growth: methods, concepts and misconceptions

scientific article published on 01 January 1987

Back to the Drawing Board for Antigens in Endocrine Ophthalmopathy?

scientific article published on January 1, 1993

Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein

scientific article published on December 1, 1992

Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context

scientific article published in September 2003

Biological activity of activating thyrotrophin receptor mutants: modulation by iodide.

scientific article published in February 2005

Biological effects of thyrotropin receptor activation on human orbital preadipocytes

scientific article

Brown fat and obesity: the next big thing?

scientific article published on June 2011

CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers

scientific article published on 01 July 2020

Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis

scientific article

Characterization of monoclonal antibodies to the human thyrotropin receptor

scientific article published on February 1, 1992

Cloning and sequencing of a novel 64-kDa autoantigen recognized by patients with autoimmune thyroid disease

scientific article

Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH

scientific article

Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies

scientific article

Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy.

scientific article

Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid.

scientific article

Complement component C9 in Graves' disease

scientific article published on 01 December 1986

Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.

scientific article published on August 1999

Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Behavior

scientific article published on 01 March 2020

Controlled Antenatal Thyroid Screening II: effect of treating maternal sub-optimal thyroid function on child cognition

scientific article published on 15 January 2018

Copy number variations and clinical outcome in atypical spitz tumors

scientific article published on 01 February 2011

Current evidence for and against the TSH receptor being the common antigen in Graves' disease and thyroid associated ophthalmopathy

scientific article published on June 1, 1995

Cyclosporin improves Graves' ophthalmopathy

scientific article published on 01 August 1983

Definition, at the molecular level, of a thyroglobulin-acetylcholinesterase shared epitope: study of its pathophysiological significance in patients with Graves' ophthalmopathy

scientific article

Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue.

scientific article

Demonstration of immunoglobulin G, A, and E autoantibodies to the human thyrotropin receptor using flow cytometry

scientific article published on 01 April 2002

Demonstration of reduced in vivo surface expression of activating mutant thyrotrophin receptors in thyroid sections.

scientific article published in February 2002

Demonstration of the existence of the alternatively spliced form of thyroid peroxidase in normal thyroid

scientific article published on 01 March 1991

Dermatoscopic vascular patterns in cutaneous Merkel cell carcinoma

scientific article published on 5 October 2011

Detection of antibodies blocking thyrotropin effect using Chinese hamster ovary cells transfected with the cloned human TSH receptor.

scientific article published on November 1994

Detection of thyroid-stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor.

scientific article published on February 1993

Development of a luminescent bioassay for thyroid stimulating antibodies

scientific article published on 01 January 1999

Development of an animal model of autoimmune thyroid eye disease

scientific article published on 01 April 1999

Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy

scientific article published on 30 November 2020

Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?

scientific article published on 15 October 2013

Early changes in thyroid-stimulating antibody activity following radioiodine therapy

scientific article published on October 2003

Effect of iodine on early stage thyroid autonomy.

scientific article published on 28 October 2010

Effect of lithium carbonate therapy on thyroid immune status in manic depressive patients: a prospective study

scientific article published on 01 September 1986

Effect of tri-iodothyronine on normal human lymphocyte function

scientific article published on 01 April 1984

Effects of contiguous scars in dermatoscopic evaluation of clinically atypical melanocytic nevi

scientific article published in May 2012

Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial

scientific article published on 24 March 2009

Effects of prostaglandin F(2α) on adipocyte biology relevant to graves' orbitopathy

scientific article

Evidence for thyrotropin receptor immunoreactivity in pretibial connective tissue from patients with thyroid-associated dermopathy

scientific article published in January 2002

Extrathyroidal thyroid hormone synthesis?

scientific article published on May 3, 2011

Failure to demonstrate cell-mediated immune responses to thyroid antigens in Graves' disease using in vitro assays of lymphokine-mediated migration inhibition

scientific article published on 01 January 1985

Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement

scientific article published on 10 September 2015

Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor

scientific article published on 01 February 1998

Gsalpha signalling suppresses PPARgamma2 generation and inhibits 3T3L1 adipogenesis

scientific article published on 21 May 2009

Gut Microbiome in BALB/c and C57BL/6J Mice Undergoing Experimental Thyroid Autoimmunity Associate with Differences in Immunological Responses and Thyroid Function

scientific article published on 14 August 2018

Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of disease.

scientific article

Homology between thyroglobulin and acetylcholinesterase: an explanation for pathogenesis of Graves' ophthalmopathy?

scientific article published on 01 July 1986

Identification of antigenic domains on the human sodium-iodide symporter which are recognized by autoantibodies from patients with autoimmune thyroid disease

scientific article published in June 2001

Identification of high molecular weight forms of inositol 1,4,5-trisphosphate 3-kinase in rat thymus and human lymphocytes

scientific article published in March 1994

Identification of the thyroid Na+/I- cotransporter as a potential autoantigen in thyroid autoimmune disease

scientific article published on 01 April 1995

Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R

scientific article published on 01 March 1994

Internet use and anxiety in people with melanoma and nonmelanoma skin cancer

scientific article published on 24 August 2011

Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years

scientific article published on 04 December 2018

Mapping thyroid peroxidase epitopes using recombinant protein fragments

scientific article published on 01 January 1995

Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.

scientific article

Meeting abstracts from the 64th British Thyroid Association Annual Meeting: Newcastle, UK. 13/05/2016.

scientific article published on 13 February 2017

Metabolic syndrome: is the preadipocyte to blame?

scientific article published on 01 January 2012

Metamorphic thyroid autoimmunity

scientific article published on 01 October 2008

Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial

scientific article published on 8 December 2009

Modulation of expression of somatostatin receptor subtypes in Graves' ophthalmopathy orbits: relevance to novel analogs.

scientific article published on 11 September 2007

Molecular genetics of the thyrotropin receptor.

scientific article published on January 1992

Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics

scientific article

Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia

scientific article

New insights into the pathogenesis and nonsurgical management of Graves orbitopathy

scientific article published on 30 December 2019

Novel TSHR germline mutation (Met463Val) masquerading as Graves' disease in a large Welsh kindred with hyperthyroidism

scientific article published on 01 December 2000

Overexpression of the extracellular domain of the thyrotrophin receptor in bacteria; production of thyrotrophin-binding inhibiting immunoglobulins

scientific article published on 01 August 1994

Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor.

scientific article published on January 1996

Pediatric melanoma: an opportunity for psychosocial research

scientific article published in May 2010

Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use?

scientific article

Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy.

scientific article published on 23 April 2014

Potent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development.

scientific article published on March 2004

Prevention and treatment of postpartum Graves' disease

scientific article published on October 1, 1997

Production and application of polyclonal antibody to human thyroid transcription factor 2 reveals thyroid transcription factor 2 protein expression in adult thyroid and hair follicles and prepubertal testis

scientific article

Prostaglandin F2-Alpha Eye Drops (Bimatoprost) in Graves' Orbitopathy: A Randomized Controlled Double-Masked Crossover Trial (BIMA Trial)

scientific article published on 01 April 2019

Quantification of cells expressing the thyrotropin receptor in extraocular muscles in thyroid associated orbitopathy

scientific article published on June 2005

Re: "An activating mutation of the thyrotropin receptor gene in hereditary non-autoimmune hyperthyroidism" by Yung-Seng Lee et al. J Pediatr Endocrinol Metab 2002; 15: 211-215

scientific article published on 01 November 2002

Recombinant TSH-receptor for determination of TSH-receptor-antibodies

scientific article published in January 1992

Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: a new animal model

scientific article published on 01 November 1994

Reevaluating thyrotropin receptor-induced mouse models of graves' disease and ophthalmopathy.

scientific article published on 11 November 2004

Regulation and tissue distribution of the human sodium iodide symporter gene

scientific article published on 01 October 1998

Role of Hyaluronan in Human Adipogenesis: Evidence from in-Vitro and in-Vivo Studies

scientific article published on 31 May 2019

Shining a light on thyroid eye disease

scientific article published on 28 February 2020

Stimulation of autologous blood lymphocytes by malignant lymphoma cells and homogenates

scientific article published on December 1, 1976

T-cell subset analysis of cryopreserved human peripheral blood mononuclear cells

scientific article published on 01 January 1983

TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).

scientific article published on 4 April 2017

TSH receptor activation and body composition

scientific article published on 16 September 2009

The Modulation of the Human Sodium Iodide Symporter Activity by Graves’ Disease Sera1

scientific article published on April 1, 1998

The Molecular Genetics of Three Thyroid Autoantigens: Thyroglobulin, Thyroid Peroxidase and the Thyrotropin Receptor

scientific article published on January 1, 1990

The Role of Thyrotropin Receptor Activation in Adipogenesis and Modulation of Fat Phenotype

scientific article

The Search for Biomarkers of Disease: Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, Tears, and Thyroid-Associated Ophthalmopathy

scientific article published on October 1, 2012

The W546X mutation of the thyrotropin receptor gene: potential major contributor to thyroid dysfunction in a Caucasian population

scientific article published on 01 March 2003

The microbiota and autoimmunity: Their role in thyroid autoimmune diseases.

scientific article

The prevalence and progression of autoimmune thyroid disease in the elderly

scientific article published on 01 June 1984

The prevalence of anti-acetylcholinesterase antibodies in autoimmune disease

scientific article published on 01 December 2004

The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol

scientific article

The sodium iodide symporter gene and its regulation by cytokines found in autoimmunity.

scientific article published on September 1998

The sodium iodide symporter is unlikely to be a thyroid/breast shared antigen.

scientific article published on 8 August 2015

The thyrotropin receptor as a model to illustrate receptor and receptor antibody diseases

scientific article published on January 1995

The thyrotropin receptor in thyroid diseases.

scientific article published on December 1997

The thyrotropin receptor in thyroid eye disease.

scientific article

Thyroid stimulating immunoglobulins, like thyrotropin activate both the cyclic AMP and the PIP2 cascades in CHO cells expressing the TSH receptor.

scientific article published on October 1992

Thyroid transcription factor-2 gene expression in benign and malignant thyroid lesions.

scientific article

Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules.

scientific article

Thyroperoxidase, but not the thyrotropin receptor, contains sequential epitopes recognized by autoantibodies in recombinant peptides expressed in the pUEX vector

scientific article

Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.

scientific article

Thyrotropin receptor transcripts in human adipose tissue

scientific article published on 01 June 1997

Tissue specificity and serologic reactivity of an autoantigen associated with autoimmune thyroid disease

scientific article published on 01 August 1993

Towards an antigenic map of human thyroglobulin: identification of ten epitope-bearing sequences within the primary structure of thyroglobulin

scientific article

Transcription of thyroid autoantigens in non-expressing tissues.

scientific article published on January 1998

Transfer of thyroiditis, with syngeneic spleen cells sensitized with the human thyrotropin receptor, to naive BALB/c and NOD mice

scientific article published in November 1996

Transient congenital hypothyroidism due to thyroid-stimulating hormone receptor blocking antibodies: a case series

scientific article published on 23 May 2011

Two novel mutations in the thyrotropin (TSH) receptor gene in a child with resistance to TSH.

scientific article published in April 1997

Unlike thyrotropin, thyroid-stimulating antibodies do not activate phospholipase C in human thyroid slices

scientific article

Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease

scientific article

W546X mutation of the thyrotropin receptor causes subclinical hypothyroidism in various clinical settings

scientific article published on 24 May 2007

Western blot analysis of thyrotropin receptor expression in human thyroid tumours and correlation with TSH-binding

scientific article published on 01 November 1994

[Basedow disease following metastatic thyroid cancer]

scientific article published on 01 April 1996