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List of works by Kian Fan Chung

"Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999.

scientific article

"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

scientific article published on 03 January 2019

A Topological Data Analysis Network Model of Asthma Based on Blood Gene Expression Profiles

article

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

scientific article published on 15 February 2017

A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma

scientific article published on 01 November 1997

A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model

scientific article published on 01 March 2014

A computational framework for complex disease stratification from multiple large-scale datasets.

scientific article published on 29 May 2018

A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice

scientific article

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

scientific article

A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.

scientific article published on 9 April 2010

Activation of NF-kappaB transcription factor in asthma death

scientific article published in March 2009

Acute and chronic cough

scientific article published on 01 January 2004

Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma

scientific article published in July 2004

Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity

scientific article published on 01 November 2019

Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough?

scientific article

Airway inflammation despite loss of bronchial hyper-responsiveness after multiple ozone exposures

scientific article published in January 1997

Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma

scientific article

Airway neuropeptides and neutral endopeptidase in asthma

scientific article published on 01 May 1996

Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma

scientific article published on January 2014

Alterations of the arginine metabolome in asthma

scientific article

American College of Chest Physicians' cough guidelines

scientific article published in March 2006

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

scientific article

An integrative systems biology approach to understanding pulmonary diseases

scientific article published in June 2010

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases

scientific article published on 08 February 2013

Assessment and measurement of cough: the value of new tools.

scientific article

Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma

scientific article published on 07 January 2021

Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD.

scientific article published on 23 August 2009

AsthmaMap: An expert-driven computational representation of disease mechanisms

scholarly article by Alexander Mazein et al published 30 July 2018 in Clinical & Experimental Allergy

Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma

scientific article published in March 2002

Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Inhibitor SP600125

scientific article published on 25 April 2007

BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle

scientific article published on 19 February 2015

Bacteria in sputum of stable severe asthma and increased airway wall thickness ⬇️

scientific article published on April 18, 2012

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

scientific article published on 24 September 2007

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma

scientific article published on 10 September 2019

Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy

scientific article

Bradykinin-induced airway microvascular leakage is potentiated by captopril and phosphoramidon

scientific article published in August 1991

Bradykinin–evoked sensitization of airway sensory nerves: A mechanism for ACE–inhibitor cough

scientific article published on 01 July 1996

Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression

scientific article

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression.

scientific article

COUGH: consolidating a mature field for the next 5 years ⬇️

scientific article published on April 10, 2011

Capsaicin cough sensitivity in bronchiectasis.

scientific article

Capsaicin cough sensitivity in smokers with and without airflow obstruction

scientific article published on 10 January 2009

Cardio- and cerebrovascular safety of indacaterol vs formoterol, salmeterol, tiotropium and placebo in COPD.

scientific article published on 11 January 2011

Ceramide Induction of COX-2 and PGE2 in Pulmonary A549 Cells Does Not Involve Activation of NF-κB

article

Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients

scientific article published on 01 February 1996

Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program

scientific article

Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program

scientific article

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

scientific article

Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease.

scientific article

Chromosome 17q21 SNP and severe asthma.

scientific article

Chronic cough as a neuropathic disorder.

scientific article published on 03 May 2013

Chronic ‘cough hypersensitivity syndrome’: A more precise label for chronic cough

scientific article published on 01 February 2011

Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function

scientific article

Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma

scientific article

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

scientific article published on 10 September 2015

Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort

scientific article published on 01 April 2022

Clinical cough VI: the need for new therapies for cough: disease-specific and symptom-related antitussives.

scientific article published on January 2009

Clinical phenotypes of asthma should link up with disease mechanisms

scientific article

Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma.

scientific article

Comparing biologicals and small molecule drug therapies for chronic respiratory diseases

scientific article published on 08 January 2019

Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice.

scientific article published on October 2000

Complete inhibition of allergic airway inflammation and remodelling in quadruple IL-4/5/9/13-/- mice.

scientific article published in October 2007

Compliance with an oral asthma medication: a pilot study using an electronic monitoring device

scientific article published on 01 September 2000

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET

scientific article published on 11 February 2019

Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma

scientific article published on 05 May 2005

Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology.

scientific article published on 18 February 2010

Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma

scientific article published on September 2012

Corticosteroid modulation of immunoglobulin expression and B-cell function in COPD.

scientific article published on 17 February 2016

Corticosteroid therapy in asthma: are metabolic considerations important?

scientific article published in January 1992

Cough

scientific article published on 14 December 2006

Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity

scientific article published in January 2006

Cough as a symptom.

scientific article

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder.

scientific article

Currently available cough suppressants for chronic cough.

scientific article

Cutaneous allergic response in atopic dogs: relationship of cellular and histamine responses.

scientific article published on February 1988

Cutaneous mast cell heterogeneity: response to antigen in atopic dogs

scientific article published in November 1986

Cys34 adductomes differ between patients with chronic lung or heart disease and healthy controls in central London

journal article published in 2018

Cytokine inhibition in the treatment of COPD.

scientific article

Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease

scientific article published in June 2001

Defining phenotypes in asthma: a step towards personalized medicine

scientific article published on May 2014

Delivering effective asthma care - how do we implement asthma guidelines?

scientific article published on 01 February 2000

Detection of bronchiectasis by high-resolution computed tomography in the yellow nail syndrome

scientific article published on 01 June 1991

Determinants of exhaled breath condensate pH in a large population with asthma

scientific article

Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity ⬇️

scientific article published on May 4, 2011

Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI) ⬇️

scientific article published on November 23, 2010

Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages

scientific article published in May 2004

Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells

scientific article published on April 2008

Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: Relationship to bronchial hyperresponsiveness

article

Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung.

scientific article published in January 2002

Distribution of respiratory mucin proteins in human nasal mucosa

scientific article published in March 2003

Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control

scientific article

Dose-dependent inhibition of allergic inflammation and bronchial hyperresponsiveness by budesonide in ovalbumin-sensitised Brown-Norway rats

scientific article published on 25 January 2007

Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations.

scientific article published on July 2004

EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD

scientific article published on 01 May 2011

ERS guidelines on the assessment of cough

scientific article published on 01 June 2007

Effect of 5-HT1A receptor agonist, 8-OH-DPAT, on cough responses in the conscious guinea pig

scientific article published on 01 August 1997

Effect of CD8+ T-cell depletion on bronchial hyper-responsiveness and inflammation in sensitized and allergen-exposed Brown-Norway rats

scientific article published on 01 March 1999

Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

scientific article published in January 1993

Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.

scientific article

Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects

scientific article published on 01 August 1988

Effect of a bradykinin receptor antagonist, HOE 140, against bradykinin- and vagal stimulation-induced airway responses in the guinea-pig

scientific article published in January 1994

Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man

scientific article published on 01 January 1987

Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma

scientific article

Effect of a topical corticosteroid on airway hyperresponsiveness and eosinophilic inflammation induced by trimellitic anhydride exposure in sensitized guinea pigs

scientific article

Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma

scientific article published on November 1994

Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages

scientific article published in February 2003

Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats

scientific article

Effect of beta 2-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

scientific article published in September 1993

Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.

scientific article published on 27 June 2008

Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages

scientific article published in June 2004

Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man

scientific article published on 01 September 1988

Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats

scientific article

Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects

scientific article published on 01 January 1992

Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma

scientific article published on 19 October 2009

Effect of serum on diesel exhaust particles (DEP)-induced apoptosis of airway epithelial cells in vitro.

scientific article published on 20 February 2013

Effect of silver nanospheres and nanowires on human airway smooth muscle cells: role of sulfidation

scientific article published on 09 October 2020

Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.

scientific article

Effect of topical capsaicin on the cutaneous responses to inflammatory mediators and to antigen in man.

scientific article

Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats

scientific article published in February 2002

Effective antitussives for the cough patient: an unmet need.

scientific article published on 6 November 2006

Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study

scientific article published on 26 July 2008

Effects of Cigarette Smoke on Pulmonary Homeostasis

scientific article published on 01 February 2005

Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model.

scientific article

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

scientific article published in December 2000

Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features.

scientific article published in May 2005

Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats

scientific article

Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma

scientific article published on 01 September 1999

Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays.

scientific article published in August 2004

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma

scientific article

Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma

scientific article published in April 2004

Efficacy of a cell phone-based exercise programme for COPD.

scientific article

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

scientific article published on 27 June 2019

Exploring the clinical relevance of cough hypersensitivity syndrome

scientific article published on 15 January 2020

Expression and activity of histone deacetylases in human asthmatic airways

scientific article published in August 2002

Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies

scientific article published on 01 September 2001

Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung

scientific article published in February 2002

Expression of respiratory mucins in fatal status asthmaticus and mild asthma

scientific article published in April 2002

Expression of transforming growth factor-beta (TGF-beta) in chronic idiopathic cough

scientific article

Failure of sputum eosinophilia after eotaxin inhalation in asthma.

scientific article published on May 2004

Fluticasone furoate and vilanterol for the treatment of chronic obstructive pulmonary disease

scientific article

Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma

scientific article published in May 2002

Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle

scientific article published on 10 July 2007

Formoterol protects against platelet-activating factor-induced effects in asthma

scientific article

From the authors

Fundamentals of pulmonary drug delivery.

scientific article

Future Risks in Patients With Severe Asthma

scientific article published on 01 November 2019

GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases

scientific article published on 14 April 2006

Gabapentin: a suppressant for refractory chronic cough ⬇️

scientific article published on August 28, 2012

Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study

scientific article published on 01 September 1999

Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB.

scientific article published on 29 January 2008

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

scientific article

Green respiratory health care: Time for us all to act

scientific article published on 06 March 2018

H+/K+-ATPase (proton pump) inhibitors dampen increased cough reflex: more than gastric acid suppression

scientific article published in March 2005

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

scientific article published on 13 January 2020

Haze, health and disease

scientific article

High-resolution analytical electron microscopy reveals cell culture media-induced changes to the chemistry of silver nanowires

scientific article

How to diagnose and phenotype asthma.

scientific article published on 07 July 2012

How variability in clinical phenotypes should guide research into disease mechanisms in asthma

scientific article (publication date: December 2013)

Hydrogen sulfide as a potential biomarker of asthma

scientific article

IFN-γ: A Driver of Cough Hypersensitivity Pathways in Chronic Cough?

scientific article published on 01 October 2018

IL-17-high asthma with features of a psoriasis immunophenotype

scientific article published on 15 April 2019

IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema

scientific article

IL-22 suppresses IFN-γ-mediated lung inflammation in asthmatic patients

scientific article published on 19 November 2012

IL-5 in asthma.

scientific article published in August 2002

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma

scientific article published on 06 December 2018

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

scientific article

Immune modulation via T regulatory cell enhancement: disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases - An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)

scientific article published on 27 June 2020

Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy

scientific article published on 28 July 2011

Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD

scientific article published on 13 February 2014

Impacts of a nanosized ceria additive on diesel engine emissions of particulate and gaseous pollutants

scientific article

Impaired macrophage phagocytosis of bacteria in severe asthma.

scientific article

Importance of hedgehog interacting protein and other lung function genes in asthma

scientific article

Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness.

scientific article published on 23 June 2006

Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats

scientific article

Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma

scientific article published in February 2005

Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.

scientific article published on 9 February 2012

Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages

scientific article

Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.

scientific article published in September 2002

Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough

scientific article published on 24 September 2004

Increased p21CIP1/WAF1and B Cell Lymphoma Leukemia-xLExpression and Reduced Apoptosis in Alveolar Macrophages from Smokers

scientific article published on 01 September 2002

Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma.

scientific article published on 6 December 2014

Indacaterol: pharmacologic profile, efficacy and safety in the treatment of adults with COPD.

scientific article published on February 2011

Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung

scientific article

Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase

scientific article published on 14 January 2005

Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma.

scientific article published on 20 July 2009

Inflammatory biomarkers in severe asthma

scientific article published on January 2012

Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.

scientific article published on 26 June 2009

Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage

scientific article published in January 1991

Inhaled frusemide and exercise-induced bronchoconstriction in children with asthma

scientific article

Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in brown-Norway rats

scientific article published on 01 February 1995

Inhibition of chemokine production from human airway smooth muscle cells by fluticasone, budesonide and beclomethasone

scientific article

Inhibition of ozone-induced lung neutrophilia and nuclear factor-κB binding activity by vitamin A in rat

scientific article

Inhibition of the cutaneous response to antigen by a thromboxane-synthetase inhibitor (OKY-046) in allergic dogs

scientific article published in August 1989

Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway rats

scientific article published on 01 October 1999

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.

scientific article

Instability of sputum molecular phenotypes in U-BIOPRED severe asthma

scientific article published on 02 October 2020

Integrated care pathways for airway diseases (AIRWAYS-ICPs).

scientific article published on 12 June 2014

Inter-disease comparison of research quantity and quality: bronchial asthma and chronic obstructive pulmonary disease

scientific article published in March 2009

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

scientific article published on 12 December 2013

International research collaboration: The way forward

scientific article published on 17 May 2018

Intrinsic differences of the airway epithelium in childhood allergic asthma

scientific article published on 01 November 2006

Involvement of haemoxygenase-1 in ozone-induced airway inflammation and hyperresponsiveness

scientific article published on 01 July 2000

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

scientific article published in 2023

John Widdicombe’s contribution to respiratory physiology and cough: reminiscences ⬇️

scientific article published on March 6, 2013

Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man.

scientific article

Kinase inhibitors and airway inflammation.

scientific article

Label-Free Time-of-Flight Secondary Ion Mass Spectrometry Imaging of Sulfur-Producing Enzymes inside Microglia Cells following Exposure to Silver Nanowires

scientific article published on 14 August 2019

Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

scientific article published in March 1996

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome

scientific article published on 8 May 2018

Leukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy.

scientific article published on July 1995

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers

scientific article published on 17 September 2018

Lipid-laden bronchoalveolar macrophages in asthma and chronic cough

scientific article published on 10 October 2013

Loop diuretics and asthma

scientific article published on January 1, 1992

Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages

scientific article published in November 2001

Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation

scientific article

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

scientific article published in September 2009

Management of chronic cough

scientific article

Managing severe asthma in adults: lessons from the ERS/ATS guidelines

scientific article

Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids.

scientific article published in November 2002

Maximal airway plateau responses and eosinophils in cough variant asthma

scientific article published on 01 October 2004

Measurement of cough.

scientific article

Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD).

scientific article

Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta

scientific article

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

scientific article

Methods of assessing cough and antitussives in man.

scientific article published on October 1996

MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy

scientific article

Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness

scientific article published on 27 June 2019

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages

scientific article published on 18 July 2003

Modeling Population Exposures to Silver Nanoparticles Present in Consumer Products

scientific article

Modeling in vitro cellular responses to silver nanoparticles

scientific article

Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619

scientific article published on 01 November 1985

Modulation of neurally mediated airway microvascular leakage in guinea-pig airways by beta 2-adrenoceptor agonists

scientific article published in May 1992

Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13.

scientific article published on 16 April 2008

Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease.

scientific article published on August 2010

Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport.

scientific article published in March 2004

Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease

scientific article published in November 2004

Mucus and fatal asthma

scientific article published in January 2004

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.

scientific article published on June 2008

Murine models of asthma.

scientific article

Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

scientific article published on 04 August 2016

Nature of airway inflammation and remodeling in chronic cough

scientific article

Neurogenic goblet cell secretion and bronchoconstriction in guinea pigs sensitised to trimellitic anhydride

scientific article published in January 1995

Neuropeptide Y (NPY).

scientific article published in January 2004

Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression

scientific article published on 01 August 2003

Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway

scientific article (publication date: October 2006)

New immunological approaches and cytokine targets in asthma and allergy.

scientific article

New treatments for severe treatment-resistant asthma: targeting the right patient

scientific article published on 09 August 2013

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease

scientific article published on 28 September 2005

Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations.

scientific article published on April 2003

Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI.

scientific article published in February 2013

Outdoor air pollution and respiratory health in Asia

scientific article published in October 2011

Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches.

scientific article published on May 2010

Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease

scientific article

Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

scientific article

Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease.

scientific article published on 14 December 2009

Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids.

scientific article published on February 1996

Parameters associated with persistent airflow obstruction in chronic severe asthma

scientific article published in July 2004

Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques.

scientific article

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

scientific article published on 01 August 2020

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

scientific article

Peripheral airways obstruction on high-resolution computed tomography in chronic severe asthma

scientific article published on 01 March 1998

Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS

scientific article

Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle.

scientific article

Pharmacology of airway inflammation in asthma.

scientific article published on January 1990

Pharmacology of corticosteroids.

scientific article

Pharmacotherapeutic Options for Chronic Refractory Cough

scientific article published on 17 April 2020

Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.

scientific article published on 05 January 2010

Phospho-p38 MAPK expression in COPD patients and asthmatics and in challenged bronchial epithelium

scientific article

Physician-prescribed Asthma Treatment Regimen does not differ Between Smoking and Non-smoking Patients With Asthma in Seoul and Gyunggi province of Korea

scientific article

Postnasal drip and chronic cough: An open interventional study.

scientific article published on 29 May 2009

Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125.

scientific article published on 15 December 2004

Precision medicine for the discovery of treatable mechanisms in severe asthma

scientific article published on 15 April 2019

Predicting Response to Triamcinolone in Severe Asthma by Machine Learning. Solving the Enigma.

scientific article

Predicting and evaluating response to omalizumab in patients with severe allergic asthma

scientific article published in July 2007

Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines

scientific article

Prevalence, pathogenesis, and causes of chronic cough

scientific article

Pro-oxidant iron in exhaled breath condensate: a potential excretory mechanism

scientific article published on 21 April 2011

Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung

scientific article published in March 1996

Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD

scientific article published on 24 February 2014

Prostaglandin F2α increases responsiveness of pulmonary airways in dogs

scientific article published in October 1984

Protease-activated receptor 2 in regulation of bronchomotor tone: effect of tobacco smoking.

scientific article

Protease-activated receptors in human airways: Upregulation of PAR-2 in respiratory epithelium from patients with asthma ⬇️

scientific article published on November 1, 2001

Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

scientific article published on 4 August 2017

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats

scientific article

RAGE: a new frontier in chronic airways disease

scientific article

RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol

scientific article published in December 2001

Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program

scientific article

Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma

scientific article published in July 1990

Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cells

scientific article published on 17 September 2004

Regulation of human lung epithelial cell numbers by diesel exhaust particles.

scientific article published on 2 February 2006

Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.

scientific article

Regulation of protease-activated receptor-1 in mononuclear cells by neutrophil proteases.

scientific article published in March 2003

Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma

scientific article published on March 2000

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

scientific article published on 20 May 2008

Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling

scientific article published on 01 September 1999

Repeated allergen inhalation induces cytoskeletal remodeling in smooth muscle from rat bronchioles.

scientific article published in February 2007

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

scientific article (publication date: February 2016)

Resolution of allergic airways inflammation but persistence of airway smooth muscle proliferation after repeated allergen exposures.

scientific article published in February 2004

Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma

scientific article (publication date: 2012)

Road ahead to respiratory health: experts chart future research directions.

scientific article published on 11 March 2009

Role for platelet-activating factor in asthma ⬇️

scientific article published on December 1, 1991

Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia

scientific article published on 12 July 2007

Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells

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Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation

scientific article published on 14 November 2008

Role of inflammation in the hyperreactivity of the airways in asthma

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Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury

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Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness

scientific article published in September 2002

Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation.

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Role of non-coding RNAs in maintaining primary airway smooth muscle cells

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Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.

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Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs

scientific article published in July 1993

STAT4 activation in smokers and patients with chronic obstructive pulmonary disease

scientific article published in July 2004

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.

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Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma

scientific article published on 27 September 2007

Safety of bronchial thermoplasty in patients with severe refractory asthma

scientific article published on 13 June 2013

Safety of investigative bronchoscopy in the Severe Asthma Research Program

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Salmeterol/fluticasone combination in the treatment of COPD.

scientific article published on January 2006

Semantics and types of cough

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Severe acute respiratory syndrome: global initiatives for disease diagnosis.

scientific article published on November 2003

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

scientific article published on 6 October 2016

Severe asthma: definition and mechanisms.

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Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

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Signalling and transcriptional regulation in inflammatory and immune cells: importance in lung biology and disease

scientific article published on 01 November 2005

Sleep quality and asthma control and quality of life in non-severe and severe asthma

scientific article published on 20 November 2011

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

scientific article published on 07 January 2021

Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma

scientific article published on 10 November 2012

Sputum macrophage diversity and activation in asthma: role of severity and inflammatory phenotype

scientific article published on 01 August 2020

Sputum microbiota in severe asthma patients: Relationship to eosinophilic inflammation

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Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

scientific article published on 12 April 2018

Sputum-to-serum hydrogen sulfide ratio in COPD.

scientific article published on 17 July 2014

Steroid resistance in asthma: mechanisms and treatment options

scientific article published on April 2008

Stratification of asthma phenotypes by airway proteomic signatures

scientific article published on 28 March 2019

Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism

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Suppression of prolonged fever during treatment of pulmonary tuberculosis: importance of using twice versus single daily dose of prednisolone.

scientific article published on June 1983

Systematic assessment of difficult-to-treat asthma

scientific article published in September 2003

Systems medicine and integrated care to combat chronic noncommunicable diseases

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T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.

scientific article published in August 2009

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED.

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TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD.

scientific article published on 28 December 2017

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.

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Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease

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Targeted omics and systems medicine: personalising care

scientific article published on 16 September 2014

The 2008 Fifth International Cough Symposium: mechanisms and treatment

scientific article published on 30 October 2008

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.

scientific article published on 11 January 2016

The Seventh International Symposium on Cough: hypertussivity and allotussivity

scientific article published on 17 July 2013

The Sixth 2010 London International Symposium on Cough: A translational approach

scientific article published on 26 January 2011

The airway smooth muscle cell: a major contributor to asthma?

scientific article published on 01 March 2000

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts

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The effect of anion transport inhibitors and extracellular Cl- concentration on eosinophil respiratory burst activity

scientific article published on 01 June 1992

The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs

scientific article published in January 1996

The investigation of severe asthma to define phenotypes.

scientific article published on May 2012

The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease.

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The small airway epithelium as a target for the adverse pulmonary effects of silver nanoparticle inhalation

scientific article published on 11 May 2018

The stability of silver nanoparticles in a model of pulmonary surfactant

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Tobacco industry lobbyists and their health-care clients

scientific article published in The Lancet

Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle

scientific article published on 03 July 2006

Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease

scientific article published in January 2005

Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma

scientific article

Treatable Traits in the European U-BIOPRED Adult Asthma Cohorts

scientific article published on 12 November 2018

Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics

scientific article published on 31 August 2020

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

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Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.

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Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

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Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

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Update on glucocorticoid action and resistance

scientific article published on 01 March 2006

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation

scientific article published on 15 July 2020

Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma

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Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells

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Volatile Organic Compounds Breathprinting of U-BIOPRED Severe Asthma smokers/ex-smokers cohort

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XXIV World Allergy Congress 2015

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p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma

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p38 mitogen-activated protein kinase pathways in asthma and COPD.

scientific article published on June 2011

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