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List of works by Thomas Mandrup-Poulsen

(19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

scientific article

35th Annual Meeting of the European Association for the Study of Diabetes

article

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats

scientific article

A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

scientific article published on 7 June 2016

A genetic marker for atherosclerosis?

scientific article published on 01 May 1984

A guiding map for inflammation

scientific article published on July 2017

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

scientific article published on 01 January 1986

Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

scientific article

Altering β-cell number through stable alteration of miR-21 and miR-34a expression

scientific article

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

scientific article published on 7 December 2015

An immune origin of type 2 diabetes?

scientific article

Anti-cytokine therapies in T1D: Concepts and strategies

scientific article published on 14 February 2013

Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist

scientific article (publication date: 3 February 2014)

Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

scientific article

Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway

scientific article published on 21 June 2011

Apoptosis and the pathogenesis of IDDM: a question of life and death ⬇️

scientific article published on 01 October 1998

Apoptotic signal transduction pathways in diabetes ⬇️

scientific article published on October 15, 2003

Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

scientific article published in May 2003

Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance

article

BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children

scientific article published on 6 November 2014

Beta cell death and protection

scientific article published on November 2003

Blockade of interleukin 1 in type 1 diabetes mellitus

scientific article published on March 2010

Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells

scientific article

Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.

scientific article published on 24 September 2003

Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

scientific article

Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase ⬇️

scientific article published on October 1, 1998

Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury

scientific article published on 01 January 1995

Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia

scientific article published on 16 June 2020

Complete mutation scan of the human Fas ligand gene: Linkage studies in Type I diabetes mellitus families

article

Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families

scientific article published on 01 January 2002

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

scientific article published on 23 March 2006

Cytokines and Pancreatic β-Cell Apoptosis

scientific article published on 20 April 2016

Cytokines and beta-cell biology: from concept to clinical translation

scientific article

Cytokines and type 1 diabetes: a numbers game

scientific article published on March 2011

Cytokines cause functional and structural damage to isolated islets of Langerhans

scientific article published on 01 August 1985

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

scientific article

DNA sequences flanking the insulin gene on chromosome 11 confer risk of atherosclerosis

scientific article

Deficiency of erythropoietin is not responsible for the anaemia associated with cyclosporin treatment of insulin-dependent diabetes mellitus. Canadian-European Randomized Control Trial Group

scientific article published on 01 June 1993

Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production

scientific article published on 01 August 1997

Diabetes

scientific article published on 01 April 1998

Diabetes and suppressors of cytokine signaling proteins

scientific article published on February 2007

Diabetes mellitus, atherosclerosis, and the 5' flanking polymorphism of the human insulin gene

scientific article published in January 1986

Dietary Supplementation with co-3-Polyunsaturated Fatty Acids Decreases Mononuclear Cell Proliferation and Interleukin-1beta Content but not Monokine Secretion in Healthy and Insulin-Dependent Diabetic Individuals

scientific article published on 01 October 1991

Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats

scientific article published on 01 August 1993

Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

scientific article

Disappearance and reappearance of islet cell cytoplasmic antibodies in cyclosporin-treated insulin-dependent diabetics

scientific article published in March 1985

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

article

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

scientific article

Elevated transferrin saturation and risk of diabetes: three population-based studies

scientific article

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

scientific article published on 22 January 2019

Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

scientific article published on 21 January 2011

Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells

scientific article published on 29 October 2020

Erratum: IL-1 family nomenclature

scholarly article by Charles A. Dinarello et al published March 2011 in Nature Immunology

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

scientific article published on 11 November 2005

Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 dia

scientific article published on 15 March 2013

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

scientific article published in March 2009

Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas

scientific article published on 01 January 1990

Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.

scientific article

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

scientific journal article

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

scientific article published in July 2004

Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression

scientific article published on 01 September 2000

Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No.

scientific article

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

scientific article published on 10 March 2006

HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent

scientific article

Helsinki alert of biodiversity and health

scientific article published on 23 April 2015

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

scientific article

Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

scientific article published on 25 January 2011

Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats

scientific article published on 26 May 2015

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

scientific journal article

IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin

scientific article published in July 2002

IAPP boosts islet macrophage IL-1 in type 2 diabetes

scientific article published on 01 October 2010

IL-1 family nomenclature

scientific article

IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes

scientific article published in June 2009

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

scientific article

IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

scientific article published on 23 May 2006

IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

article

Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity

scientific article published in June 2004

Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients

scientific article

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice

scientific article

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

scientific article

Inhibition of beta cell growth and function by bone morphogenetic proteins

scientific article

Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

scientific article published on 31 January 2007

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

scientific article

Insulin autoantibodies are associated with islet cell antibodies; their relation to insulin antibodies and B-cell function in diabetic children

scientific article published in September 1988

Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review

scientific article

Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism

scientific article published on 01 February 2000

Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.

scientific article published on September 1994

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

scientific article

Interleukin-1 Antagonists and Other Cytokine Blockade Strategies for Type 1 Diabetes ⬇️

scientific article published on December 28, 2012

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials ⬇️

scientific article published on 05 April 2013

Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

scientific article published on 22 December 2015

Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?

scientific article published on 01 June 2014

Interleukin-1 antagonists for diabetes

scientific article published on 26 May 2013

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

scientific article (publication date: 12 April 2007)

Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

scientific article published in June 1998

Interleukin-6 and diabetes: the good, the bad, or the indifferent?

scientific article

Intra-Peritoneal Administration of Interleukin-1β Induces Impaired Insulin Release from the Perfused Rat Pancreas

scientific article published on 01 January 1990

Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

scientific article published on 4 May 2016

Iron Status and Gestational Diabetes-A Meta-Analysis.

scientific article

Iron: the hard player in diabetes pathophysiology.

scientific article published on April 2014

Islet cell cytoplasmic antibodies (ICA) in diabetes and disorders of glucose tolerance

scientific article

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression

scientific article

JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

scientific journal article

Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus

scientific article published in February 2000

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

article published in the Proceedings of the National Academy of Sciences of the United States of America

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

scientific article published on 28 September 2010

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

scientific article

Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans

scientific article published on 01 May 1986

MicroRNAs as regulators of beta-cell function and dysfunction

scientific article published on 29 September 2015

Monocyte Function in IDDM Patients and Healthy Individuals

scientific article published on 01 September 1990

Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes.

scientific article published on 6 July 2010

Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene

scientific article

Need for reclassification of diabetes secondary to iron overload in the ADA and WHO classifications

scientific article published on 01 June 2014

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

scientific article published on 25 August 2005

Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

scientific article published on 14 October 2014

Perspective: Testing failures

journal article; published in Nature on 2012-05-16

Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action

scientific article published on 23 December 2005

Poor pregnancy outcome in women with type 2 diabetes

scientific article published in February 2005

Prevalence of hereditary haemochromatosis in late-onset type 1 diabetes mellitus: a retrospective study

scientific article published on 01 October 2001

Process measures and outcome research as tools for future improvement of diabetes treatment quality

scientific article published on June 2002

Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity

scientific article published on 23 December 2020

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

scientific article published on 26 May 2009

Proliferation of sorted human and rat beta cells

scientific article published on 10 November 2007

RELATION BETWEEN BREAST-FEEDING AND INCIDENCE RATES OF INSULIN-DEPENDENT DIABETES MELLITUS

scientific article published in November 1984

RNA modifications by oxidation: a novel disease mechanism?

scientific article published on 28 January 2012

RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines

scientific article published on 14 July 2006

Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?

scientific article published on 01 January 1991

Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats

scientific article published in April 1992

Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256–2258.

scientific article published on 11 May 2012

Role of IL-1beta in type 2 diabetes

scientific article published on August 2010

Serum Proteome Pool Changes in Type 2 Diabetic Patients Treated with Anakinra

Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

scientific article published in February 2013

Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis

scientific article published on 28 July 2015

Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

scientific article published on 27 March 2014

Small-molecule inhibition of inflammatory β-cell death

scientific article

Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

scientific article published on 16 March 2006

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

scientific article

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

scientific article

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

scientific article published on 22 July 2008

Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

scientific article

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

scientific article published on 19 June 2009

Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

scientific article published on 31 October 2011

TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans

scientific article published on 01 November 2000

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

scientific article published on 20 November 2015

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

scientific article published on 17 June 2020

The Fas pathway is involved in pancreatic beta cell secretory function

scholarly article

The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines

scientific article published in October 2003

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

scientific article published on 28 July 2019

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

scientific article published on 31 July 2018

The anti-interleukin-1 in type 1 diabetes action trial--background and rationale

scientific article published on May 2009

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

scientific article

The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

scientific article published on April 2008

The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

scientific article published on 24 April 2017

The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes

scientific article published on 01 November 2000

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

scientific article published on 13 February 2020

The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

scientific article published in November 2012

The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro

scientific article

The role of growth hormone and glucocorticoid in glucose handling in vivo

scientific article published on 01 July 1999

The role of interleukin-1 in the pathogenesis of IDDM.

scientific article published on September 1996

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

scientific article published on 04 March 2008

TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC.

scientific article

Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice

scientific article published on 13 July 2015

Total and cause-specific mortality by elevated transferrin saturation and hemochromatosis genotype in individuals with diabetes: two general population studies

scientific article published on 15 October 2013

Total mortality by elevated transferrin saturation in patients with diabetes

scientific article published on 25 June 2013

Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis

scientific article published on 09 October 2012

Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

scientific article published on 25 April 2019

Type 2 diabetes mellitus: a metabolic autoinflammatory disease

scientific article published on 25 May 2013

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.

scientific article published on 11 January 2005

What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus?

scientific article published on 01 May 1993

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