List of works - Helder Maiato

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition.

scientific article published in November 2016

A chromosome separation checkpoint: A midzone Aurora B gradient mediates a chromosome separation checkpoint that regulates the anaphase-telophase transition.

scientific article

A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis

scientific article

An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region

scientific article

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network

scientific article

Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis

scientific article

Aurora Mitochondrialis drives fission during mitosis

scientific article published in September 2011

CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity ⬇️

scientific article published on September 17, 2010

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

scientific article published on 5 February 2012

Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments

scientific article

Cell Division: NuMA Bears the Load in the Spindle.

scientific article published in August 2017

Chromator is required for proper microtubule spindle formation and mitosis in Drosophila

scientific article published on 24 July 2009

Closing the tubulin detyrosination cycle.

scientific article published in December 2017

Conformational mechanism for the stability of microtubule-kinetochore attachments. ⬇️

scientific article

Dissecting mitosis by RNAi inDrosophila tissue culture cells

scientific article

Dissecting mitosis with laser microsurgery and RNAi in Drosophila cells

scientific article

Drosophila S2 cells as a model system to investigate mitotic spindle dynamics, architecture, and function.

scientific article

Dynein and mast/orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics.

scientific article

Dynein prevents erroneous kinetochore-microtubule attachments in mitosis

scientific article

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

scientific article

Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

scientific article (publication date: 14 May 2001)

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

scientific article published on 17 January 2013

Feedback control of chromosome separation by a midzone Aurora B gradient

scientific article

Fluorescent speckle microscopy in cultured cells.

scientific article published on January 2012

Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells

scientific article

Heterochromatin boundaries are hotspots for de novo kinetochore formation

scientific article published on 19 June 2011

How do kinetochores CLASP dynamic microtubules?

scientific article

Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics

scientific article

Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis ⬇️

scientific article published on September 3, 2012

Imidazole-grafted chitosan-mediated gene delivery: in vitro study on transfection, intracellular trafficking and degradation

scientific article

Improved kymography tools and its applications to mitosis.

scientific article

Inducible fluorescent speckle microscopy

scientific article

Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.

scientific article

Kinetochore regulation: Let there be light.

scientific article published on 14 August 2017

Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis

scientific article

Kinetochore-microtubule interactions during cell division.

scientific article

Kinetochores use a novel mechanism for coordinating the dynamics of individual microtubules.

scientific article

Late mitotic functions of Aurora kinases

scientific article published on 22 April 2016

MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity

scientific article

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function

scientific article published on 16 August 2006

Maturation of the kinetochore-microtubule interface and the meaning of metaphase.

scientific article published on July 2012

Mechanisms of Chromosome Congression during Mitosis.

scientific article published on 17 February 2017

Membrane-based mechanisms of mitotic spindle assembly.

scientific article

Microtubule plus-end tracking proteins and their roles in cell division

scientific article published on January 2014

Miguel Mota (1922-2016)-the kinetochore engine(er).

scientific article

Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila

scientific article published on 25 September 2007

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

scientific article published on 23 April 2015

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

scientific article published on 06 August 2018

Mitotic spindle multipolarity without centrosome amplification.

scientific article

Motor-Dependent and -Independent Roles of CENP-E at Kinetochores: The Cautionary Tale of UA62784 ⬇️

scientific article published on June 24, 2011

Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.

scientific article

N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics.

scientific article published on 18 August 2014

No chromosome left behind: The importance of metaphase alignment for mitotic fidelity

scientific article published on 11 March 2019

Plk1 puts a (Has)pin on the mitotic histone code

scientific article published on 14 February 2014

Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes

scientific article

Prevention and Correction Mechanisms behind Anaphase Synchrony: Implications for the Genesis of Aneuploidy ⬇️

scientific article published on 08 February 2011

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.

scientific article published on 2 May 2017

Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase

scientific article (publication date: 2015)

Robust gap repair in the contractile ring ensures timely completion of cytokinesis.

scientific article published on 13 December 2016

Spatial control of the anaphase-telophase transition

scientific article published in January 2014

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

scientific article published on 19 August 2019

Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

scientific article published on December 2013

Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores.

scientific article published on 06 July 2009

The Tubulin Code in Mitosis and Cancer

scientific article published on 26 October 2020

The Tubulin Code: A Navigation System for Chromosomes during Mitosis. ⬇️

scientific article published on 22 June 2016

The dynamic kinetochore-microtubule interface

scientific article

The dynamic spindle matrix.

scientific article published on February 2014

The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance

scientific article

The perpetual movements of anaphase.

scientific article published on 21 March 2010

The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion

scientific article

Unbiased about chromosome segregation: give me a mechanism and I will make you "immortal".

scientific article published in May 2013

List of works by Helder Maiato

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition.

A chromosome separation checkpoint: A midzone Aurora B gradient mediates a chromosome separation checkpoint that regulates the anaphase-telophase transition.

A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis

An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network

Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis

Aurora Mitochondrialis drives fission during mitosis

CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity ⬇️

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments

Cell Division: NuMA Bears the Load in the Spindle.

Chromator is required for proper microtubule spindle formation and mitosis in Drosophila

Closing the tubulin detyrosination cycle.

Conformational mechanism for the stability of microtubule-kinetochore attachments. ⬇️

Dissecting mitosis by RNAi inDrosophila tissue culture cells

Dissecting mitosis with laser microsurgery and RNAi in Drosophila cells

Drosophila S2 cells as a model system to investigate mitotic spindle dynamics, architecture, and function.

Dynein and mast/orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics.

Dynein prevents erroneous kinetochore-microtubule attachments in mitosis

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

Feedback control of chromosome separation by a midzone Aurora B gradient

Fluorescent speckle microscopy in cultured cells.

Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells

Heterochromatin boundaries are hotspots for de novo kinetochore formation

How do kinetochores CLASP dynamic microtubules?

Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics

Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis ⬇️

Imidazole-grafted chitosan-mediated gene delivery: in vitro study on transfection, intracellular trafficking and degradation

Improved kymography tools and its applications to mitosis.

Inducible fluorescent speckle microscopy

Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.

Kinetochore regulation: Let there be light.

Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis

Kinetochore-microtubule interactions during cell division.

Kinetochores use a novel mechanism for coordinating the dynamics of individual microtubules.

Late mitotic functions of Aurora kinases

MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function

Maturation of the kinetochore-microtubule interface and the meaning of metaphase.

Mechanisms of Chromosome Congression during Mitosis.

Membrane-based mechanisms of mitotic spindle assembly.

Microtubule plus-end tracking proteins and their roles in cell division

Miguel Mota (1922-2016)-the kinetochore engine(er).

Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Mitotic spindle multipolarity without centrosome amplification.

Motor-Dependent and -Independent Roles of CENP-E at Kinetochores: The Cautionary Tale of UA62784 ⬇️

Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.

N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics.

No chromosome left behind: The importance of metaphase alignment for mitotic fidelity

Plk1 puts a (Has)pin on the mitotic histone code

Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes

Prevention and Correction Mechanisms behind Anaphase Synchrony: Implications for the Genesis of Aneuploidy ⬇️

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.

Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase

Robust gap repair in the contractile ring ensures timely completion of cytokinesis.

Spatial control of the anaphase-telophase transition

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores.

The Tubulin Code in Mitosis and Cancer

The Tubulin Code: A Navigation System for Chromosomes during Mitosis. ⬇️

The dynamic kinetochore-microtubule interface

The dynamic spindle matrix.

The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance

The perpetual movements of anaphase.

The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion

Unbiased about chromosome segregation: give me a mechanism and I will make you "immortal".