List of works by Sinisa Savic

'Warning: allergic to penicillin': association between penicillin allergy status in 2.3 million NHS general practice electronic health records, antibiotic prescribing and health outcomes

scientific article published on 01 July 2019

A Case of Adult-Onset Still’s Disease Caused by a Novel Splicing Mutation in TNFAIP3 Successfully Treated With Tocilizumab. ⬇️

scientific article published on 4 July 2018

A Case of SLC29A3 Spectrum Disorder-Unresponsive to Multiple Immunomodulatory Therapies. ⬇️

scientific article published on 23 May 2016

A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype

scientific article published on 04 April 2019

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency ⬇️

scientific article published on 9 November 2015

A new case of Fas-associated death domain protein deficiency and update on treatment outcomes ⬇️

scientific article published on 17 March 2015

A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination ⬇️

scientific article published on 11 December 2018

A novel RELA truncating mutation in familial Behçet's Disease-like mucocutaneous ulcerative condition

scientific article published on 23 September 2020

A novel TNFRSF1A splice mutation associated with increased nuclear factor kappaB (NF-kappaB) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS).

scientific article

A report of novel STIM1 deficiency and 6 year follow up of two previous cases associated with mild immunological phenotype

scholarly article published 18 October 2018

A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients

scientific article published on 05 July 2020

An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7

scientific article published on 21 October 2021

Anakinra as a diagnostic challenge and treatment option for systemic autoinflammatory disorders of undefined etiology

scientific article published on 05 May 2016

Anakinra as a diagnostic challenge and treatment option for systemic autoinflammatory disorders of undefined genetic cause

scientific article published on 28 September 2015

Anaphylaxis associated with general anaesthesia: Challenges and recent advances

Anaphylaxis to sugammadex

scientific article published on 01 January 2014

Antihistamine-resistant chronic spontaneous urticaria remains undertreated: 2-year data from the AWARE study

scientific article published on 31 July 2020

Arthritis in Two Patients With Partial Recombination Activating Gene Deficiency

scientific article published on 05 July 2019

Autoimmune-autoinflammatory rheumatoid arthritis overlaps: a rare but potentially important subgroup of diseases ⬇️

scientific article published in November 2017

Autoinflammatory Disease in the Lung. ⬇️

scientific article published on 19 April 2018

Autoinflammatory diseases: update on classification diagnosis and management ⬇️

scientific article published on 19 September 2016

Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives

scientific article published on August 2012

Bialellic Mutations in Tetratricopeptide Repeat Domain 7A (TTC7A) Cause Common Variable Immunodeficiency-Like Phenotype with Enteropathy

scientific article published on 14 August 2017

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation ⬇️

scientific article published on 8 November 2017

Biallelic mutations in IRF8 impair human NK cell maturation and function ⬇️

scientific article

British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. ⬇️

scientific article published on 25 March 2017

British Society for Immunology/United Kingdom Primary Immunodeficiency Network consensus statement on managing non‐infectious complications of Common Variable Immunodeficiency Disorders

scientific article published on 07 March 2019

COVID-19 meets Cystic Fibrosis: for better or worse?

scientific article published on 01 July 2020

CVID patients with autoimmunity have elevated T cell expression of granzyme B and HLA-DR and reduced levels of Treg cells.

scientific article published on 21 November 2012

Canakinumab for the cryopyrin-associated periodic syndromes

scientific article published in October 2009

Characterising RAG1 and RAG2 with predictive genomics

Chlorhexidine allergy in the perioperative setting: a narrative review

scientific article published on 05 April 2019

Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: A cohort study ⬇️

scientific article published on 21 April 2016

Clinical genetics in 2014: New monogenic diseases span the immunological disease continuum.

scientific article published on 23 December 2014

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

scientific article published on 16 July 2016

Combined Immunodeficiency With Late-Onset Progressive Hypogammaglobulinemia and Normal B Cell Count in a Patient With RAG2 Deficiency

scientific article published on 16 April 2019

Developing a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice and subsequently change antibiotic use

scientific article published on 01 October 2020

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

scientific article published on 02 March 2020

Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients.

scientific article published in October 2012

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry. ⬇️

scientific article published on 16 March 2018

Do defective B cells contribute to reduced Treg cells and autoimmunity in patients with Common Variable Immunodeficiency?

scientific article published on 31 July 2012

Does this patient have periodic fever syndrome?

scientific article published on August 2011

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

scientific article published on 18 September 2019

Evidence of B Cell Clonality and Investigation Into Properties of the IgM in Patients With Schnitzler Syndrome

scientific article published on 03 December 2020

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

scientific article published on 17 May 2013

Excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis

scholarly article published 31 October 2018

Expanding Clinical Phenotype and Novel Insights into the Pathogenesis of ICOS Deficiency

scientific article published on 20 December 2019

Exploratory Study of MYD88 L265P, Rare NLRP3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome

scientific article published on 14 October 2019

FRI0334 Safety of rituximab for remission maintenance in relapsing anca–associated vasculitis: repeat cycles on clinical relapse are associated with low rates of hypogammaglobulinaemia

Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases

scientific article published on January 2012

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. ⬇️

scientific article

Feasibility of abbreviated penicillin de-labelling in the elective surgical patients: the PADLES study – an early report

Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases

scientific article

GRID - Genomics of Rare Immune Disorders: a highly sensitive and specific diagnostic gene panel for patients with primary immunodeficiencies

article

Germline TET2 Loss-Of-Function Causes Childhood Immunodeficiency And Lymphoma

scientific article published on 09 June 2020

Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications. ⬇️

scientific article published on 6 November 2017

Hereditary systemic autoinflammatory diseases and Schnitzler's syndrome

scientific article published on 01 November 2019

Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

scientific article published on 27 January 2012

Home self-administration of omalizumab for chronic spontaneous urticaria. ⬇️

scientific article published on 17 September 2016

Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease

scientific article published on 28 August 2018

Identification of Critical Transcriptomic Signaling Pathways in Patients with H Syndrome and Rosai-Dorfman Disease

scientific article published on 07 December 2020

Incidence of suspected perioperative anaphylaxis: A multicenter snapshot study

scientific article

Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide ⬇️

scientific article published on 6 February 2018

Interleukin-1 Blockade: An Update on Emerging Indications

scientific article

International Retrospective Chart Review of Treatment Patterns in Severe Familial Mediterranean Fever, Tumor Necrosis Factor Receptor-Associated Periodic Syndrome, and Mevalonate Kinase Deficiency/Hyperimmunoglobulinemia D Syndrome ⬇️

scientific article

Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome

scientific article published on 7 June 2012

Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism-UK Single Center Experience ⬇️

scientific article published on 31 October 2017

Ligelizumab for Chronic Spontaneous Urticaria

scientific article published on 01 October 2019

Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap).

scientific article published on December 2008

Mechanistic immunological based classification of rheumatoid arthritis

scientific article published on 11 September 2018

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

scientific article published on 02 August 2019

Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease

scientific article published on 01 July 2020

Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice

scientific article published in 2022

Molecular genetic investigation, clinical features and response to treatment in 21 patients with Schnitzler's syndrome ⬇️

scientific article

Moving towards a systems-based classification of innate immune-mediated diseases

scientific article published on 27 February 2020

Multicentre experience of home omalizumab treatment for chronic spontaneous urticaria

scientific article published on 15 July 2019

Natural killer cell receptor expression in patients with severe and recurrent Herpes simplex virus-1 (HSV-1) infections

scientific article

P01-026 – A case of FMF and hereditary coproporphyria

scientific article

PW02-013 - The role of IL6 and LPS in pathogenesis of TRAPS.

scientific article

PW02-031 - Genetic and clinical manifestations of CAPS.

scientific article

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency

scientific article published on 03 April 2019

Patient and Primary Care Physician Perceptions of Penicillin Allergy Testing and Subsequent Use of Penicillin-Containing Antibiotics: A Qualitative Study

scientific article published on 12 March 2019

Periodic fever syndrome and autoinflammatory diseases

scientific article published on 18 January 2010

Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus ⬇️

scientific article published on 01 April 2018

Predicting Severe Infection and Effects of Hypogammaglobulinemia During Therapy With Rituximab in Rheumatic and Musculoskeletal Diseases

scientific article published on 26 September 2019

Predicting the Occurrence of Variants in RAG1 and RAG2

scientific article published on 06 August 2019

Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency. ⬇️

scientific article published on 22 February 2018

Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part three: Genoa, Italy. 28 September – 01 October 2016.

scientific article published on 30 May 2017

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

scientific article published on 17 July 2020

RNAseq Supports the Molecular Genetic Diagnosis of Late-Onset ADA Deficiency

scientific article published on 16 April 2019

Rationale for Evaluating PDE4 Inhibition for Mitigating against Severe Inflammation in COVID-19 Pneumonia and Beyond

scientific article published on 01 June 2020

Repeat cycles of rituximab on clinical relapse in ANCA-associated vasculitis: identifying B cell biomarkers for relapse to guide retreatment decisions ⬇️

scientific article published on 8 April 2015

Resistant type II cryoglobulinaemic vasculitis successfully treated with bortezomib in a patient with SLE

Response to "Increased awareness of hypogammaglobulinemia after B-cell targeting therapies" by Karim MY

scientific article published on 05 March 2020

Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care ⬇️

scientific article published on 21 July 2015

SAT0482 Risk Factors for Severe Infection and Outcome of Secondary Hypogammaglobulinaemia in Patients with Autoimmune Rheumatic Diseases Treated with Rituximab: Preliminary Results from 400 Patients at A Single Centre: Table 1

article by M.Y. Md Yusof et al published June 2016 in Annals of the Rheumatic Diseases

Selective Response to Omalizumab in a Patient With Concomitant ncMCAS and POTS: What Does it Teach us About the Underlying Disease?

scholarly article by M Kacar et al published 1 August 2018 in Journal of Investigational Allergology and Clinical Immunology

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

scientific article published on 27 October 2020

Sugammadex: the sting in the tail? ⬇️

scientific article published on 14 August 2018

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes ⬇️

scientific article

Teicoplanin allergy - an emerging problem in the anaesthetic allergy clinic ⬇️

scientific article published in October 2015

The Ca sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum ⬇️

scientific article published on 14 January 2019

The Efficacy, Safety and Tolerability of Canakinumab in the Treatment of Familial Mediterranean Fever: A Systematic Review of the Literature

scientific article published on 09 March 2020

The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self

scientific article published on 06 September 2007

The NLRP3 inflammasome, a target for therapy in diverse disease states

scientific article published on March 2010

The United Kingdom Primary Immune Deficiency (UKPID) registry 2012 to 2017

scientific article published on 01 June 2018

The burgeoning field of innate immune-mediated disease and autoinflammation ⬇️

scientific article published on 29 September 2016

The role of dysregulated unfolded protein response and resistance to apoptosis in the pathogenesis of rheumatoid arthritis and non- response to anti-TNF therapies

doctoral thesis

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

scientific article

What is the utility of routine ANA testing in predicting development of biological DMARD-induced lupus and vasculitis in patients with rheumatoid arthritis? Data from a single-centre cohort

scientific article

Whole Genome Sequencing of Primary Immunodeficiency reveals a role for common and rare variants in coding and non-coding sequences

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

scientific article published on 06 May 2020

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