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List of works by John Sharkey

A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology.

scientific article published on 23 August 2006

Acquired QT interval prolongation and HERG: implications for drug discovery and development

scientific article published in October 2004

Acute cocaine administration: effects on local cerebral blood flow and metabolic demand in the rat.

scientific article published in May 1991

Acute cocaine alters cerebrovascular autoregulation in the rat neocortex

scientific article published in January 1993

Advances in small molecules promoting neurotrophic function

scientific article published on 20 April 2007

Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").

scientific article published in January 1991

Alterations in local cerebral glucose utilization following central administration of corticotropin-releasing factor in rats

scientific article published on 01 January 1989

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

scientific article

Analysis of forebrain dopaminergic pathways in HPRT-mice

scientific article published on 01 January 1991

Apoptosis induced by staurosporine alters chaperone and endoplasmic reticulum proteins: Identification by quantitative proteomics

scientific article

Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia

scientific article

Assessment of sensorimotor neglect after occlusion of the middle cerebral artery in the rat.

scientific article

Autoradiographic analysis of muscarinic receptors and choline-uptake mechanisms within foetal basal forebrain transplants.

scientific article published on January 1992

Autoradiographic determination of glucose content and estimation of the lumped constant in intracerebral neuronal tissue transplants ⬇️

scientific article published on January 1, 1992

Behavioural assessment of endothelin-1 induced middle cerebral artery occlusion in the rat.

scientific article published in May 1995

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

scientific article

Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis

scientific article published in October 2000

Cerebrovascular and functional consequences of 5-HT1A receptor activation

scientific article published in July 1991

Cerebrovascular permeability in intracerebral implants of foetal basal forebrain cell suspensions.

scientific article published on January 1991

Characterisation of an experimental model of stroke produced by intracerebral microinjection of endothelin-1 adjacent to the rat middle cerebral artery

scientific article published in August 1995

Characterisation of the Bax-nucleophosmin interaction: the importance of the Bax C-terminus

scientific article

Chronic 3,4-methylenedioxymethamphetamine administration decreases glucocorticoid and mineralocorticoid receptor, but increases 5-hydroxytryptamine1C receptor gene expression in the rat hippocampus

scientific article

Chronic effects of the selective serotoninergic neurotoxin, methylenedioxyamphetamine, upon cerebral function

scientific article published in January 1990

Cocaine binding at sigma receptors.

scientific article

Cocaine inhibits muscarinic cholinergic receptors in heart and brain.

scientific article

Cocaine receptors on dopamine transporters mediate cocaine-reinforced behavior.

scientific article published in January 1988

Comparison of effects of MgCl2 and Gpp(NH)p on antagonist and agonist radioligand binding to adenosine A1 receptors.

scientific article published in August 2003

Comparison of the patterns of altered cerebral glucose utilisation produced by competitive and non-competitive NMDA receptor antagonists

scientific article published in September 1996

Detection of adenosine receptor antagonists in rat brain using a modified radioreceptor assay

scientific article

Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice

scientific journal article

Differential effects of competitive (CGS19755) and non-competitive (MK 801) NMDA receptor antagonists upon local cerebral blood flow and local cerebral glucose utilisation in the rat.

scientific article published in July 1994

Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro

scientific journal article

Dopamine transport sites selectively labeled by a novel photoaffinity probe: 125I-DEEP.

scientific article

Dopamine transporter: solubilization from dog caudate nucleus

scientific article published on 01 January 1989

Endothelin-1 induced middle cerebral artery occlusion: pathological consequences and neuroprotective effects of MK801.

scientific article published in September 1994

Enhanced cerebrovascular responsiveness to hypercapnia following depletion of central serotonergic terminals

scientific article published on 01 July 1995

Evidence for a possible role for serotonergic systems in the control of cerebral blood flow

scientific article published in December 1990

FK 506 protects brain tissue in animal models of stroke.

scientific article published in May 2001

Glycyrrhetinic acid, an inhibitor of 11 beta-hydroxysteroid dehydrogenase, alters local cerebral glucose utilization in vivo

scientific article published in November 1991

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

scientific article published in Nature

Immunosuppressants-ligands as neuroprotectants.

scientific article published in May 2001

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

scientific article published on 02 May 2006

Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia.

scientific article published in October 2004

Molecular mechanisms of neurite growth with AMPA receptor potentiation.

scientific article published on 13 November 2006

Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography

scientific article published in August 1991

Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism.

scientific article published in September 1997

Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor

scientific article published in May 2004

Normal cerebrovascular regulatory mechanisms are present in intracerebral neuronal transplants.

scientific article published on January 1991

Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death.

scientific article

Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat

scientific article published on 01 September 1993

Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques

scientific article published in June 1998

Putative TRP channel antagonists, SKF 96365, flufenamic acid and 2-APB, are non-competitive antagonists at recombinant human α1β2γ2 GABA(A) receptors

scientific article published on 18 February 2012

Serum IL-8 and MCP-1 concentration do not identify patients with enlarging contusions after traumatic brain injury

scientific article published in June 2009

Simple and choice reaction-time performance following occlusion of the anterior cerebral arteries in the rat.

scientific article published in December 1998

Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats

scientific article published in December 1996

The odour span task: a novel paradigm for assessing working memory in mice

scientific article published on 13 November 2006

The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat

scientific journal article

VIP and PACAP receptor pharmacology: a comparison of intracellular signaling pathways

scientific article published in July 2006

[125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor

scientific article published in January 1989

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

scientific article

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