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List of works by Roberto Spreafico

A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment

scientific article published on 12 December 2014

A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples

scientific article

Advances in Genomics for Drug Development

scientific article published on 15 August 2020

Antibody-Mediated Rejection in Lung Transplantation: Clinical Outcomes and Donor-Specific Antibody Characteristics

scientific article published on 4 February 2016

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

scientific article

Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

scientific article published on July 2013

Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors

scientific article

Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation

scientific article published on 08 December 2016

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

scientific article published on 25 November 2019

Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4+ T cell activation pathways.

scientific article

Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.

scientific article

Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy

scientific article published on 04 February 2014

Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis

scientific article published on 27 September 2013

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

scientific article

Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells

scientific article published on 28 March 2013

IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions

scientific article published on 19 September 2013

Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance.

scientific article

Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms

scientific article

Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei.

scientific article

Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing

scientific article published on 01 October 2021

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.

scientific article published on 13 July 2017

Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors.

scientific article published on 12 July 2016

Regulatory T-Cell Therapy in Transplantation and Severe Autoimmunity.

scientific article

Similarities and differences of innate immune responses elicited by smooth and rough LPS

article

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

scientific article published on 09 April 2020

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

scientific article published on 16 June 2016

Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor

scientific article published on 24 April 2019

The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum Adjuvants

scientific article published on 28 November 2016

The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants.

scientific article published on March 2010

The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae.

scientific article published on April 2017

Training the 21st Century Immunologist.

scientific article published on 21 April 2015

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

scientific article

Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.

scientific article published on 4 November 2011

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