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List of works by Darren C. Tomlinson

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges ⬇️

scientific article published on July 31, 2012

A high-throughput assay to identify modifiers of premature chromosome condensation ⬇️

scientific article

A place for precision medicine in bladder cancer: targeting the FGFRs ⬇️

scientific article

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications ⬇️

scientific article

Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using <i>In Vitro</i> and <i>In Vivo</i> Models

scientific article published on 23 February 2022

Affimer proteins are versatile and renewable affinity reagents ⬇️

scientific article

Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells ⬇️

scientific article published on 26 April 2018

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action ⬇️

scientific article

Affimer reagents as tools in diagnosing plant virus diseases

article

Altered Splicing of FGFR1 Is Associated with High Tumor Grade and Stage and Leads to Increased Sensitivity to FGF1 in Bladder Cancer ⬇️

scientific article published on October 1, 2010

Alternative reagents to antibodies in imaging applications ⬇️

scientific article published on 27 July 2017

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines

scientific article published on November 2005

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes ⬇️

scientific journal article

Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance

scientific article published in February 2017

Antibody mimetic receptor proteins for label-free biosensors. ⬇️

scientific article published in February 2015

Chapter Eight - Ubiquitin-Mediated Regulation of Cellular Responses to Vascular Endothelial Growth Factors.

scientific article

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests

scientific article published on 03 June 2020

Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies ⬇️

scientific article

Development of an Affimer-antibody combined immunological diagnosis kit for glypican-3. ⬇️

scientific article

Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate

scientific journal article

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

scientific article

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

scientific article

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma

scientific article published in August 2005

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes.

scientific article published on 24 April 2010

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation

scientific article published on 19 September 2018

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

scientific article

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

scientific article published on 19 May 2009

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology ⬇️

scientific article published on 14 November 2017

High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers ⬇️

scientific article (publication date: 2014)

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk ⬇️

scientific article published on 09 March 2017

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

scientific article

Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers ⬇️

scientific article published on 20 February 2017

Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection ⬇️

scientific article published on 14 November 2017

Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.

scientific article published on 26 March 2007

Label-free electrochemical impedance biosensor to detect human interleukin-8 in serum with sub-pg/ml sensitivity. ⬇️

scientific article

Mechanisms of FGFR3 actions in endocrine resistant breast cancer ⬇️

scientific article published on August 29, 2011

Multidrug-resistant breast cancer: current perspectives ⬇️

scientific article published on 10 January 2014

Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer ⬇️

scientific article published on 20 February 2018

Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis. ⬇️

scientific article

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

scientific article published on 30 June 2021

Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements

scientific article (publication date: April 2004)

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions ⬇️

scientific article published on 30 January 2015

Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions ⬇️

scientific article published on 4 February 2015

Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection. ⬇️

scientific article published on 21 February 2018

Site-Specific Labeling of Affimers for DNA-PAINT Microscopy ⬇️

scientific article published on 15 July 2018

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo. ⬇️

scientific article

Sonic hedgehog regulates prostatic growth and epithelial differentiation

scientific journal article

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

scientific article

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis ⬇️

scientific article (publication date: 2015)

The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function ⬇️

scientific article published on 30 January 2014

Trivalent Gd-DOTA reagents for modification of proteins ⬇️

scientific article

Tumor heterogeneity of fibroblast growth factor receptor 3 (FGFR3) mutations in invasive bladder cancer: implications for perioperative anti-FGFR3 treatment. ⬇️

scientific article published on 18 April 2016

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function ⬇️

scientific article

Ultraefficient Cap-Exchange Protocol To Compact Biofunctional Quantum Dots for Sensitive Ratiometric Biosensing and Cell Imaging ⬇️

scientific article published on 19 April 2017

Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases ⬇️

scientific article published on 2 February 2017

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis ⬇️

scientific article published on 3 April 2016

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. ⬇️

scientific article published on 13 October 2015

Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells ⬇️

scientific article published in January 2014

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease

scientific article published on 14 April 2015

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