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List of works by Christopher Winrow

Adult mouse brain gene expression patterns bear an embryologic imprint

scientific article

Altered sleep and affect in the neurotensin receptor 1 knockout mouse

scientific article

Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation

scientific article

Calreticulin modulates the in vitro DNA binding but not the in vivo transcriptional activation by peroxisome proliferator-activated receptor/retinoid X receptor heterodimers

scientific article published on 01 June 1995

Capacity of UV‐lrradiated Human Fibroblasts to Support Adenovirus DNA Synthesis Correlates with Transcription‐Coupled Repair and is Reduced in SV40‐Transformed Cells and Cells Expressing Mutant p53 ⬇️

scientific article published on November 1, 1997

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

scientific article published on 14 April 2009

Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression

scientific article published on 25 July 2018

Cross-talk between orphan nuclear hormone receptor RZRalpha and peroxisome proliferator-activated receptor alpha in regulation of the peroxisomal hydratase-dehydrogenase gene

scientific article published on 01 November 1998

Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes.

scientific article published on February 1996

Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.

scientific article published on 8 February 2010

Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators

scientific article

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

scientific article published on January 2014

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).

scientific article

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.

scientific article published on 25 May 2010

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia

scientific article

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties

scientific article

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.

scientific article published in July 2009

Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements

scientific article published on 6 January 2015

Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant

scientific article published on 23 December 2014

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia

scientific article

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.

scientific article published on 24 December 2013

Evidence that mouse brain neuropathy target esterase is a lysophospholipase

scientific article

Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties

scientific article

Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake

scientific article

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

scientific article published on 15 January 2016

International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology

scientific article

Interplay of the peroxisome proliferator-activated receptor and the thyroid hormone receptor-signaling pathways in regulating peroxisome proliferator-responsive genes

scientific article published on 01 December 1996

Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity

scientific article (publication date: April 2003)

New approach for analyzing self-reporting of insomnia symptoms reveals a high rate of comorbid insomnia across a wide spectrum of chronic diseases

scientific article published on 21 August 2015

OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.

scientific article published on 19 August 2015

Oiling the pipeline: the path from genomics to drug discovery for brain disease

scientific article

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

scientific article

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

scientific article

Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition

scientific article published in April 2013

Orexin receptors as therapeutic drug targets

scientific article published on January 2012

Orexin receptors: pharmacology and therapeutic opportunities

scientific article

Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia

scientific article

Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain

scientific article published in March 2016

Pharmacological validation of candidate causal sleep genes identified in an N2 cross

scientific article

Preclinical and clinical results of dual orexin receptor antagonist, suvorexant (BELSOMRA(®)), a novel therapeutic agent for insomnia.

scientific article

Proline bis-amides as potent dual orexin receptor antagonists

scientific article

Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist

scientific article

Refined anatomical isolation of functional sleep circuits exhibits distinctive regional and circadian gene transcriptional profiles

scientific article

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

scientific article

TASK-3 as a potential antidepressant target

scientific article published on 16 August 2011

The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.

scientific article published on 26 April 2017

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

scientific article

The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated t

scientific article

Uncovering the genetic landscape for multiple sleep-wake traits

scientific article

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