List of works - Patrick Collombat

A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells

scientific article

A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX

scientific journal article

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes

scientific article

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

scientific article

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity

scientific article published on 21 July 2009

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage

scientific article

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons

scientific article published on October 2008

Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis.

scientific article published on 12 October 2017

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

scientific article published on April 2007

Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons.

scientific article published on April 2014

From pancreas morphogenesis to β-cell regeneration

scientific article published on January 2013

Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas

scientific article published in 2013

Generation of animals allowing the conditional inactivation of the Pax4 gene.

scientific article published on 21 June 2012

Genetic determinants of pancreatic epsilon-cell development

scientific article published in October 2005

Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum

scientific article published on January 2008

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

scientific article

In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.

scientific article published on January 2005

In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes

scientific article published on October 2011

Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity

scientific article published in PLoS ONE

Pancreatic beta-cells: from generation to regeneration

scientific article

Pax4 acts as a key player in pancreas development and plasticity.

scientific article published on 28 August 2015

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker

scientific article published on 11 December 2015

Reprogramming into pancreatic endocrine cells based on developmental cues

scientific article published on 16 December 2009

Reprogramming pancreatic cells to β cells

scientific article

Role of ghrelin in pancreatic development and function

scientific article published on 01 September 2018

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

scientific article published on 29 March 2006

Specifying pancreatic endocrine cell fates.

scientific article published on 25 May 2006

The homeobox gene Arx is a novel positive regulator of embryonic myogenesis.

scientific article

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice

scientific article

The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells

scientific article (publication date: October 2013)

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

scientific journal article

[Pax4 transdifferentiates glucagon-secreting alpha cells to insulin-secreting beta endocrine pancreatic cells]

scientific article published on 01 August 2009

List of works by Patrick Collombat

A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells

A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons

Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis.

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons.

From pancreas morphogenesis to β-cell regeneration

Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas

Generation of animals allowing the conditional inactivation of the Pax4 gene.

Genetic determinants of pancreatic epsilon-cell development

Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.

In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes

Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity

Pancreatic beta-cells: from generation to regeneration

Pax4 acts as a key player in pancreas development and plasticity.

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker

Reprogramming into pancreatic endocrine cells based on developmental cues

Reprogramming pancreatic cells to β cells

Role of ghrelin in pancreatic development and function

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

Specifying pancreatic endocrine cell fates.

The homeobox gene Arx is a novel positive regulator of embryonic myogenesis.

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice

The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

[Pax4 transdifferentiates glucagon-secreting alpha cells to insulin-secreting beta endocrine pancreatic cells]