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List of works by H. Leighton Grimes

A 2-way miRror of red blood cells and leukemia.

scientific article published in February 2015

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

scientific article published on 13 June 2016

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap.

scientific article published on 13 March 2018

A primer on single-cell genomics in myeloid biology

scientific article published on 12 November 2020

ATF3 is a novel regulator of mouse neutrophil migration

scientific article

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

scientific article published on 13 May 2019

Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor

scientific article

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

scientific article

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

scientific article published on 13 February 2020

Author Correction: Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

scientific article published on 01 May 2019

Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

scientific article published on 30 March 2011

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

scientific journal article

Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents

scientific article

Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation

scientific article published on 26 April 2019

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

scientific article published on 22 June 2020

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

scientific article

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

scientific article

Counting the cost of lineage decisions

scientific article

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

scientific article published in Journal of Biological Chemistry

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

scientific article

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation

scientific article

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

scientific article published on 01 November 2019

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology

scientific article published on 7 November 2012

Effect of captopril therapy on lymphocyte potassium and magnesium concentrations in patients with congestive heart failure

scientific article published on 01 January 1992

Effect of prolonged nifedipine or captopril therapy on lymphocyte magnesium and potassium levels in hypertension

scientific article published on 01 January 1993

Enhanced MAPK signaling is essential for CSF3R-induced leukemia

scientific article published on 29 December 2016

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5

scientific article

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome

scientific article published on 13 October 2016

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.

scientific article

Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers

article

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

scientific article

Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor

scientific article published in August 1996

Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1

scientific article

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

scientific article published on 31 October 2011

Gfi1 integrates progenitor versus granulocytic transcriptional programming

scientific article published on 03 April 2009

Gfi1 regulates miR-21 and miR-196b to control myelopoiesis

scientific article

Gfi1-cells and circuits: unraveling transcriptional networks of development and disease

scientific article published on July 2010

Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes

scientific article published on 01 October 2004

Graft tolerance and acceptance in xenotransplantation

article published in 2002

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes.

scientific article published in November 2017

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

scientific article

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells.

scientific article

Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment

scientific article published in March 2003

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

scientific article

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

scientific article published on 01 January 2020

Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS.

scientific article published on August 2008

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

scientific article

Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells

scientific article

In situ mapping identifies distinct vascular niches for myelopoiesis

scientific article

Intranuclear staining of proteins in heterogeneous cell populations and verification of nuclear localization by flow cytometric analysis

scientific article published on 01 August 2003

Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.

scientific article

Loss of GFI1 impairs pulmonary neuroendorine cell proliferation, but the neuroendocrine phenotype has limited impact on post-naphthalene airway repair

scientific article published on April 2007

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice

scientific article

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

scientific article published in Nature Communications

MIR-23A microRNA cluster inhibits B-cell development.

scientific article

Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment.

scientific article

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

scientific article

MicroRNA in Myelopoiesis and Myeloid Disorders

article published in 2013

MicroRNAs in the midst of myeloid signal transduction.

scientific article published on February 2012

Mouse models of neutropenia reveal progenitor-stage-specific defects

scientific article published on 22 April 2020

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

scientific article published on 6 March 2008

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

scientific article

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network

scientific article

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

scientific article published on 19 September 2014

Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.

scientific article

Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.

scientific article published on 27 December 2017

P63 expression in lung carcinoma: a tissue microarray study of 408 cases

scientific article

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes

scientific article published on 23 August 2018

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells

scientific article

Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors

scientific article published on 09 April 2019

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

scientific article

RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.

scientific article published on 24 June 2011

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML

scientific article published on 10 May 2019

Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts

scientific journal article

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

scientific article

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

scientific article published on 11 August 2009

S6K1 determines the metabolic requirements for BCR-ABL survival.

scientific article

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.

scientific article published on 29 November 2017

SKI controls MDS-associated chronic TGF-β signaling, aberrant splicing, and stem cell fitness

scientific article published on 24 September 2018

STAT5 is critical to maintain effector CD8+ T cell responses.

scientific article

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.

scientific article published on 12 April 2018

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.

scientific article published on 31 August 2016

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

scientific article

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

scientific article published on 01 August 2004

Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells

scientific article

Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia

scientific article

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

scientific article published on 16 November 2016

The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity

scientific article

The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal

scientific article published on November 1996

The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death

scientific article published on December 1996

The Gfi-1B Proto-Oncoprotein Represses p21WAF1 and Inhibits Myeloid Cell Differentiation ⬇️

scientific article published on May 1, 1998

The Human Cell Atlas bone marrow single-cell interactive web portal

scientific article published on 21 September 2018

The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification

scientific article published on 01 December 2018

The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification

scientific article published on 01 November 2018

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation

scientific article published on 4 August 2017

The growth factor independence-1 transcription factor: new functions and new insights.

scientific article

The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG

scientific article published on 07 October 2020

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.

scientific article published on 28 August 2012

The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis

scientific article published on 13 July 2017

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival

scientific journal article

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

scientific article published on 16 December 2013

Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors

scientific article published on 05 July 2018

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

scientific article published on 27 August 2013

Transcription factor RUNX1 promotes survival of acute myeloid leukemiacells.

scientific article published in November 2013

Transcriptional Control of Stem and Progenitor Potential

scientific article published on 26 June 2015

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

scientific article

Unraveling bone marrow architecture

scientific article published on 01 January 2020

Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells.

scientific article

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

scientific article

cellHarmony: Cell-level matching and comparison of single-cell transcriptomes

cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes

scientific article published on 01 December 2019

mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression ⬇️

scientific article published on July 15, 2013

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential

scientific article published on 11 July 2018

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