List of works by Guanglei Zhuang

A VEGF-dependent gene signature enriched in mesenchymal ovarian cancer predicts patient prognosis.

scientific article published on 08 August 2016

A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis.

scientific article

Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway

scientific article published on 24 May 2016

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

scientific article published on 4 August 2013

BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1.

scientific article published on January 2016

Clinicopathological, microenvironmental and genetic determinants of molecular subtypes in KEAP1/NRF2-mutant lung cancer

scientific article published on 04 December 2018

Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer

scientific article

Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics

scientific article published on 14 March 2018

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer

scientific article published on 12 November 2015

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

scientific article published on 15 January 2018

Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells.

scientific article

Effects of cancer-associated EPHA3 mutations on lung cancer.

scientific article published on 24 July 2012

Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.

scientific article published on 22 December 2009

Eph receptors and Ephrins in cancer: common themes and controversies.

scientific article published on December 2008

Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis

scientific journal article

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy

scientific article

Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancer

scientific article published on 07 January 2019

Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies.

scientific article published on 17 May 2013

Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.

scientific article

Lin28B promotes melanoma growth by mediating a microRNA regulatory circuit

scientific article published on 12 June 2015

Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells.

scientific article published on 3 November 2014

Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death

scientific article published on 30 July 2018

Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy

scientific article published on 02 October 2020

Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response

scientific article

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment

scientific article published on 25 March 2013

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase.

scientific article published on 12 February 2018

Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.

scientific article published on 15 January 2008

PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

scientific article published on 03 May 2019

Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases

scientific article published on 16 April 2013

Preclinical Efficacy and Molecular Mechanism of Targeting CDK7-Dependent Transcriptional Addiction in Ovarian Cancer.

scientific article published in June 2017

Prevalence and clonality of synchronous primary carcinomas in the bladder and prostate

scientific article published on 11 October 2017

Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation

scientific article published on 29 November 2006

Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics.

scientific article

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

scientific article published on 10 October 2017

Stroma-associated master regulators of molecular subtypes predict patient prognosis in ovarian cancer

scientific article

TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.

scientific article

TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer

scientific article published on 02 February 2017

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.

scientific article

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade

scientific article published on 11 August 2021

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