List of works - Jan Pravsgaard Christensen

Accessing complexity: the dynamics of virus-specific T cell responses.

scientific article

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin

scientific article published on 12 October 2012

Diminished primary and secondary influenza virus-specific CD8(+) T-cell responses in CD4-depleted Ig(-/-) mice.

scientific article

CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system

scientific article published in April 2006

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice

scientific article published in October 1996

CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection

scientific article published on 04 September 2009

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells

scientific article published on 01 February 1999

The role of CC chemokine receptor 5 in antiviral immunity

scientific article published on 01 February 2002

Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

scientific article

Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus

scientific article published in November 1997

MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines

article published in 2008

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination

scientific article

Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome

scientific article

Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3.

scientific article published in May 2004

Adenoviral vaccination combined with CD40 stimulation and CTLA-4 blockage can lead to complete tumor regression in a murine melanoma model

article

High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development

scientific article published in September 2002

Quality of the Transgene-Specific CD8+ T Cell Response Induced by Adenoviral Vector Immunization Is Critically Influenced by Virus Dose and Route of Vaccination

scientific article published on March 8, 2010

CD8+ T cells complement antibodies in protecting against yellow fever virus

scientific article

The role of CD4+ T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice

scientific article published in October 1994

Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4+T-cell-independent CD8+T-cell-mediated tumor control

scholarly article by Maria R. Sorensen et al published October 2009 in European Journal of Immunology

Deficient CD4+ T cell priming and regression of CD8+ T cell functionality in virus-infected mice lacking a normal B cell compartment

scientific article published in November 2003

Lymphocytic choriomeningitis virus infection is associated with long-standing perturbation of LFA-1 expression on CD8+ T cells

scientific article published in July 1995

Enhanced and Sustained CD8+ T Cell Responses with an Adenoviral Vector-Based Hepatitis C Virus Vaccine Encoding NS3 Linked to the MHC Class II Chaperone Protein Invariant Chain

scientific article published on January 21, 2011

Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus

scientific article published in December 1999

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus.

scientific article published in November 1998

Virus-activated T cells regulate expression of adhesion molecules on endothelial cells in sites of infection

scientific article

Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity

scientific article

Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines

scientific article

Alpha 4 integrin directs virus-activated CD8+ T cells to sites of infection

scientific article

Sensitization to Lipopolysaccharide in Mice with Asymptomatic Viral Infection: Role of T Cell‐Dependent Production of Interferon–γ

article

Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells

scientific article published in September 2003

Role of interferon-gamma in the pathogenesis of LCMV-induced meningitis: unimpaired leucocyte recruitment, but deficient macrophage activation in interferon-gamma knock-out mice

scientific article

Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice

scientific article

Expression of type 3 complement receptor on activated CD8+ T cells facilitates homing to inflammatory sites

scientific article published on 01 September 1994

The importance of lytic and nonlytic immune responses in viral infections

article

Qualitative and quantitative analysis of adenovirus type 5 vector-induced memory CD8 T cells: not as bad as their reputation.

scientific article published on 27 March 2013

Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

scientific article

Comparison of vaccine-induced effector CD8 T cell responses directed against self- and non-self-tumor antigens: implications for cancer immunotherapy

scientific article published on 9 September 2013

T-cell intrinsic expression of MyD88 is required for sustained expansion of the virus-specific CD8+ T-cell population in LCMV-infected mice

scientific article published in February 2009

Rapid and sustained CD4+ T-cell-independent immunity from adenovirus-encoded vaccine antigens

scientific article published on 01 June 2007

Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model

scientific article

The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

scientific article

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

scientific journal article

Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade

scientific article published in January 2009

Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses

scientific article (publication date: 2012)

Role of CD28 co-stimulation in generation and maintenance of virus-specific T cells

scientific article published in July 2002

Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus

scientific article published in February 2007

Host factors influencing viral persistence.

scientific article

Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis

article

List of works by Jan Pravsgaard Christensen

Accessing complexity: the dynamics of virus-specific T cell responses.

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin

Diminished primary and secondary influenza virus-specific CD8(+) T-cell responses in CD4-depleted Ig(-/-) mice.

CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice

CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells

The role of CC chemokine receptor 5 in antiviral immunity

Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus

MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination

Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome

Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3.

Adenoviral vaccination combined with CD40 stimulation and CTLA-4 blockage can lead to complete tumor regression in a murine melanoma model

High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development

Quality of the Transgene-Specific CD8+ T Cell Response Induced by Adenoviral Vector Immunization Is Critically Influenced by Virus Dose and Route of Vaccination

CD8+ T cells complement antibodies in protecting against yellow fever virus

The role of CD4+ T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice

Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4+T-cell-independent CD8+T-cell-mediated tumor control

Deficient CD4+ T cell priming and regression of CD8+ T cell functionality in virus-infected mice lacking a normal B cell compartment

Lymphocytic choriomeningitis virus infection is associated with long-standing perturbation of LFA-1 expression on CD8+ T cells

Enhanced and Sustained CD8+ T Cell Responses with an Adenoviral Vector-Based Hepatitis C Virus Vaccine Encoding NS3 Linked to the MHC Class II Chaperone Protein Invariant Chain

Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus.

Virus-activated T cells regulate expression of adhesion molecules on endothelial cells in sites of infection

Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity

Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines

Alpha 4 integrin directs virus-activated CD8+ T cells to sites of infection

Sensitization to Lipopolysaccharide in Mice with Asymptomatic Viral Infection: Role of T Cell‐Dependent Production of Interferon–γ

Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells

Role of interferon-gamma in the pathogenesis of LCMV-induced meningitis: unimpaired leucocyte recruitment, but deficient macrophage activation in interferon-gamma knock-out mice

Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice

Expression of type 3 complement receptor on activated CD8+ T cells facilitates homing to inflammatory sites

The importance of lytic and nonlytic immune responses in viral infections

Qualitative and quantitative analysis of adenovirus type 5 vector-induced memory CD8 T cells: not as bad as their reputation.

Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

Comparison of vaccine-induced effector CD8 T cell responses directed against self- and non-self-tumor antigens: implications for cancer immunotherapy

T-cell intrinsic expression of MyD88 is required for sustained expansion of the virus-specific CD8+ T-cell population in LCMV-infected mice

Rapid and sustained CD4+ T-cell-independent immunity from adenovirus-encoded vaccine antigens

Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model

The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade

Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses

Role of CD28 co-stimulation in generation and maintenance of virus-specific T cells

Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus

Host factors influencing viral persistence.

Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis