List of works - Holger Heine

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms

scientific article published on 24 April 2019

Accumulation of inhibitory kappaB-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A.

scientific article

Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties

scientific article published on 3 May 2007

Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto

scientific article

An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments

scientific article published on 19 June 2019

Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties.

scientific article published on 25 June 2008

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

scientific article

Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.

scientific article published on March 2005

CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex

scientific article

Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2

scientific article published on 11 June 2011

Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster

scientific article

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation

scholarly article by Alessio Borio et al published 23 October 2018 in ChemMedChem

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects.

scientific article

Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC.

scientific article

Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization

scientific article published on 01 March 2006

Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice

scientific article published on February 2013

Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells

scientific article

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

scientific article

In vitro-Generated Viral Double-Stranded RNA in Contrast to Polyinosinic : Polycytidylic Acid Induces Interferon-alpha in Human Plasmacytoid Dendritic Cells

scientific article published on 01 April 2006

Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease

scientific article

Induction of various immune modulatory molecules in CD34(+) hematopoietic cells.

scientific article published on 23 January 2004

Innate Immunity of Plants, Animals, and Humans

article

Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays

scientific article published on January 2007

Isolation of Enterococcus faecium NM113, Enterococcus faecium NM213 and Lactobacillus casei NM512 as novel probiotics with immunomodulatory properties

scientific article

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

scientific article published on 27 April 2005

Lipopeptide structure determines TLR2 dependent cell activation level

scientific article

Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.

scientific article

Molecular mechanisms of endotoxin activity

scientific article published in 1995

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

scientific article published on 08 January 2020

ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.

scientific article published on 12 May 2015

RNA is taking its Toll: Impact of RNA-specific Toll-like receptors on health and disease

scientific article published on 17 December 2018

Recognition of bacterial products by toll-like receptors

scientific article

Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide.

scientific article

Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma

scientific article published on 27 September 2005

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

scientific article published on January 2007

S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection

scientific article

Salmonella enterica serovar Typhimurium ΔmsbB triggers exacerbated inflammation in Nod2 deficient mice.

scientific article

Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595

Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope.

scientific article published on January 2008

Structural polymorphism and endotoxic activity of synthetic phospholipid-like amphiphiles

scientific article published in April 2004

Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T.

scientific article

Synthesis of biotinylated muramyl tripeptides with NOD2-stimulating activity.

scientific article published on 9 April 2011

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

scientific article

THE INTERACTION OF BACTERIAL LIPOPEPTIDES WITH TOLL-LIKE RECEPTOR 2 HETERODIMERS

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides

scientific article published in Journal of Biological Chemistry

TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

scientific article published on 28 March 2008

TLRs, NLRs and RLRs: innate sensors and their impact on allergic diseases--a current view.

scientific article published on 30 April 2011

The Lipid A from the Lipopolysaccharide of the Phototrophic Bacterium <i>Rhodomicrobium vannielii</i> ATCC 17100 Revisited

scientific article published on 29 December 2020

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

scientific article

The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide.

scientific article

The generalized endotoxic principle

scientific article published in June 2003

The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells

scientific article

The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121.

scientific article published in August 2012

Toll-like receptor 6-independent signaling by diacylated lipopeptides

scientific article published in January 2005

Toll-like receptor recognition of lipoglycans, glycolipids and lipopeptides

Toll-like receptors and their function in innate and adaptive immunity

scientific article

Total Synthesis of Five Lipoteichoic acids of Clostridium difficile.

scientific article

List of works by Holger Heine

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms

Accumulation of inhibitory kappaB-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A.

Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties

Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto

An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments

Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties.

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.

CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex

Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2

Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects.

Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC.

Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization

Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice

Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

In vitro-Generated Viral Double-Stranded RNA in Contrast to Polyinosinic : Polycytidylic Acid Induces Interferon-alpha in Human Plasmacytoid Dendritic Cells

Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease

Induction of various immune modulatory molecules in CD34(+) hematopoietic cells.

Innate Immunity of Plants, Animals, and Humans

Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays

Isolation of Enterococcus faecium NM113, Enterococcus faecium NM213 and Lactobacillus casei NM512 as novel probiotics with immunomodulatory properties

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

Lipopeptide structure determines TLR2 dependent cell activation level

Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.

Molecular mechanisms of endotoxin activity

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.

RNA is taking its Toll: Impact of RNA-specific Toll-like receptors on health and disease

Recognition of bacterial products by toll-like receptors

Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide.

Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection

Salmonella enterica serovar Typhimurium ΔmsbB triggers exacerbated inflammation in Nod2 deficient mice.

Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595

Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope.

Structural polymorphism and endotoxic activity of synthetic phospholipid-like amphiphiles

Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T.

Synthesis of biotinylated muramyl tripeptides with NOD2-stimulating activity.

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

THE INTERACTION OF BACTERIAL LIPOPEPTIDES WITH TOLL-LIKE RECEPTOR 2 HETERODIMERS

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides

TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

TLRs, NLRs and RLRs: innate sensors and their impact on allergic diseases--a current view.

The Lipid A from the Lipopolysaccharide of the Phototrophic Bacterium <i>Rhodomicrobium vannielii</i> ATCC 17100 Revisited

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide.

The generalized endotoxic principle

The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells

The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121.

Toll-like receptor 6-independent signaling by diacylated lipopeptides

Toll-like receptor recognition of lipoglycans, glycolipids and lipopeptides

Toll-like receptors and their function in innate and adaptive immunity

Total Synthesis of Five Lipoteichoic acids of Clostridium difficile.