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List of works by Kirill Alexandrov

"Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors

scientific article

A cell-free approach to accelerate the study of protein-protein interactions in vitro.

scientific article published on October 2013

A generic building block for C- and N-terminal protein-labeling and protein-immobilization

scientific article published on 24 May 2006

A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins

scientific article published on 01 January 2005

Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II

scientific article (publication date: 9 January 2001)

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells

scientific article published on 08 September 2020

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

scientific article

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

scientific article

Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.

scientific article published on 15 December 2010

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

scientific article published in Journal of Biological Chemistry

Boolean Logic Networks Mimicked with Chimeric Enzymes Activated/Inhibited by Several Input Signals

scientific article published on 01 April 2020

C-Terminal Fluorescence Labeling of Proteins for Interaction Studies on the Single-Molecule Level

scientific article published on 01 June 2006

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

scientific article (publication date: 2013)

Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli

scientific journal article

Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase

scientific article published on 01 October 1999

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

scientific article

Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers.

scientific article published on 24 May 2007

Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals

scientific article published on 30 June 2020

Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens

scientific article published on 27 January 2014

Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins

scientific article

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1

scientific article (publication date: 2003)

Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase

scientific article (publication date: November 2001)

Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

scientific article published in 2021

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

scientific article

Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae

scientific article published on 25 March 2005

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

scientific article

Diels-Alder ligation and surface immobilization of proteins.

scientific article

Diels–Alder Ligation of Peptides and Proteins

Diversity and phylogeny of insect trypanosomatids based on small subunit rRNA genes: polyphyly of Leptomonas and Blastocrithidia.

scientific article published in March 2001

Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate

scientific article

Engineering and exploiting synthetic allostery of NanoLuc luciferase

scientific article published on 10 February 2022

Exploiting the Substrate Tolerance of Farnesyltransferase for Site-Selective Protein Derivatization

scholarly article by Uyen T. T. Nguyen published in March 2007

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae

scientific article

Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis

scientific article published on 18 May 2009

Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro

scientific article

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

scientific article published in Nature

Generalizable Protein Biosensors Based on Synthetic Switch Modules

scientific article published on 10 May 2019

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis

scientific article

Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids

scientific article published in March 2006

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex

scientific article

Intein-mediated construction of a library of fluorescent Rab GTPase probes

scientific article

Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro

scientific article

Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators

scholarly article

Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates

scientific article published in May 2002

Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae

scientific article published on 25 April 2006

Leishmania cell-free protein expression system.

scientific article

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

scientific article published on October 2006

Mapping Interactions among Cell-Free Expressed Zika Virus Proteins

scientific article published on 09 March 2020

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

scientific article published on August 1994

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

scientific article

Moderate discrimination of REP-1 between Rab7⋅GDP and Rab7⋅GTP arises from a difference of an order of magnitude in dissociation rates1

scholarly article by Kirill Alexandrov published in April 1998

Nocardiopsins: new FKBP12-binding macrolide polyketides from an Australian marine-derived actinomycete, Nocardiopsis sp.

scientific article published in March 2010

Non-pathogenic trypanosomatid protozoa as a platform for protein research and production

scientific article published on 01 July 2002

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

scientific article

Organization and Function of the Rab Prenylation and Recycling Machinery

Oriented Immobilization of Farnesylated Proteins by the Thiol-Ene Reaction

scientific article published on 01 February 2010

Phosphoisoprenoid Binding Specificity of Geranylgeranyltransferase Type II

scientific article published on 01 October 2000

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

scientific article published on 23 October 2001

Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases.

scientific article

Production of eukaryotic cell-free lysate from Leishmania tarentolae

scientific article published in January 2014

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

scientific article

Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI

scientific article

Rab GTPase prenylation hierarchy and its potential role in choroideremia disease

scientific article

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases

scientific article

Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation

scientific article published on May 2006

Semi-synthetic Rab proteins as tools for studying intermolecular interactions

scientific article published on 01 February 2000

Site-Selective Protein Immobilization by Staudinger Ligation

scientific article published on 01 February 2006

Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides.

scientific article published in November 2006

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

scientific article

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

scientific article

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

scientific article (publication date: February 2003)

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

scientific article

Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation

scientific article published on 24 February 2009

Structure-guided development of selective RabGGTase inhibitors

scientific article

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

scientific article

Subunit organisation of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes

scientific article (publication date: 2013)

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

scientific article published on 01 April 2005

Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

scientific article published in January 2007

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

scientific article published in December 2004

Towards the construction of expressed proteomes using a Leishmania tarentolae based cell-free expression system

scientific article

Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins

scientific article published in June 2001

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