List of works - David Hildeman

A major role for Bim in regulatory T cell homeostasis.

scientific article

A prospective, iterative, adaptive trial of carfilzomib-based desensitization

scientific article published on 23 October 2019

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

scientific article published on June 2002

Activation changes the spectrum but not the diversity of genes expressed by T cells.

scientific article published on October 1999

An adenoviral vector for probing promoter activity in primary immune cells

scientific article

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

scientific article published on 6 April 2004

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Apoptosis and the homeostatic control of immune responses

scientific article

Assessment of CD4+ and CD8+ T Cell Responses Using MHC Class I and II Tetramers ⬇️

scientific article published on January 1, 2013

Bax does not have to adopt its final form to drive T cell death

scientific article

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins

scientific article published on 15 August 2014

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

scientific journal article

C5a negatively regulates toll-like receptor 4-induced immune responses

scientific article

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

scientific journal article

Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?

scientific article

Control of Bcl-2 expression by reactive oxygen species

scientific article

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

scientific article

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation

scientific article

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.

scientific article published on 20 January 2011

Dying to protect: cell death and the control of T-cell homeostasis.

scientific article

Eliminating encephalitogenic T cells without undermining protective immunity

scientific article

Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.

scientific article published on 20 November 2013

Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production

scientific article published on 10 June 2009

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

scientific article

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

scientific article

High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression

scientific article published on 14 January 2019

Homeostasis and function of regulatory T cells in aging

scientific article

IFN-gamma and self-absorbed CD4+ T cells: a regulatory double negative.

scientific article published in November 2008

IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

scientific article published on 29 July 2020

IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome

scientific article

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

scientific article published on 24 June 2013

IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

scientific article

Immune responses to coiled coil supramolecular biomaterials.

scientific article

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

scientific article published on 9 October 2014

Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

scientific article

It's hard to get downstream without a raft: A commentary on “Reactive oxygen species promote raft formation in T lymphocytes”

scientific article published on 08 January 2007

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice

scientific article

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses ⬇️

scientific article published on April 5, 2013

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

scientific article published on 15 February 2013

Molecular mechanisms of activated T cell death in vivo

scientific article

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

scientific article published on 6 March 2008

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.

scientific article published on 14 April 2008

Nonredundant roles for B cell-derived IL-10 in immune counter-regulation

scientific article published on 20 July 2009

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

scientific article published on 6 February 2004

Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity

scientific article

Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development ⬇️

scientific article published on January 23, 2013

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

scientific article published on 01 October 2019

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

scientific article published on 25 June 2008

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

article

Regulation of T-cell apoptosis by reactive oxygen species.

scientific article published on June 2004

Regulation of cell death in the lymphoid system by Bcl-2 family proteins.

scientific article published on January 2004

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

scientific journal article

RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling

scientific article

Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.

scientific article published on September 2006

STAT5 is critical to maintain effector CD8+ T cell responses.

scientific article

Sensitization of T cells to apoptosis--a role for ROS?

scientific article published in September 2004

T cell apoptosis and reactive oxygen species

scientific article

T cells are potent early mediators of the host response to sepsis.

scientific article published on October 2010

T-cell activation differentially mediates the host response to sepsis

scientific article published in October 2010

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

scientific article published on 26 September 2019

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

scientific article published on 16 November 2016

The immune cell landscape in kidneys of patients with lupus nephritis

scientific article published on 17 June 2019

Tissue-specific control of latent CMV reactivation by regulatory T cells

scientific article published on 10 August 2017

Vaccination protects beta 2 microglobulin deficient mice from immune mediated mortality but not from persisting viral infection

scientific article published on 01 September 1996

List of works by David Hildeman

A major role for Bim in regulatory T cell homeostasis.

A prospective, iterative, adaptive trial of carfilzomib-based desensitization

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

Activation changes the spectrum but not the diversity of genes expressed by T cells.

An adenoviral vector for probing promoter activity in primary immune cells

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

Apoptosis and the homeostatic control of immune responses

Assessment of CD4+ and CD8+ T Cell Responses Using MHC Class I and II Tetramers ⬇️

Bax does not have to adopt its final form to drive T cell death

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

C5a negatively regulates toll-like receptor 4-induced immune responses

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?

Control of Bcl-2 expression by reactive oxygen species

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.

Dying to protect: cell death and the control of T-cell homeostasis.

Eliminating encephalitogenic T cells without undermining protective immunity

Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.

Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression

Homeostasis and function of regulatory T cells in aging

IFN-gamma and self-absorbed CD4+ T cells: a regulatory double negative.

IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Immune responses to coiled coil supramolecular biomaterials.

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

It's hard to get downstream without a raft: A commentary on “Reactive oxygen species promote raft formation in T lymphocytes”

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses ⬇️

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Molecular mechanisms of activated T cell death in vivo

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.

Nonredundant roles for B cell-derived IL-10 in immune counter-regulation

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity

Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development ⬇️

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

Regulation of T-cell apoptosis by reactive oxygen species.

Regulation of cell death in the lymphoid system by Bcl-2 family proteins.

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling

Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.

STAT5 is critical to maintain effector CD8+ T cell responses.

Sensitization of T cells to apoptosis--a role for ROS?

T cell apoptosis and reactive oxygen species

T cells are potent early mediators of the host response to sepsis.

T-cell activation differentially mediates the host response to sepsis

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

The immune cell landscape in kidneys of patients with lupus nephritis

Tissue-specific control of latent CMV reactivation by regulatory T cells

Vaccination protects beta 2 microglobulin deficient mice from immune mediated mortality but not from persisting viral infection