List of works - Kenneth Bernstein

A cDNA sequence encoding a rabbit heavy chain variable region of the VHa2 allotype showing homologies with human heavy chain sequences

scientific article published in November 1982

A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn

scientific article (publication date: 12 November 1999)

A deeply recessed active site in angiotensin-converting enzyme is indicated from the binding characteristics of biotin-spacer-inhibitor reagents

article

A functional Jak2 tyrosine kinase domain is essential for mouse development.

scientific article published on 16 May 2006

A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme

scientific article

A recombinant rat vascular AT1 receptor confers growth properties to angiotensin II in Chinese hamster ovary cells

scientific article published on September 30, 1992

ACE and ACE2 activity in diabetic mice.

scientific article

ACE knockout mice - lessons for adult nephrology

scientific article published on 01 December 1998

ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer's disease

scientific article

ANG II-induced tyrosine phosphorylation stimulates phospholipase C-gamma 1 and Cl-channels in mesangial cells

scientific article published on 01 June 1996

Angiotensin II Activates pp60 c- src in Vascular Smooth Muscle Cells

scientific article published on 01 December 1995

Angiotensin II Controls p21 Activity via pp60

scientific article published in Journal of Biological Chemistry

Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

scientific article published in Journal of Biological Chemistry

Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells

scientific article published in Journal of Biological Chemistry

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension

scientific article published on 29 April 2015

Angiotensin II signal transduction pathways

scientific article published on 01 November 1998

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells

scientific article published in Journal of Biological Chemistry

Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury

scientific article

Angiotensin-converting enzyme is required for normal myelopoiesis

scientific article

Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

scientific article

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline

scientific article

Aortic and renal regulation of the renin-angiotensin system in interrenal aortic coarctation

scientific article published on 01 January 1993

BULLET: a computer simulation of shotgun DNA sequencing.

scientific article published in April 1995

Bovine angiotensin converting enzyme cDNA cloning and regulation. Increased expression during endothelial cell growth arrest

scientific article published on 01 June 1992

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli

scientific article published on 17 March 2016

Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation.

scientific article

Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals

scientific article published in December 1994

Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation

scientific article

DC isoketal-modified proteins activate T cells and promote hypertension.

scientific article

Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor

scientific journal article

Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides

scientific article published on 23 February 2004

Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE).

scientific article

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

scientific article

EHRs can boost compliance

scientific article published on 01 May 2007

Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice

scientific article published on 9 February 2004

Electroporation of pp60c−srcAntibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

scientific article published in Journal of Biological Chemistry

Establishing the role of angiotensin-converting enzyme in renal function and blood pressure control through the analysis of genetically modified mice

scientific article

Evolutionary conservation of splice sites in sterile C mu transcripts and of immunoglobulin heavy chain (IgH) enhancer region sequences

scientific article published in October 1989

Examining the renin-angiotensin system one hundred years after its discovery

scientific article published on 01 January 1998

Expression of nonmuscle myosin heavy chain-B isoform in the vessel wall of porcine coronary arteries after balloon angioplasty.

scientific article

Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP responsive element.

scientific article published in November 1997

Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.

scientific article

Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice

scientific article published in July 2007

Genetic manipulation of the renin-angiotensin system

scientific article published on 01 July 2001

Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo

scientific article

Germline VH genes in an a3 rabbit not typical of any one VHa allotype.

scientific article

Glucocorticoids Induce Angiotensin-Converting Enzyme Expression in Vascular Smooth Muscle

article

Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry.

scientific article

Identification of two positive transcriptional elements within the 91-base pair promoter for mouse testis angiotensin converting enzyme (testis ACE)

scientific article published on 01 January 1995

Immune activation caused by vascular oxidation promotes fibrosis and hypertension

scientific article

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

scientific article

Immunohistochemical localization of rat angiotensin II AT1 receptor

scientific article published on 01 June 1993

Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins

scientific article published in September 2002

Importance of tyrosine phosphorylation in angiotensin II type 1 receptor signaling.

scientific article published on March 1996

Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity

scientific article published on 27 December 2011

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

scientific article published on November 2011

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43.

scientific article

Insights derived from ACE knockout mice

scientific article published on 01 June 2000

Insulin-like growth factor I gene expression in vascular cells.

scientific article published in May 1991

Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion

scientific article

Is angiotensin II a direct mediator of left ventricular hypertrophy? Time for another look

scientific article published on 23 April 2007

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

scientific article published in May 1991

Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor

scientific article published in Journal of Biological Chemistry

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling

scientific article published on 14 August 2003

Kappa-chain allotypes and isotypes in the rabbit: cDNA sequences of clones encoding b9 suggest an evolutionary pathway and possible role of the interdomain disulfide bond in quantitative allotype expression

scientific article

Male fertility is dependent on dipeptidase activity of testis ACE.

scientific article published in November 2005

Mast Cells: The Missing Source of Cardiac Renin?

scientific article published on 01 February 2005

Mice Lacking Endothelial ACE

scientific article published on 01 February 2003

Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure

scientific article published on 01 January 2002

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

scientific article published in May 1996

Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.

scientific article

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.

scientific article published in June 2007

Microglia participate in neurogenic regulation of hypertension

scientific article published on 8 June 2015

Micropuncture determination of nephron function in mice without tissue angiotensin-converting enzyme

scientific article published on 19 October 2004

Modulation of cardiac Ca2+ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes.

scientific article published on 13 January 2004

Molecular analysis of the renin-angiotensin system

scientific article published on November 1, 1992

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

scientific article

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension

scientific article

New insights into the cellular signaling of seven transmembrane receptors: the role of tyrosine phosphorylation.

scientific article published on January 1998

Newer approaches to genetic modeling in mice: tissue-specific protein expression as studied using angiotensin-converting enzyme (ACE).

scientific article

Newly recognized physiologic and pathophysiologic actions of the angiotensin-converting enzyme

scientific article published on April 2004

Nodular (pseudosarcomatous) fasciitis, a nonrecurrent lesion: clinicopathologic study of 134 cases.

scientific article published on April 1982

Nontraditional roles of angiotensin-converting enzyme

scientific article published on 21 February 2012

Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype

scientific article published in January 1983

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

scientific article

Partial protein sequence of mouse and bovine kidney angiotensin converting enzyme

scientific article published on 01 March 1988

Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing

scientific article

Promoter sequences of murine alpha A crystallin, murine alpha 2(I) collagen or of avian sarcoma virus genes linked to the bacterial chloramphenicol acetyl transferase gene direct tissue-specific patterns of chloramphenicol acetyl transferase express

scientific article

Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme

scientific article

Regulated Expression of Testis Angiotensin-Converting Enzyme during Spermatogenesis in Mice1

scientific article published on 01 June 1993

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme

scientific article published on 14 August 2006

Renal angiotensin-converting enzyme and blood pressure control

scientific article

Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition

scientific article

Renal generation of angiotensin II and the pathogenesis of hypertension

scientific article

Role of bradykinin in angiotensin-converting enzyme knockout mice.

scientific article

Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme

scientific article published on 6 July 2015

Sequence of a cDNA encoding Basilea kappa light chains (K2 isotype) suggests a possible relationship of protein structure to limited expression

scientific article

Sequence of a cDNA encoding dog insulin-like growth factor I.

scientific article

Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice

scientific article

Sperm-specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91-base-pair promoter containing a CRE-like element

scientific article published on January 1993

Targeting bacteriophage T7 RNA polymerase to the mammalian cell nucleus

scientific article published in September 1988

Targeting genes for self-excision in the germ line

scientific article

The Angiotensin II AT1 Receptor Is Tyrosine and Serine Phosphorylated and can Serve as a Substrate for the SRC Family of Tyrosine Kinases

scientific article published on 01 April 1994

The Angiotensin II–Dependent Association of Jak2 and c-Src Requires the N-Terminus of Jak2 and the SH2 Domain of c-Src

scientific article published on 01 June 1999

The Importance of Tyrosine Phosphorylation in Angiotensin II Signaling

scientific article

The M694V mutation in Armenian-Americans: a 10-year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA.

scientific article published on 7 November 2012

The Renin-Angiotensin System: A Biological Machine ⬇️

scientific article published on April 1, 1992

The Role of Angiotensin-Converting Enzyme in Blood Pressure Control, Renal Function, and Male Fertility

scientific article published on 01 July 1997

The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.

scientific article

The biology of angiotensin II receptors.

scientific article

The carboxypeptidase ACE shapes the MHC class I peptide repertoire

scientific article

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice

scientific article published on May 1997

The distribution of cadmium-115m chloride, cobalt-57 bleomycin, iodine-125 human serum albumin, selenium-75 selenite and selenomethionine-75 in a rat hepatoma model ⬇️

scientific article published on January 1, 1978

The functional role of angiotensin-converting enzyme as explored by using knockout mice

scientific article published on 01 January 1998

The genomic organization of the rat AT1 angiotensin receptor

scientific journal article

The intrarenal generation of angiotensin II is required for experimental hypertension

scientific article

The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis

scientific article

The role of Ca2+ mobilization and heterotrimeric G protein activation in mediating tyrosine phosphorylation signaling patterns in vascular smooth muscle cells

article

The role of tissue angiotensin-converting enzyme (ACE): studies of ACE mutant mice

scientific article published on 01 November 1998

The role of tyrosine phosphorylation in angiotensin II mediated intracellular signaling and cell growth.

scientific article published on February 1996

The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions.

scientific article published on October 1983

The structural and genetic basis for expression of normal and latent VHa allotypes of the rabbit ⬇️

scientific article published on November 1, 1984

The use of knockout mouse technology to achieve tissue selective expression of angiotensin converting enzyme

scientific article published on June 2004

Tissue Specific Expression of Testis Angiotensin Converting Enzyme is Not Determined by the −32 Nonconsensus TATA Motif

scientific article published on 01 June 1996

Tissue specific expression of angiotensin converting enzyme

scientific article published on January 1, 1992

Tissue specific expression of angiotensin converting enzyme: a new way to study an old friend

scientific article

Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene

scientific article

Transgenic mice demonstrate a testis-specific promoter for angiotensin-converting enzyme

scientific article

Two ACEs and a heart.

scientific article published in June 2002

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

scientific article

Views of the renin-angiotensin system: brilling, mimsy, and slithy tove

scientific article

cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.

scientific article published on October 1996

List of works by Kenneth Bernstein

A cDNA sequence encoding a rabbit heavy chain variable region of the VHa2 allotype showing homologies with human heavy chain sequences

A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn

A deeply recessed active site in angiotensin-converting enzyme is indicated from the binding characteristics of biotin-spacer-inhibitor reagents

A functional Jak2 tyrosine kinase domain is essential for mouse development.

A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme

A recombinant rat vascular AT1 receptor confers growth properties to angiotensin II in Chinese hamster ovary cells

ACE and ACE2 activity in diabetic mice.

ACE knockout mice - lessons for adult nephrology

ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer's disease

ANG II-induced tyrosine phosphorylation stimulates phospholipase C-gamma 1 and Cl-channels in mesangial cells

Angiotensin II Activates pp60 c- src in Vascular Smooth Muscle Cells

Angiotensin II Controls p21 Activity via pp60

Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension

Angiotensin II signal transduction pathways

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells

Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury

Angiotensin-converting enzyme is required for normal myelopoiesis

Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline

Aortic and renal regulation of the renin-angiotensin system in interrenal aortic coarctation

BULLET: a computer simulation of shotgun DNA sequencing.

Bovine angiotensin converting enzyme cDNA cloning and regulation. Increased expression during endothelial cell growth arrest

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli

Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation.

Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals

Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation

DC isoketal-modified proteins activate T cells and promote hypertension.

Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor

Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides

Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE).

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

EHRs can boost compliance

Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice

Electroporation of pp60c−srcAntibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

Establishing the role of angiotensin-converting enzyme in renal function and blood pressure control through the analysis of genetically modified mice

Evolutionary conservation of splice sites in sterile C mu transcripts and of immunoglobulin heavy chain (IgH) enhancer region sequences

Examining the renin-angiotensin system one hundred years after its discovery

Expression of nonmuscle myosin heavy chain-B isoform in the vessel wall of porcine coronary arteries after balloon angioplasty.

Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP responsive element.

Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.

Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice

Genetic manipulation of the renin-angiotensin system

Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo

Germline VH genes in an a3 rabbit not typical of any one VHa allotype.

Glucocorticoids Induce Angiotensin-Converting Enzyme Expression in Vascular Smooth Muscle

Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry.

Identification of two positive transcriptional elements within the 91-base pair promoter for mouse testis angiotensin converting enzyme (testis ACE)

Immune activation caused by vascular oxidation promotes fibrosis and hypertension

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Immunohistochemical localization of rat angiotensin II AT1 receptor

Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins

Importance of tyrosine phosphorylation in angiotensin II type 1 receptor signaling.

Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43.

Insights derived from ACE knockout mice

Insulin-like growth factor I gene expression in vascular cells.

Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion

Is angiotensin II a direct mediator of left ventricular hypertrophy? Time for another look

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling

Kappa-chain allotypes and isotypes in the rabbit: cDNA sequences of clones encoding b9 suggest an evolutionary pathway and possible role of the interdomain disulfide bond in quantitative allotype expression

Male fertility is dependent on dipeptidase activity of testis ACE.

Mast Cells: The Missing Source of Cardiac Renin?

Mice Lacking Endothelial ACE

Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.

Microglia participate in neurogenic regulation of hypertension

Micropuncture determination of nephron function in mice without tissue angiotensin-converting enzyme

Modulation of cardiac Ca2+ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes.

Molecular analysis of the renin-angiotensin system

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension

New insights into the cellular signaling of seven transmembrane receptors: the role of tyrosine phosphorylation.