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List of works by Jiří Klimeš

A model of natural degradation of 17-α-ethinylestradiol in surface water and identification of degradation products by GC-MS.

scientific article published on 22 August 2017

An innovative approach to the analysis of 3-[4-(2-methylpropyl)phenyl]propanoic acid as an impurity of ibuprofen on a carbon-coated zirconia stationary phase.

scientific article published on 24 February 2009

Combination of molecular modeling and quantitative structure-activity relationship analysis in the study of antimycobacterial activity of pyridine derivatives

scientific article published in October 2000

Comparison of different stationary phases for bioanalytical studies of biologically active compounds

scientific article published in September 2006

Determination of ibuprofen in erythrocytes and plasma by high performance liquid chromatography

scientific article published on 01 June 1995

Determination of lipophilicity of novel potential antituberculotic agents using HPLC on monolithic stationary phase and theoretical calculations

scientific article published on 04 January 2008

Development and validation of HPLC-DAD methods for the analysis of two novel iron chelators with potent anti-cancer activity

scientific article published on 12 December 2006

Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium

scientific article published on 28 December 2012

Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.

scientific article published on 2 February 2010

Development of high-performance liquid chromatographic determination of salicylaldehyde isonicotinoyl hydrazone in rabbit plasma and application of this method to an in vivo study

scientific article published in August 2005

Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro.

scientific article published on 20 August 2015

Disposition study of a new potential antineoplastic agent dimefluron in rats using high-performance liquid chromatography with ultraviolet and mass spectrometric detection.

scientific article published in April 2005

HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study.

scientific article

HPLC evaluation of diclofenac in transdermal therapeutic preparations

scientific article published in April 2001

HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents

scientific article

HPLC study of glimepiride under hydrolytic stress conditions

scientific article published in September 2004

HPLC study on stability of pyridoxal isonicotinoyl hydrazone.

scientific article published on 2 August 2005

HPLC-DAD and MS/MS analysis of novel drug candidates from the group of aromatic hydrazones revealing the presence of geometric isomers

scientific article published on 23 December 2007

High-performance liquid chromatographic assay for ibuprofen in whole blood using solid-phase extraction

scientific article published on 01 April 1994

High-performance liquid chromatographic determination of terguride in solid dosage forms and plasma

scientific article published on 01 January 1995

High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples

scientific article

Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.

scientific article published on 27 November 2010

Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography–quadrupole-time-of-flight mass spectrometry

scientific article published on 22 November 2012

Investigation of the stability of aromatic hydrazones in plasma and related biological material.

scientific article

LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.

scientific article published on 17 February 2012

LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

scientific article

Microcolumn high-performance liquid chromatographic assay for doxycycline in isolated alveolar macrophages

scientific article published on 01 June 1999

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1)

scientific article (publication date: 2013)

Optimization of HPLC chromatographic conditions for determination of Transkarbam 12 and its degradation products

scientific article published on 22 May 2006

Photochemical stability of nimesulide.

scientific article

Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).

scientific article

Potential employment of non-silica-based stationary phases in pharmaceutical analysis

scientific article published on 25 April 2007

Preliminary pharmaceutico-analytical evaluation of transkarbam 12 using liquid chromatography

scientific article published on 01 July 2006

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

scientific article published on 20 November 2013

Stability of ramipril in the solvents of different pH.

scientific article published in April 2005

The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase

scientific article published on 27 December 2011

The retention behaviour of polar compounds on zirconia based stationary phases under hydrophilic interaction liquid chromatography conditions

scientific article published on 06 August 2011

Titania-based stationary phase in separation of ondansetron and its related compounds.

scientific article

Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species.

scientific article published on 28 November 2004

Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms

scientific article published on 13 May 2011

Use of the zirconia-based stationary phase for separation of ibuprofen and its impurities

scientific article published on 17 March 2005

Using of HPLC coupled with coulometric detector for the determination of biotin in pharmaceuticals.

scientific article published on 15 August 2007

Utilization of zirconia stationary phase as a tool in drug control.

scientific article published in August 2005

Zirconia--a stationary phase capable of the separation of polar markers of myocardial metabolism in hydrophilic interaction chromatography

scientific article published on 31 March 2014

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