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List of works by Po Sing Leung

A local pancreatic renin-angiotensin system: endocrine and exocrine roles

scientific article

A locally generated angiotensin system in rat carotid body.

scientific article

A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets

scientific article published on 20 March 2011

AT1 receptor antagonism ameliorates acute pancreatitis-associated pulmonary injury

scientific article published on 27 January 2006

Activation of an Adenosine 3′,5′-Cyclic Monophosphate-Dependent Cl− Conductance in Response to Neurohormonal Stimuli in Mouse Endometrial Epithelial Cells: The Role of Cystic Fibrosis Transmembrane Conductance Regulator1

scientific article published on 01 February 1999

Acute pancreatitis: animal models and recent advances in basic research

scientific article published on January 2007

Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide

scientific article published on 01 January 1999

An update on the islet renin-angiotensin system

scientific article published on 17 March 2011

Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymis

scientific article published in January 2002

Angiotensin II Receptor Type I-Regulated Anion Secretion in Cystic Fibrosis Pancreatic Duct Cells

scientific article published on 01 April 1997

Angiotensin II Type 1 Receptor Antagonism Mediates Uncoupling Protein 2-Driven Oxidative Stress and Ameliorates Pancreatic Islet β-Cell Function in Young Type 2 Diabetic Mice

scientific article published on 01 July 2007

Angiotensin II Type 1 Receptor-Dependent Nuclear Factor- B Activation-Mediated Proinflammatory Actions in a Rat Model of Obstructive Acute Pancreatitis

scientific article published on 06 July 2007

Angiotensin II Type 2 Receptor Activation With Compound 21 Augments Islet Function and Regeneration in Streptozotocin-Induced Neonatal Rats and Human Pancreatic Progenitor Cells

scientific article published on 18 January 2017

Angiotensin II Type 2 Receptor Is Critical for the Development of Human Fetal Pancreatic Progenitor Cells into Islet‐like Cell Clusters and Their Potential for Transplantation ⬇️

scientific article published on March 1, 2012

Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors

scientific article published on 4 November 2009

Angiotensin II receptors, AT1 and AT2 in the rat epididymis

scientific article published on 01 June 1997

Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes

scientific article published in February 2006

Angiotensin II type 1 receptor inhibition markedly improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascularised syngeneic mouse islet grafts

scientific article published on 5 May 2005

Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos

scientific article published on 23 November 2013

Angiotensinogen expression by rat epididymis: evidence for an intrinsic, angiotensin-generating system

article

Asian-Oceanic Pancreatic Association: conception to actuality

scientific article published in November 2005

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Basic techniques for pancreatic research

scientific article published on January 2010

Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines

scientific article

Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway.

scientific article published on 22 December 2017

Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase.

scientific article

Bruceines K and L from the Ripe Fruits of Brucea javanica

Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus

scientific article

Cells of the anterior pituitary.

scientific article

Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis

scientific article published in June 2003

Chronic hypoxia activates a local angiotensin-generating system in rat carotid body.

scientific article

Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expression

scientific article published on 09 October 2001

Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis

scientific article published on 01 January 2001

Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body

scientific journal article

Circulating RAS.

scientific article published on January 2010

Co-operative effects of angiotensin II and caerulein in NFκB activation in pancreatic acinar cells in vitro

scientific article published on 17 October 2010

Combination of Telmisartan and Linagliptin Preserves Pancreatic Islet Cell Function and Morphology in db/db Mice

scientific article published on 22 October 2015

Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]m

scientific article

Common pancreatic disease

scientific article published on January 2010

Current research concerning the RAS in pancreatic stem cells

scientific article published on January 2010

Current research of the RAS in diabetes mellitus

scientific article published on January 2010

Current research of the RAS in pancreatitis and pancreatic cancer

scientific article published on January 2010

DIFFERENTIAL GENE EXPRESSION OF ANGIOTENSIN II RECEPTOR SUBTYPES IN THE EPIDIDYMIDES OF MATURE AND IMMATURE RATS

article

Desoxyrhaponticin (3,5-Dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies

scientific article published on 12 October 2006

Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane.

scientific article

Diarylheptanoids and a monoterpenoid from the rhizomes of Zingiber officinale: antioxidant and cytoprotective properties

scientific article published on 5 January 2008

Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis

scientific article (publication date: 28 March 2003)

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

scientific article

Does vitamin D supplementation reduce type 2 diabetes risk?

scientific article published on 01 November 2019

EFFECT OF ANGIOTENSIN AT1RECEPTOR ANTAGONIST ON d-GALACTOSAMINE-INDUCED ACUTE LIVER INJURY

scientific article published on 01 October 2007

Effect of chronic hypoxia on glutathione status and membrane integrity in the pancreas

scientific article

Enantiospecific Synthesis of Pseudoacarviosin as a Potential Antidiabetic Agent

scientific article published on 17 June 2008

Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters

scientific article published on 07 September 2020

Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways

scientific article published on 26 April 2012

Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets

scientific article

Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies

scientific article published on 10 May 2017

Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response

scientific article published in November 2003

Expression and localization of the renin-angiotensin system in the rat pancreas

scientific article published on 01 January 1999

Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP.

scientific article published in November 1998

Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese

scientific article published on 20 January 2014

Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus

scientific article published on 31 March 2016

Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling.

scientific article

Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism

scientific article published on 01 October 2019

Frontiers in diabetic research

scientific article published on 02 February 2006

Functional expression of angiotensin II receptors in type-I cells of the rat carotid body.

scientific article

Functional expression of sperm angiotensin II type I receptor in Xenopus oocyte: modulation of a sperm Ca2+-activated K+ channel

scientific article published in December 1998

GPR120 is an important inflammatory regulator in the development of osteoarthritis

article

GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation

scientific article published on 11 January 2019

Ghrelin system in pancreatic AR42J cells: its ligand stimulation evokes calcium signalling through ghrelin receptors.

scientific article published on April 2005

Hedgehog signaling in bone regulates whole-body energy metabolism through a bone-adipose endocrine relay mediated by PTHrP and adiponectin.

scientific article published on 14 October 2016

High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling

scientific article published on 29 July 2013

High prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas

scientific article published on 01 December 2002

Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters ⬇️

scientific article published on 21 August 2019

Human fetal liver stromal cell co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters.

scientific article published in April 2014

IL-1β inhibits β-Klotho expression and FGF19 signaling in hepatocytes

scientific article published on 15 December 2015

Identification and Functional Implications of Sodium/Myo-Inositol Cotransporter 1 in Pancreatic β-Cells and Type 2 Diabetes

scientific article published on 15 February 2017

Immunochemical characterisation of tachykinin immunoreactivity in the nervous system of the garden snail, Helix aspersa

scientific article published in September 1992

Immunocytochemical distribution of neuropeptide F (NPF) in the gastropod mollusc, Helix aspersa, and in several other invertebrates

scientific article published on 01 February 1994

Immunocytochemical localization of neuropeptide F-Immunoreactivity in the circumoesophageal ganglia of the gastropod mollusc, Helix aspersa using electron microscopy

scientific article published on 01 February 1994

Immunohistochemical localization of angiotensin II in the mouse pancreas

scientific article published on 01 January 1998

In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice

scientific article published on 7 September 2005

Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin.

scientific article

Inhibition of the sodium glucose co-transporter-2: its beneficial action and potential combination therapy for type 2 diabetes mellitus

scientific article published on 06 February 2013

Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states

scientific article published on 15 December 2016

Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane

Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells

scientific article

Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice

scientific article

Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells

scientific article

Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions

scientific article published on 22 November 2018

Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling

scientific article published on 21 July 2016

Local RAS.

scientific article published on January 2010

Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells.

scientific article

Local regulation of epididymal anion secretion by pituitary adenylate cyclase-activating polypeptide

scientific article published on 01 September 1997

Localization and distribution of pituitary adenylate cyclase-activating polypeptide in the rat epididymis.

scientific article

Localization of angiotensin II receptor subtypes AT1 and AT2 in the pancreas of rodents.

scientific article published on May 1997

Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice

scientific article

Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes.

scientific article published on February 2007

Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells

scientific article published on 19 October 2006

Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice.

scientific article published on 19 December 2012

Multifaceted interplay among mediators and regulators of intestinal glucose absorption: potential impacts on diabetes research and treatment

scientific article

NADPH Oxidase-Dependent Reactive Oxygen Species Stimulate β-Cell Regeneration Through Differentiation of Endocrine Progenitors in Murine Pancreas

scientific article published on 14 October 2015

Na+ /H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of sodium-glucose co-transporter 1-mediated glucose absorption in the small intestine

scientific article published on 7 November 2017

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets

scientific article

No evidence for a local renin-angiotensin system in liver mitochondria

scientific journal article

Novel roles of a local angiotensin-generating system in the carotid body

Overview of the pancreas

scientific article published on January 2010

PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization

scientific article published on September 2009

PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells.

scientific article published on 24 October 2007

PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease

scientific article (publication date: June 2007)

Pancreatic Cancer, Pancreatitis, and Oxidative Stress

Pancreatic RAS.

scientific article published on January 2010

Pancreatic acinar cell: its role in acute pancreatitis

scientific article

Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus

scientific article

Physiology of the pancreas

scientific article published on January 2010

Potential roles of GPR120 and its agonists in the management of diabetes

scientific article

Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis

scientific article

Quantitation and chromatographic characterisation of neuropeptide F(NPF) immunoreactivity in molluscan nervous tissue using region-specific antisera

scientific article

Reduced immunogenicity of pancreatic progenitor cells derived from first-trimester human fetal pancreas ⬇️

scientific article published on February 23, 2011

Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis

scientific article published on 01 August 2000

Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours

scientific article published on 01 April 2002

Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat.

scientific article

Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body

scientific journal article

Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium.

scientific article

Renin-angiotensin system in the carotid body.

scientific article

Renin–angiotensin systems: the new frontier

scientific article published in 2003

Revisiting the use of biological fluids for noninvasive glucose detection

scientific article published on 17 March 2020

Rod-type cyclic nucleotide-gated cation channel is expressed in vascular endothelium and vascular smooth muscle cells

scientific article published on 01 January 1999

Role of oxidative stress in pancreatic inflammation

scientific article published on January 2009

Roles of the renin–angiotensin system and its blockade in pancreatic inflammation

scientific article published on 01 January 2005

SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation

scientific article published on 22 August 2019

Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis

scientific article (publication date: April 2003)

Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells

scientific article

Seven Quassinoids from Fructus Bruceae with Cytotoxic Effects on Pancreatic Adenocarcinoma Cell Lines ⬇️

scientific article published on April 8, 2011

Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency

scientific article

Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis

scientific article published on 01 February 2000

The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos

scientific article published on June 2015

The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes

scientific article published on 25 January 2016

The Modulatory Action of Vitamin D on the Renin-Angiotensin System and the Determination of Hepatic Insulin Resistance

scientific article published on 05 July 2019

The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus

scientific article

The Renin-Angiotensin System: Current Research Progress in The Pancreas

The Renin-angiotensin system and reactive oxygen species: implications in pancreatitis

scientific article published on 15 September 2011

The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function

scientific article published on January 2010

The peptide hormone angiotensin II: its new functions in tissues and organs

scientific article published in August 2004

The physiology of a local renin-angiotensin system in the pancreas

scientific article published on 11 January 2007

The potential of irisin as a therapeutic for diabetes

scientific article published on 12 April 2017

The primary structure of neuropeptide F (NPF) from the garden snail, Helix aspersa

scientific article published on 01 September 1992

The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition

scientific article published in December 2003

The renin-angiotensin system and male reproduction: new functions for old hormones.

scientific article

The role of renin-angiotensin system in cellular differentiation: implications in pancreatic islet cell development and islet transplantation

scientific article published on 28 August 2013

The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis.

scientific article published in July 2004

Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport.

scientific article

Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia

scientific journal article

Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer

scientific article published on 27 May 2014

Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas

scientific article published in March 2011

“Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism”: Might Reduced Vitamin D Availability Due to Increases in Maternal Body Fat Contribute to This Effect?

scientific article published on 30 July 2015

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