List of works by Alejandro Villarino

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

scientific article

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

scientific article

An autoregulatory enhancer controls mammary-specific STAT5 functions.

scientific article published on 7 October 2015

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

scientific article

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

scientific article published on 22 May 2017

Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27

scientific article

Cell cycle controlling the silencing and functioning of mammalian activators

scientific article published in October 2001

Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene.

scientific article published in March 2001

Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.

scientific article published in April 2004

Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells

scientific article

Distinct requirements for T-bet in gut innate lymphoid cells

scientific article

Duration of antigen receptor signaling determines T-cell tolerance or activation

scientific article

Extraordinary effects of unnatural pairings

scientific article

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

scientific article

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

scientific article

IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens

scientific article published on 27 July 2012

IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis

scientific article published on 01 April 2020

IL-27 limits IL-2 production during Th1 differentiation.

scientific article published on January 2006

IL-27 shakes up the establishment of ectopic lymphoid structures

scientific article

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

scientific article published on 28 March 2008

Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells

scientific article

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells

scientific article published on 01 September 2019

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

scientific article published on 13 August 2006

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

scientific article published on 6 November 2017

Mechanisms and consequences of Jak-STAT signaling in the immune system.

scientific article published on March 2017

Mechanisms of Jak/STAT signaling in immunity and disease

scientific article published in January 2015

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

article

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

scientific article published in June 2005

Posttranscriptional control of T cell effector function by aerobic glycolysis

scientific article

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

scientific article

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

scientific article published in June 2001

STAT1-Activating Cytokines Limit Th17 Responses through Both T-bet–Dependent and –Independent Mechanisms ⬇️

scientific article published on October 25, 2010

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.

scientific article published on 29 November 2017

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

scientific article published on 21 March 2016

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells

scientific article published on 15 September 2017

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

scientific article published on 4 February 2013

TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.

scientific article published in January 2005

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

scientific article published on 01 November 2004

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection

scientific article published in November 2003

The JAK-STAT pathway: impact on human disease and therapeutic intervention

scientific article

The role of IL-27 in the development of T-cell responses during parasitic infections

scientific article

Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

scientific article

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