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List of works by Saskia Nijmeijer

7TM Domain Structure of Adhesion GPCRs

scientific article published on January 2016

A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation

scientific article published on 16 November 2010

Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms

scientific article

Adhesion GPCRs in immunology

scientific article published on 27 April 2016

Analysis of multiple histamine H₄ receptor compound classes uncovers Gαi protein- and β-arrestin2-biased ligands

scientific article published on 12 September 2012

Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode

scientific article

Classification, Nomenclature, and Structural Aspects of Adhesion GPCRs

scientific article published on January 2016

Combinatorial Consensus Scoring for Ligand-Based Virtual Fragment Screening: A Comparative Case Study for Serotonin 5-HT(3)A, Histamine H(1), and Histamine H(4) Receptors

scientific article published on 23 April 2015

Constitutive activity of the histamine H(1) receptor

scientific article

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor.

scientific article

Detailed analysis of biased histamine H₄ receptor signalling by JNJ 7777120 analogues

scientific article published on September 2013

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling

scientific article

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

scientific article

G protein-coupled receptors: walking hand-in-hand, talking hand-in-hand?

scientific article published on May 2011

High-resolution metabolic profiling towards G protein-coupled receptors: rapid and comprehensive screening of histamine H₄ receptor ligands.

scientific article

Mapping histamine H4receptor–ligand binding modes

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies

scientific article published on 7 November 2011

Molecular pharmacology of histamine H4 receptors

scientific article published on June 2012

Real-time visualization of heterotrimeric G protein Gq activation in living cells

scientific article

Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28.

scientific article

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics

scientific article

Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor

The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning

scientific article

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines

scientific article

Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4Receptor Affinity and Subtly Govern H4/H3Subtype Selectivity

scientific article published on 24 February 2011

Viral hijacking of human receptors through heterodimerization

scientific article published on 26 September 2008

Virtual Fragment Screening: Discovery of Histamine H3 Receptor Ligands Using Ligand-Based and Protein-Based Molecular Fingerprints

scientific article published on 03 December 2012

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