List of works - Javier Caceres

A novel SR-related protein is required for the second step of Pre-mRNA splicing

scientific article

A novel role for shuttling SR proteins in mRNA translation

scientific article

A rapid and efficient protocol to purify biologically active recombinant proteins from mammalian cells.

scientific article

A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes

article

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm ⬇️

scientific article published on January 1, 1998

An Aptamer Targeting the Apical-Loop Domain Modulates pri-miRNA Processing

scientific article published on 01 June 2010

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.

scientific article published on 18 July 2010

Cellular functions of the microprocessor

scientific article

Cellular stress and RNA splicing

scientific article published on 07 February 2009

Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta.

scientific article published on 24 October 2016

Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT

scientific article published on 20 November 2005

Control of mammalian retrotransposons by cellular RNA processing activities

scientific article

Control of mouse U1a and U1b snRNA gene expression by differential transcription.

scientific article published in August 1992

DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.

scientific article

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

scientific article

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.

scientific article

Division of labor: minor splicing in the cytoplasm

scientific article published in November 2007

Drosha regulates gene expression independently of RNA cleavage function.

scientific article published on 19 December 2013

Editing independent effects of ADARs on the miRNA/siRNA pathways

scientific article

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

scientific article

Genetic variation and RNA structure regulate microRNA biogenesis

scientific article published on 3 May 2017

Hormonal Regulation of MicroRNA Biogenesis

scientific article published on 01 October 2009

Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation.

scientific article

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.

scientific article published on December 2014

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors

scientific article

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum

scientific article published on 02 July 2020

Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF

scientific article

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

scientific article

Mechanism and regulation of the nonsense-mediated decay pathway

scientific article

Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

scientific article published on 16 April 2007

Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans

scientific article published in December 2001

Multiple roles of arginine/serine-rich splicing factors in RNA processing.

scientific article

Multiple roles of the SR protein family in splicing regulation.

scientific article

Nonsense-Mediated mRNA Decay in Caenorhabditis elegans

scientific article published on 01 January 2008

Nuclear export and retention signals in the RS domain of SR proteins

scientific article

Post-transcriptional control of miRNA biogenesis

scientific article published on 17 October 2018

Posttranscriptional regulation of miRNAs harboring conserved terminal loops.

scientific article

Pre-mRNA splicing: life at the centre of the central dogma

scientific article

Proteomic Analysis of SRm160-containing Complexes Reveals a Conserved Association with Cohesin

scientific article published on 13 September 2005

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

scientific article published on 19 May 2022

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

scientific article

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

scientific article published on 18 November 2020

Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors

scientific article (publication date: 16 September 1994)

Requirement of DNA topoisomerases for in vitro chromatin assembly by 3T6 mouse cell extracts

scientific article published on 01 May 1989

Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor.

scientific article

Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing

scientific article

Stressful splicing.

scientific article published in October 2007

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.

scientific article

The Microprocessor controls the activity of mammalian retrotransposons

scientific article (publication date: October 2013)

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex

scientific article published on 15 September 2014

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

scientific article

The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.

scientific article published on 20 October 2016

The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation

scientific article published on 30 June 2016

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.

scientific article

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

scientific article published on 25 February 2020

The dynamics of a pre-mRNA splicing factor in living cells

scientific article (publication date: 29 May 1997)

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

scientific article published on 10 June 2007

The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease.

scientific article published on 13 July 2007

The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.

scientific article

The translational landscape of the splicing factor SRSF1 and its role in mitosis.

scientific article published on 6 May 2014

hnRNP A1 relocalization to the stress granules reflects a role in the stress response.

scientific article

List of works by Javier Caceres

A novel SR-related protein is required for the second step of Pre-mRNA splicing

A novel role for shuttling SR proteins in mRNA translation

A rapid and efficient protocol to purify biologically active recombinant proteins from mammalian cells.

A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm ⬇️

An Aptamer Targeting the Apical-Loop Domain Modulates pri-miRNA Processing

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.

Cellular functions of the microprocessor

Cellular stress and RNA splicing

Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta.

Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT

Control of mammalian retrotransposons by cellular RNA processing activities

Control of mouse U1a and U1b snRNA gene expression by differential transcription.

DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.

Division of labor: minor splicing in the cytoplasm

Drosha regulates gene expression independently of RNA cleavage function.

Editing independent effects of ADARs on the miRNA/siRNA pathways

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

Genetic variation and RNA structure regulate microRNA biogenesis

Hormonal Regulation of MicroRNA Biogenesis

Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation.

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum

Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

Mechanism and regulation of the nonsense-mediated decay pathway

Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans

Multiple roles of arginine/serine-rich splicing factors in RNA processing.

Multiple roles of the SR protein family in splicing regulation.

Nonsense-Mediated mRNA Decay in Caenorhabditis elegans

Nuclear export and retention signals in the RS domain of SR proteins

Post-transcriptional control of miRNA biogenesis

Posttranscriptional regulation of miRNAs harboring conserved terminal loops.

Pre-mRNA splicing: life at the centre of the central dogma

Proteomic Analysis of SRm160-containing Complexes Reveals a Conserved Association with Cohesin

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors

Requirement of DNA topoisomerases for in vitro chromatin assembly by 3T6 mouse cell extracts

Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor.

Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing

Stressful splicing.

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.

The Microprocessor controls the activity of mammalian retrotransposons

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.

The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

The dynamics of a pre-mRNA splicing factor in living cells

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease.

The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.

The translational landscape of the splicing factor SRSF1 and its role in mitosis.

hnRNP A1 relocalization to the stress granules reflects a role in the stress response.