List of works by Akos Heinemann

11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils

scientific article (publication date: 27 February 2004)

5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent chemoattractant for human basophils

scientific article published on 3 October 2005

A Novel Assay to Measure the Calcium Flux in Human Basophils: Effects of Chemokines and Nerve Growth Factor

scientific article published on 4 December 2002

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

scientific article published on 27 May 2012

A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.

scientific article

A biological target for antiplatelet therapy: the prostaglandin E2 receptor EP4.

scientific article published on 16 November 2010

A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst

scientific article published on 21 August 2007

A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils

scientific article

A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function.

scientific article

Acid challenge delays gastric pressure adaptation, blocks gastric emptying and stimulates gastric fluid secretion in the rat

scientific article published in February 2003

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung

scientific article published on 11 January 2016

Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function

scientific article

Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production

scientific article

Adhesion of Eosinophils to Endothelial Cells or Substrates Under Flow Conditions

scientific article published in 2014

Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis

scientific article

Advanced oxidation protein products are antagonists of the HDL receptor SR-BI

scientific article published in 2009

Aging affects high-density lipoprotein composition and function

scientific article

Altered inhibitory function of the E-type prostanoid receptor 4 in eosinophils and monocytes from aspirin-intolerant patients

scientific article published on 17 December 2014

Anti-psoriatic therapy recovers high-density lipoprotein composition and function

scientific article

Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naïve allergic patients and allergen-challenged mice

scientific article published on 10 September 2019

Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling.

scientific article

Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma

scientific article published on April 2013

CCK-evoked hyperemia in rat gastric mucosa involves neural mechanisms and nitric oxide

scientific article published in February 1996

CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation

scientific article published on 14 April 2010

CRTH2 Is Not Involved in the Anti-Enteropooling Effect of PGD 2 in the Small Intestine

scientific article published in 2008

CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases

scientific article published on 16 June 2010

Cannabinoid inhibition of guinea-pig intestinal peristalsis via inhibition of excitatory and activation of inhibitory neural pathways

scientific article published in September 1999

Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice

scientific article published on 06 February 2016

Chemotaxis of bone marrow derived eosinophils in vivo: a novel method to explore receptor-dependent trafficking in the mouse

scientific article published on 14 June 2013

Correction: High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration

scientific article published on 3 June 2016

Cyanate is a novel inducer of endothelial icam-1 expression

scientific article published on 14 October 2011

Cyclooxygenase 2 and lipoxin A₄ in nasal polyps in cystic fibrosis

scientific article published in November 2011

Cyclooxygenase inhibition in human monocytes increases endotoxin-induced TNFα without affecting cyclooxygenase-2 expression

scientific article published in October 2004

Cytokines and their association with insulin resistance in obese pregnant women with different levels of physical activity.

scientific article published on 4 November 2015

D-type prostanoid receptor enhances the signaling of chemoattractant receptor–homologous molecule expressed on TH2 cells

scientific article published in February 2012

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

scientific article published in April 2018

Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis

scientific article published in May 2003

Designing a mutant CCL2-HSA chimera with high glycosaminoglycan-binding affinity and selectivity

scientific article published on 11 May 2015

Determination of sIgE to rPhl p 1 is sufficient to diagnose grass pollen allergy.

scientific article published on 11 October 2013

Dialysis Modalities and HDL Composition and Function

scientific article

Different receptors mediating the inhibitory action of exogenous ATP and endogenously released purines on guinea-pig intestinal peristalsis

scientific article

Differential involvement of Ca2+ and actin filament in leukocyte shape change

scientific article published on 18 December 2008

Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine

scientific article

Differential regulation of mesenteric and femoral blood flow in the rat as revealed by computerized data acquisition and evaluation

scientific article

Differential response of arterial and venous endothelial cells to extracellular matrix is modulated by oxygen

scientific article published in February 2012

Dilatation by angiotensin II of the rat femoral arterial bed in vivo via pressure/flow-induced release of nitric oxide and prostaglandins

scientific article

Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors

scientific article

Divergent effects of propranolol and nadolol in isolated mesenteric arteries from normal and portal hypertensive rats

scientific article published in August 1996

Diverse interactions of calcitonin gene related peptide and nitric oxide in the gastric and cutaneous microcirculation.

scientific article published on July 1995

Double-stranded RNA attenuates the barrier function of human pulmonary artery endothelial cells

scientific article

E-type prostanoid receptor 4 (EP4) in disease and therapy

scientific article

EP4 receptor stimulation down-regulates human eosinophil function.

scientific article

Effect of angiotensin II and telmisartan, an angiotensin1 receptor antagonist, on rat gastric mucosal blood flow.

scientific article published in March 1999

Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2receptors

scientific article published in March 2008

Effect of terlipressin on in vitro vascular hyporeactivity of portal hypertensive rats

scientific article published in June 1996

Effects of PGH2 and PGD2 on CRTH2 and DP receptors in primary cells and co-expressed in HEK293 cells

scientific article published on 5 November 2008

Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking

scientific article

Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells

scientific article

Endothelial prostaglandin I2 restrains eosinophil trafficking

scientific article published on 12 November 2009

Endothelium-derived prostaglandin I(2) controls the migration of eosinophils

scientific article published on 11 February 2010

Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.

scientific article published on 29 February 2016

Erratum to: Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.

scientific article published on 25 May 2013

Erratum: GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

scientific article published in November 2011

Evaluation of peristalsis in multiple segments of the guinea-pig isolated small intestine: optimisation of tissue use by refined in vitro methodology.

scientific article published in September 2003

GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis.

scientific article

GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

scientific article

GPR55: signaling pathways and functions

scientific article published in 2009

Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents

scientific article published in September 1998

Gastric mucosal blood flow regulation in response to different stimuli.

scientific article published in September 1997

Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling

scientific article

Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase

scientific article published on 01 September 2006

High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration

scientific article

Identification of Selective Basophil Chemoattractants in Human Nasal Polyps as Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2

scientific article published on 4 November 2004

Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.

scientific article published on 3 May 2005

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis

scientific article published on 2 May 2011

Inconsistent results of diagnostic tools hamper the differentiation between bee and vespid venom allergy

scientific article

Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils

scientific article published on 29 April 2002

Inflammation alters HDL composition and function: implications for HDL-raising therapies

scientific article published on 14 December 2012

Influence of total IgE levels on the severity of sting reactions in Hymenoptera venom allergy.

scientific article published in August 2007

Inhibition by female sex steroids of peristalsis in the guinea pig small intestine

scientific article published in January 2002

Inhibition of acid-induced hyperaemia in the rat stomach by endogenous NK2 receptor ligands

scientific article published in November 1997

Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells

scientific article published on 3 May 2012

Inhibition of prostaglandin biosynthesis in human endotoxin-stimulated peripheral blood monocytes: effects of caffeine

scientific article

Inhibitory effect of prostaglandin I2 on bone marrow kinetics of eosinophils in the guinea pig

scientific article published on 17 May 2011

Inhibitory effects of prostaglandin EP4 receptors on human eosinophils

scientific article published in 2009

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

scientific article

Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques.

scientific article

Intestinal motor depression by 7-nitroindazole through an action unrelated to nitric oxide synthase inhibition

scientific article published in December 1999

Involvement of mu- and kappa-, but not delta-, opioid receptors in the peristaltic motor depression caused by endogenous and exogenous opioids in the guinea-pig intestine.

scientific article

Lack of effect of a selective vasopressin V1A receptor antagonist SR 49,059, on potentiation by vasopressin of adrenoceptor-mediated pressor responses in the rat mesenteric arterial bed.

scientific article

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation

scientific article

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation

scientific article published in 2012

Liver disease alters high-density lipoprotein composition, metabolism and function

scientific article published on 19 April 2016

Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

scientific article

Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture

scientific article

Mediation by 5_hydroxytryptamine of the femoral vasoconstriction induced by acid challenge of the rat gastric mucosa.

scientific article published in June 1998

Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa.

scientific article published in October 1995

Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: novel pathways generating dysfunctional high-density lipoprotein

scientific article published on 8 May 2012

Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo

scientific article

Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL.

scientific article published on 24 November 2014

Nitric oxide-dependent and -independent hyperaemia due to calcitonin gene-related peptide in the rat stomach.

scientific article

Nitric oxide-dependent and -independent vascular hyporeactivity in mesenteric arteries of portal hypertensive rats

scientific article

O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms

scientific article

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

scientific article

On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment

scientific article

Opposing roles of prostaglandin D2 receptors in ulcerative colitis

scientific article

Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression

scientific article published on 24 February 2016

PGD2 metabolism in plasma: Kinetics and relationship with bioactivity on DP1 and CRTH2 receptors

scientific article published on 30 March 2007

PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2

scientific article (publication date: 2012)

Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils

scientific article published on 27 February 2015

Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption

scientific article published on 16 March 2011

Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo

scientific article

Post-transcriptional down regulation of ICAM-1 in feto-placental endothelium in GDM.

scientific article published on 13 January 2016

Pressor and mesenteric arterial hyporesponsiveness to angiotensin II is an early event in haemorrhagic hypotension in anaesthetised rats

scientific article published in October 1999

Propranolol stereoselectively inhibits alpha-adrenoceptor-mediated vasoconstriction in mesenteric arterial beds of rats

scientific article published in June 1996

Prostaglandin E2 acts via the EP4 receptor to inhibit platelet aggregation.

scientific article published on 12 November 2009

Prostaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors

scientific article

Prostaglandin E2 levels and platelet function are different in cord blood compared to adults

scientific article published on 14 August 2014

Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2.

scientific article published on 3 October 2008

Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury

scientific article published in June 1999

Protein carbamylation renders high-density lipoprotein dysfunctional

scientific article

Protein kinase C-ζ is involved in the inhibition of eosinophil migration.

scientific article

Psoriasis alters HDL composition and cholesterol efflux capacity

scientific article published on 30 May 2012

Restriction of drinking water abrogates splanchnic vasodilation and portal hypertension in portal vein-ligated rats

scientific article

Secretoneurin, a novel neuropeptide, in the human dental pulp

scientific article published in May 1998

Sensory nerves, nitric oxide and NANC vasodilatation.

scientific article published on January 1995

Sequential induction of prostaglandin E and D synthases in inflammation

scientific article (publication date: 30 September 2005)

Signalling and function of the human G protein-coupled receptor 55.

scientific article

Sodium salicylate enhances the expression of cyclooxygenase-2 in endotoxin-stimulated human mononuclear cells

scientific article published in December 2001

Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils

scientific article

Stimulant action of pituitary adenylate cyclase-activating peptide on normal and drug-compromised peristalsis in the guinea-pig intestine

scientific article

Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro

scientific article published in January 1998

Tachykinin inhibition of acid-induced gastric hyperaemia in the rat.

scientific article published in December 1996

Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation.

scientific article published on 29 December 2014

The CD63 basophil activation test in Hymenoptera venom allergy: a prospective study

scientific article published in October 2004

The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro

scientific article published on 24 September 2019

The D-type prostanoid (DP) receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)

scientific article published in 2011

The EP3 Agonist Sulprostone Enhances Platelet Adhesion But Not Thrombus Formation Under Flow Conditions.

scientific article published on 30 July 2015

The GPR55 antagonist CID16020046 protects against intestinal inflammation.

scientific article published on 30 July 2015

The atypical cannabinoid O-1602 shows antitumorigenic effects in colon cancer cells and reduces tumor growth in a colitis-associated colon cancer model

The basophil activation test in the diagnosis of allergy: technical issues and critical factors

scientific article published on 20 February 2009

The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.

scientific article

The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors

scientific article

The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation

scientific article published on 11 November 2010

The pulmonary microvascular endothelial barrier function is controlled by the PGE2-EP4 signaling axis

scientific article published in 2010

The role of CB2 receptor ligands in human eosinophil function

article

The role of PGE2 EP4 receptors in the regulation of endothelial barrier function.

scientific article published on 17 September 2012

The role of inducible nitric oxide synthase in vascular hyporeactivity of endotoxin-treated and portal hypertensive rats.

scientific article

The role of prostacyclin in the interaction of endothelial cells and eosinophil granulocytes

The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking

scientific article

The urea decomposition product cyanate promotes endothelial dysfunction

scientific article published on 18 June 2014

Therapeutic Potential of Hematopoietic Prostaglandin D2 Synthase in Allergic Inflammation

scientific article published on 20 June 2019

Urea induces intercellular adhesion molecule-1 expression

scientific article published on 5 September 2011

Uremia alters HDL composition and cholesterol efflux capacity.

scientific article published on 17 September 2012

Uremia alters HDL composition and function

scientific article

Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain

scientific article published in May 2001

Vascular bed-dependent roles of the peptide CGRP and nitric oxide in acid-evoked hyperaemia of the rat stomach.

scientific article published in November 1994

Vasodilator responses to nitric oxide are enhanced in mesenteric arteries of portal hypertensive rats

scientific article published in September 1996

Vasopressin reverses mesenteric hyperemia and vasoconstrictor hyporesponsiveness in anesthetized portal hypertensive rats

scientific article published in September 1998

Visceral vasodilatation and somatic vasoconstriction evoked by acid challenge of the rat gastric mucosa: diversity of mechanisms.

scientific article published on July 1995

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