List of works - Gunther Marsche

2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis.

scientific article

A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.

scientific article

Abnormal composition and function of high-density lipoproteins in atopic dermatitis patients

scientific article published on 30 October 2018

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung

scientific article published on 11 January 2016

Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function

scientific article

Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo.

scientific article published on 4 May 2018

Adiponectin Predicts High-Density Lipoprotein Cholesterol Efflux Capacity in Adults Irrespective of Body Mass Index and Fat Distribution

scientific article

Advanced oxidation protein products are antagonists of the HDL receptor SR-BI

scientific article published in 2009

Aging affects high-density lipoprotein composition and function

scientific article

Allergic rhinitis is associated with complex alterations in high-density lipoprotein composition and function

scientific article published on 08 June 2019

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System ⬇️

scientific article published on 24 June 2020

Anti-psoriatic therapy recovers high-density lipoprotein composition and function

scientific article

Antipsoriatic treatment extends beyond the skin: recovering of high-density lipoprotein function

scientific article published on 31 July 2014

Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naïve allergic patients and allergen-challenged mice

scientific article published on 10 September 2019

Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study

scientific article

Atrial fibrillation is associated with alterations in HDL function, metabolism, and particle number

scientific article published on 08 May 2019

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice

scientific article published on 15 September 2018

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

scientific article published on 11 May 2019

Cardiovascular complications in inflammatory bowel disease.

scientific article

Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein

scientific article published on 10 September 2003

Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431-2437

scientific article published on 01 February 2019

Correction: High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration

scientific article published on 3 June 2016

Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease

scientific article published on 21 September 2020

Cyanate is a novel inducer of endothelial icam-1 expression

scientific article published on 14 October 2011

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

scientific article published in April 2018

Dialysis Modalities and HDL Composition and Function

scientific article

Distinct composition of human fetal HDL attenuates its anti-oxidative capacity

article

E-type prostanoid receptor 4 (EP4) in disease and therapy

scientific article

EP4 receptor stimulation down-regulates human eosinophil function.

scientific article

Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.

scientific article

Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study

scientific article published on 15 November 2019

Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking

scientific article

Endothelial lipase increases antioxidative capacity of high-density lipoprotein

scientific article published on 17 June 2019

Endothelium-derived prostaglandin I(2) controls the migration of eosinophils

scientific article published on 11 February 2010

Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.

scientific article published on 29 February 2016

Fetal HDL/apoE: a novel regulator of gene expression in human placental endothelial cells

article

Gestational diabetes mellitus modulates neonatal high-density lipoprotein composition and its functional heterogeneity

article

HDL Cholesterol Efflux Capacity and Cardiovascular Events in Patients With Chronic Kidney Disease

scientific article published on 01 January 2017

HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients.

scientific article

HDL structure and function is profoundly affected when stored frozen in the absence of cryoprotectants

scientific article published on 11 September 2017

HDL subclasses and mortality in acute heart failure patients.

scientific article published on 19 December 2018

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

scientific article published on 01 December 2020

High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration

scientific article

Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1.

scientific article published on 22 January 2009

Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairmen

scientific article published on 06 June 2019

Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoprotein A-I.

scientific article published in June 2001

Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport

scientific article

Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase

scientific article

Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells

scientific article published on 01 April 2001

Imatinib stimulates PGE and attenuates cytokine release via EP4 receptor activation

scientific article published on 16 October 2018

Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein

scientific article published on 2 October 2017

Inflammation alters HDL composition and function: implications for HDL-raising therapies

scientific article published on 14 December 2012

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

scientific article

It's Time to Reassess the High-Density Lipoprotein (HDL) Hypothesis: CSL112, a Novel Promising Reconstituted HDL Formulation

scientific article published on 25 August 2015

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation

scientific article

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation

scientific article published in 2012

Liver disease alters high-density lipoprotein composition, metabolism and function

scientific article published on 19 April 2016

Lp-PLA2, plaque inflammation and lesion development vary fundamentally between different vascular sites

scientific article published on 11 February 2015

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress.

scientific article published on 3 October 2017

Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients.

scientific article

Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans

scientific article published on 20 March 2019

Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice

scientific article published on 29 April 2020

Metrics of High-Density Lipoprotein Function and Hospital Mortality in Acute Heart Failure Patients

scientific article

Microwave-assisted high-throughput acid hydrolysis in silicon carbide microtiter platforms--a rapid and low volume sample preparation technique for total amino acid analysis in proteins and peptides

scientific article published on 21 October 2010

Mode of renal replacement therapy determines endotoxemia and neutrophil dysfunction in chronic kidney disease

scientific article published on 4 October 2016

Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

scientific article

Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: novel pathways generating dysfunctional high-density lipoprotein

scientific article published on 8 May 2012

Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL.

scientific article published on 24 November 2014

O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms

scientific article

Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function

scientific article published on 26 November 2020

Opposing roles of prostaglandin D2 receptors in ulcerative colitis

scientific article

Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression

scientific article published on 24 February 2016

Phospholipid Transfer Protein in the Placental Endothelium Is Affected by Gestational Diabetes Mellitus

scientific article published on 16 November 2011

Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo

scientific article

Protein carbamylation renders high-density lipoprotein dysfunctional

scientific article

Psoriasis alters HDL composition and cholesterol efflux capacity

scientific article published on 30 May 2012

Quantifying the HDL proteome by mass spectrometry: how many proteins truly associate with HDL?

scientific article published on 02 March 2018

Redox state of human serum albumin in terms of cysteine-34 in health and disease.

scientific article published on 20 June 2010

Refined purification strategy for reliable proteomic profiling of HDL2/3: Impact on proteomic complexity.

scientific article published on 05 December 2016

Restoration of renal function does not correct impairment of uremic HDL properties

scientific article

Role of Serum Amyloid A During Metabolism of Acute-Phase HDL by Macrophages

scientific article published on 01 March 2000

Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation

scientific article published on 14 August 2017

Serum Concentration of HDL Particles Predicts Mortality in Acute Heart Failure Patients

scientific article

Still a reasonable goal: Targeting cholesterol in dialysis and advanced chronic kidney disease patients

scientific article published on 19 June 2017

The Distinct Role of the HDL Receptor SR-BI in Cholesterol Homeostasis of Human Placental Arterial and Venous Endothelial Cells

scientific article published on 11 May 2022

The EP3 Agonist Sulprostone Enhances Platelet Adhesion But Not Thrombus Formation Under Flow Conditions.

scientific article published on 30 July 2015

The GPR55 antagonist CID16020046 protects against intestinal inflammation.

scientific article published on 30 July 2015

The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk

scientific article published on 11 August 2017

The atypical cannabinoid O-1602 shows antitumorigenic effects in colon cancer cells and reduces tumor growth in a colitis-associated colon cancer model

The authors reply

The complex high-density lipoprotein proteome: a matter of purification?

scientific article published in December 2017

The effect of carbamylation on the functionality of high-density lipoprotein.

scientific article published on 12 November 2009

The lipidation status of acute-phase protein serum amyloid A determines cholesterol mobilization via scavenger receptor class B, type I.

scientific article published on February 2007

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

scientific article

The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors

scientific article

The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation

scientific article published on 11 November 2010

The urea decomposition product cyanate promotes endothelial dysfunction

scientific article published on 18 June 2014

Understanding high-density lipoprotein function in disease: recent advances in proteomics unravel the complexity of its composition and biology

scientific article

Urea induces intercellular adhesion molecule-1 expression

scientific article published on 5 September 2011

Uremia alters HDL composition and cholesterol efflux capacity.

scientific article published on 17 September 2012

Uremia alters HDL composition and function

scientific article

Uremia-induced lysine modifications transform plasma albumin into a high-density lipoprotein receptor inhibitor.

scientific article published on 17 September 2012

Uremic albumin blocks reverse cholesterol transfer: role of lysine modifications.

scientific article

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

scientific article published on 21 October 2015

List of works by Gunther Marsche

2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis.

A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.

Abnormal composition and function of high-density lipoproteins in atopic dermatitis patients

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung

Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function

Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo.

Adiponectin Predicts High-Density Lipoprotein Cholesterol Efflux Capacity in Adults Irrespective of Body Mass Index and Fat Distribution

Advanced oxidation protein products are antagonists of the HDL receptor SR-BI

Aging affects high-density lipoprotein composition and function

Allergic rhinitis is associated with complex alterations in high-density lipoprotein composition and function

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System ⬇️

Anti-psoriatic therapy recovers high-density lipoprotein composition and function

Antipsoriatic treatment extends beyond the skin: recovering of high-density lipoprotein function

Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naïve allergic patients and allergen-challenged mice

Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study

Atrial fibrillation is associated with alterations in HDL function, metabolism, and particle number

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

Cardiovascular complications in inflammatory bowel disease.

Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein

Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431-2437

Correction: High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration

Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease

Cyanate is a novel inducer of endothelial icam-1 expression

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

Dialysis Modalities and HDL Composition and Function

Distinct composition of human fetal HDL attenuates its anti-oxidative capacity

E-type prostanoid receptor 4 (EP4) in disease and therapy

EP4 receptor stimulation down-regulates human eosinophil function.

Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.

Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study

Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking

Endothelial lipase increases antioxidative capacity of high-density lipoprotein

Endothelium-derived prostaglandin I(2) controls the migration of eosinophils

Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.

Fetal HDL/apoE: a novel regulator of gene expression in human placental endothelial cells

Gestational diabetes mellitus modulates neonatal high-density lipoprotein composition and its functional heterogeneity

HDL Cholesterol Efflux Capacity and Cardiovascular Events in Patients With Chronic Kidney Disease

HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients.

HDL structure and function is profoundly affected when stored frozen in the absence of cryoprotectants

HDL subclasses and mortality in acute heart failure patients.

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration

Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1.

Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairmen

Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoprotein A-I.

Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport

Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase

Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells

Imatinib stimulates PGE and attenuates cytokine release via EP4 receptor activation

Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein

Inflammation alters HDL composition and function: implications for HDL-raising therapies

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

It's Time to Reassess the High-Density Lipoprotein (HDL) Hypothesis: CSL112, a Novel Promising Reconstituted HDL Formulation

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation

Liver disease alters high-density lipoprotein composition, metabolism and function

Lp-PLA2, plaque inflammation and lesion development vary fundamentally between different vascular sites

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress.

Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients.

Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans

Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice

Metrics of High-Density Lipoprotein Function and Hospital Mortality in Acute Heart Failure Patients

Microwave-assisted high-throughput acid hydrolysis in silicon carbide microtiter platforms--a rapid and low volume sample preparation technique for total amino acid analysis in proteins and peptides

Mode of renal replacement therapy determines endotoxemia and neutrophil dysfunction in chronic kidney disease

Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: novel pathways generating dysfunctional high-density lipoprotein

Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL.

O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms

Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function

Opposing roles of prostaglandin D2 receptors in ulcerative colitis

Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression

Phospholipid Transfer Protein in the Placental Endothelium Is Affected by Gestational Diabetes Mellitus

Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo

Protein carbamylation renders high-density lipoprotein dysfunctional

Psoriasis alters HDL composition and cholesterol efflux capacity

Quantifying the HDL proteome by mass spectrometry: how many proteins truly associate with HDL?

Redox state of human serum albumin in terms of cysteine-34 in health and disease.

Refined purification strategy for reliable proteomic profiling of HDL2/3: Impact on proteomic complexity.