List of works by Juan M. Irache

A Brucella ovis antigenic complex bearing poly-epsilon-caprolactone microparticles confer protection against experimental brucellosis in mice

scientific article published on 01 July 2001

A combination of nanosystems for the delivery of cancer chemoimmunotherapeutic combinations: 1-Methyltryptophan nanocrystals and paclitaxel nanoparticles

scientific article published on 8 September 2017

A novel nanoparticulate adjuvant for immunotherapy with Lolium perenne.

scientific article published on 21 June 2009

Adaptive immune responses of legumin nanoparticles

scientific article published in December 2002

Adjuvants for allergy immunotherapeutics.

scientific article published on 21 August 2017

Albumin nanoparticles as carriers for a phosphodiester oligonucleotide

scientific article published on 01 September 2002

Albumin nanoparticles improved the stability, nuclear accumulation and anticytomegaloviral activity of a phosphodiester oligonucleotide.

scientific article published on January 2004

Allergen immunotherapy with nanoparticles containing lipopolysaccharide from Brucella ovis

scientific article published on 06 June 2008

Amikacin loaded PLGA nanoparticles against Pseudomonas aeruginosa

scientific article published on 26 August 2016

An HPLC with evaporative light scattering detection method for the quantification of PEGs and Gantrez in PEGylated nanoparticles.

scientific article

Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice

scientific article

Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice

scientific article published on 09 September 2020

Bioadhesion of lectin-latex conjugates to rat intestinal mucosa

scientific article published on 01 November 1996

Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles

scientific article published in November 2007

Bioadhesive potential of gliadin nanoparticulate systems

scientific article published on 01 October 2000

Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.

scientific article published on 28 February 2009

Bioadhesive properties of Gantrez nanoparticles

scientific article published on 31 January 2005

Bioadhesive properties of pegylated nanoparticles.

scientific article

Bovine serum albumin modified the intracellular distribution and improved the antiviral activity of an oligonucleotide.

scientific article published on May 2003

Brucella outer membrane complex-loaded microparticles as a vaccine against Brucella ovis in rams

scientific article published on 4 November 2005

Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin

scientific article published on 28 August 2019

Co-delivery of ovalbumin and CpG motifs into microparticles protected sensitized mice from anaphylaxis

scientific article published on 06 January 2009

Co-encapsulated CpG oligodeoxynucleotides and ovalbumin in PLGA microparticles; an in vitro and in vivo study

scientific article published on October 2014

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology

scientific article published on 31 March 2008

Coencapsulation of cyclodextrins into poly(anhydride) nanoparticles to improve the oral administration of glibenclamide. A screening on C. elegans

scientific article published on 21 December 2017

Combined hydroxypropyl-beta-cyclodextrin and poly(anhydride) nanoparticles improve the oral permeability of paclitaxel

scientific article published on 16 September 2009

Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles

scientific article published on 28 July 2012

Controlled Release, Intestinal Transport, and Oral Bioavailablity of Paclitaxel Can be Considerably Increased Using Suitably Tailored Pegylated Poly(Anhydride) Nanoparticles

scientific article published on 19 January 2015

Cyclodextrin-grafted poly(anhydride) nanoparticles for oral glibenclamide administration. In vivo evaluation using C. elegans

scientific article published on 26 May 2018

Cyclodextrin-poly(anhydride) nanoparticles as new vehicles for oral drug delivery.

scientific article published on 04 April 2011

Cyclodextrin/poly(anhydride) nanoparticles as drug carriers for the oral delivery of atovaquone

scientific article published on 01 December 2011

Cytotoxicity and cell interaction studies of bioadhesive poly(anhydride) nanoparticles for oral antigen/drug delivery.

scientific article published on November 2013

Design and influence of gamma-irradiation on the biopharmaceutical properties of nanoparticles containing an antigenic complex from Brucella ovis

scientific article published on 12 May 2009

Determination of oligonucleotide ISIS 2922 in nanoparticulate delivery systems by capillary zone electrophoresis

scientific article published on 01 February 2000

Development and validation of a HPLC method for the determination of cyclosporine a in new bioadhesive nanoparticles for oral administration

scientific article published on March 2014

Development of a bacterial nanoparticle vaccine.

scientific article published in January 2015

Development of a sensitive method for the determination of ganciclovir by reversed-phase high-performance liquid chromatography

scientific article published on 01 February 2000

Development of bioadhesive amino-pegylated poly(anhydride) nanoparticles designed for oral DNA delivery

scientific article published on 01 March 2008

Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis.

scientific article published on August 2002

Development of poly(anhydride) nanoparticles loaded with peanut proteins: the influence of preparation method on the immunogenic properties

scientific article published on 08 July 2012

Different approaches for determination of the attachment degree of polyethylene glycols to poly(anhydride) nanoparticles

scientific article published on 01 June 2010

Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease

scientific article

Encapsulation of antigenic extracts of Salmonella enterica serovar. Abortusovis into polymeric systems and efficacy as vaccines in mice.

scientific article published on 17 August 2006

Encapsulation of probiotics in soybean protein-based microparticles preserves viable cell concentration in foods all along the production and storage processes

scientific article published on 09 February 2020

Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions

scientific article published on 13 November 2019

Evaluation of bioadhesive capacity and immunoadjuvant properties of vitamin B(12)-Gantrez nanoparticles

scientific article

Evaluation of bioadhesive potential and intestinal transport of pegylated poly(anhydride) nanoparticles.

scientific article

Evaluation of particulate acellular vaccines against Brucella ovis infection in rams

scientific article published on 01 November 2009

Evaluation of the cytotoxicity, genotoxicity and mucus permeation capacity of several surface modified poly(anhydride) nanoparticles designed for oral drug delivery.

scientific article published on 28 November 2016

Evaluation of the treatment with resveratrol-loaded nanoparticles in intestinal injury model caused by ischemia and reperfusion

scientific article published on 7 February 2018

Experiments on a sub-unit vaccine encapsulated in microparticles and its efficacy against Brucella melitensis in mice.

scientific article published on 31 January 2006

Fluconazole encapsulation in PLGA microspheres by spray-drying.

scientific article

Gamma interferon loaded onto albumin nanoparticles: in vitro and in vivo activities against Brucella abortus.

scientific article published on 12 January 2007

Ganciclovir-loaded albumin nanoparticles: characterization and in vitro release properties.

scientific article

Gantrez AN Nanoparticles for Ocular Delivery of Memantine: In vitro Release Evaluation in Albino Rabbits

scientific article published on 21 April 2012

Gantrez AN as a new polymer for the preparation of ligand-nanoparticle conjugates

scientific article published in October 2002

Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens

article

Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections

scientific article published on 01 February 2000

Gentamicin-loaded microspheres for reducing the intracellular Brucella abortus load in infected monocytes.

scientific article published on 21 April 2004

Gentamicin-loaded microspheres for treatment of experimental Brucella abortus infection in mice.

scientific article published on 9 May 2005

Gliadin nanoparticles as carriers for the oral administration of lipophilic drugs. Relationships between bioadhesion and pharmacokinetics

scientific article published in November 2001

Humoral immune response in hens naturally infected with Salmonella Enteritidis against outer membrane proteins and other surface structural antigens

scientific article published in May 2004

Immune Response after Skin Delivery of a Recombinant Heat-Labile Enterotoxin B Subunit of Enterotoxigenic Escherichia coli in Mice

scientific article published in 2022

Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination.

scientific article

Immunogenicity of peanut proteins containing poly(anhydride) nanoparticles

scientific article

In vitro antileishmanial activity of amphotericin B loaded in poly(epsilon-caprolactone) nanospheres

scientific article published in December 2002

In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery

scientific article published on 9 March 2017

In vitro phagocytosis and monocyte-macrophage activation with poly(lactide) and poly(lactide-co-glycolide) microspheres.

scientific article published in March 2002

In vivo efficacy of bevacizumab-loaded albumin nanoparticles in the treatment of colorectal cancer

scientific article published on 10 February 2020

In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration

scientific article published on 23 December 2014

In vivo sustained release of adenoviral vectors from poly(D,L-lactic-co-glycolic) acid microparticles prepared by TROMS.

scientific article published in January 2004

Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles

scientific article published on 18 September 2018

Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly(anhydride) nanoparticles

scientific article published on 27 March 2010

Influence of dextran on the bioadhesive properties of poly(anhydride) nanoparticles.

scientific article published on 25 August 2009

Influence of the chitosan nature on the transfection efficacy of DNA-loaded nanoparticles after hydrodynamic administration in mice

scientific article published in January 2010

Influence of the co-encapsulation of different excipients on the properties of polyester microparticle-based vaccine against brucellosis

scientific article published on 01 March 2004

Influence of the surface characteristics of PVM/MA nanoparticles on their bioadhesive properties

scientific article published in April 2003

Innovative lead compounds and formulation strategies as newer kinetoplastid therapies.

scientific article published on January 2012

Interactions of poly (anhydride) nanoparticles with macrophages in light of their vaccine adjuvant properties.

scientific article published on 11 October 2015

Intradermal immunization with ovalbumin-loaded poly-epsilon-caprolactone microparticles conferred protection in ovalbumin-sensitized allergic mice

scientific article published on 01 February 2007

Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.

scientific article

Loading of plasmid DNA into PLGA microparticles using TROMS (Total Recirculation One-Machine System): evaluation of its integrity and controlled release properties

scientific article published in January 2003

Low efficacy of NcGRA7, NcSAG4, NcBSR4 and NcSRS9 formulated in poly-ε-caprolactone against Neospora caninum infection in mice.

scientific article published on 26 May 2012

Mannose-targeted systems for the delivery of therapeutics

scientific article published on 01 June 2008

Maternal Vaccination. Immunization of Sows during Pregnancy against ETEC Infections

scientific article

Mimicking microbial strategies for the design of mucus-permeating nanoparticles for oral immunization

scientific article

Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate

scientific article published on 25 January 2019

Molecular buckets: cyclodextrins for oral cancer therapy.

scientific article published on January 2012

Molecular imaging techniques to study the biodistribution of orally administered (99m)Tc-labelled naive and ligand-tagged nanoparticles.

scientific article published in December 2011

Mucoadhesion of latexes. I. Analytical methods and kinetic studies

scientific article published on 01 May 1994

Mucoadhesion of latexes. II. Adsorption isotherms and desorption studies

scientific article published on 01 May 1994

Mucosal immunization with Shigella flexneri outer membrane vesicles induced protection in mice

scientific article published on 10 September 2011

Nanoaggregation of inclusion complexes of glibenclamide with cyclodextrins

scientific article published on 19 January 2017

Nanoparticle based-immunotherapy against allergy.

scientific article published on January 2014

Nanoparticle-based vaccine for mucosal protection against Shigella flexneri in mice

scientific article

Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasis

scientific article published on 12 March 2014

Nanoparticles from Gantrez® AN-poly(ethylene glycol) conjugates as carriers for oral delivery of docetaxel

scientific article published on 16 September 2019

Nanoparticles with specific bioadhesive properties to circumvent the pre-systemic degradation of fluorinated pyrimidines

scientific article published in April 2004

Nanoparticulate adjuvants and delivery systems for allergen immunotherapy

scientific article

New adjuvants: from empiricism to science

scientific article published on 01 October 2009

New methodologies to characterize the effectiveness of the gene transfer mediated by DNA-chitosan nanoparticles.

scientific article published on January 2008

New pharmaceutical approaches for the treatment of food allergies.

scientific article

Ocular disposition and tolerance of ganciclovir-loaded albumin nanoparticles after intravitreal injection in rats

scientific article published in April 2002

Optimization of maghemite-loaded PLGA nanospheres for biomedical applications

scientific article

Optimization of the entrapment of bacterial cell envelope extracts into microparticles for vaccine delivery.

scientific article published in March 2006

Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles

scientific article published on 31 December 2019

Oral Immunogenicity of Enterotoxigenic Escherichia coli Outer Membrane Vesicles Encapsulated into Zein Nanoparticles Coated with a Gantrez® AN–Mannosamine Polymer Conjugate

scientific article published in 2022

Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study

scientific article published on 10 April 2012

Oral delivery of camptothecin using cyclodextrin/poly(anhydride) nanoparticles

scientific article published on 18 April 2016

Oral immunotherapy using polymeric nanoparticles loaded with peanut proteins in a murine model of fatal anaphylaxis.

scientific article published in November 2017

Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): preparation and evaluation of their bioadhesive properties

scientific article published on 01 April 2005

Pegylated nanoparticles for the oral delivery of nimodipine: Pharmacokinetics and effect on the anxiety and cognition in mice.

scientific article published on 28 March 2018

Pegylated poly(anhydride) nanoparticles for oral delivery of docetaxel

scientific article published on 26 March 2018

Pharmacokinetics and antitumor efficacy of paclitaxel-cyclodextrin complexes loaded in mucus-penetrating nanoparticles for oral administration.

scientific article published on 28 January 2014

Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells.

scientific article published on 10 August 2016

Poly(anhydride) nanoparticles containing cashew nut proteins can induce a strong Th1 and Treg immune response after oral administration

scientific article published on 8 February 2018

Poly(ethylene oxide)-block-poly(n-butyl acrylate)-block-poly(acrylic acid) triblock terpolymers with highly asymmetric hydrophilic blocks: synthesis and aqueous solution properties

Poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as innate immune system activators

scientific article published on 07 June 2011

Polyester microparticles as a vaccine delivery system for brucellosis: influence of the polymer on release, phagocytosis and toxicity

Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice.

scientific article published on 29 July 2003

Potential of albumin nanoparticles as carriers for interferon gamma

scientific article published in March 2005

Preparation and characterization of lectin-latex conjugates for specific bioadhesion

scientific article published on 01 September 1994

Preparation of Ulex europaeus lectin-gliadin nanoparticle conjugates and their interaction with gastrointestinal mucus

scientific article published on 01 November 1999

Protective Passive Immunity in Escherichia coli ETEC-Challenged Neonatal Mice Conferred by Orally Immunized Dams with Nanoparticles Containing Homologous Outer Membrane Vesicles

scientific article published on 08 June 2020

Protective ability of subcellular extracts from Salmonella Enteritidis and from a rough isogenic mutant against salmonellosis in mice

scientific article published in February 2005

Protective immunity of biodegradable nanoparticle-based vaccine against an experimental challenge with Salmonella Enteritidis in mice.

scientific article

Quantification of the bioadhesive properties of protein-coated PVM/MA nanoparticles

scientific article published in August 2002

RP-LC determination of 5-fluorouridine in nanoparticulate formulations

scientific article published in June 2002

Salmonella-like bioadhesive nanoparticles

scientific article published in August 2005

Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract.

scientific article

Stability of poly(epsilon-caprolactone) microparticles containing Brucella ovis antigens as a vaccine delivery system against brucellosis.

scientific article published on 16 October 2008

Stability of some phenolic antioxidants in fatty preparations

scientific article published on 01 September 1993

Stabilized micelles as delivery vehicles for paclitaxel

scientific article published on 18 June 2012

Synthesis of Electroneutralized Amphiphilic Copolymers with Peptide Dendrons for Intramuscular Gene Delivery

scientific article

The effect of thiamine-coating nanoparticles on their biodistribution and fate following oral administration

scientific article published on 23 November 2018

Thermosensitive hydrogels of poly(methyl vinyl ether-co-maleic anhydride) - Pluronic(®) F127 copolymers for controlled protein release.

scientific article

Topical treatment of L. major infected BALB/c mice with a novel diselenide chitosan hydrogel formulation

scientific article

Towards a non-living vaccine against Shigella flexneri: from the inactivation procedure to protection studies

scientific article published on 06 October 2012

Toxicity and biodistribution of orally administered casein nanoparticles

scientific article published on 10 June 2017

Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs.

scientific article

Toxicity studies of poly(anhydride) nanoparticles as carriers for oral drug delivery

scientific article published on 26 May 2012

Zein nanoparticles for oral delivery of quercetin: Pharmacokinetic studies and preventive anti-inflammatory effects in a mouse model of endotoxemia.

scientific article published on 8 September 2016

Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic Shock

scientific article published on 9 June 2015

Zein-based nanoparticles for the oral delivery of insulin

scientific article published on 08 June 2020

[Mucopenetrating nanoparticles: vehicles for the oral administration of paclitaxel]

scientific article published on 27 February 2013

[Radiolabeling and biodistribution studies of polymeric nanoparticles as adjuvants for ocular vaccination against brucellosis]

scientific article published on 16 January 2013

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