List of works - Jacques Archambault

A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication

scientific article

A high-throughput cellular assay to quantify the p53-degradation activity of E6 from different human papillomavirus types.

scientific article

A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae

scientific article

A quantitative and high-throughput assay of human papillomavirus DNA replication

scientific article

Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4

scientific article

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

scientific article published in December 1997

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

scientific article

Analysis of JC virus DNA replication using a quantitative and high-throughput assay.

scientific article published on 24 August 2014

Ano-genital human papillomavirus type 97 infection is detected in Canadian men but not women at risk or infected with the human immunodeficiency virus

scientific article

Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication

scientific article published on April 2015

Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486

scientific article published on December 2005

Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms.

scientific article published on 14 July 2015

Characterization of an HPV33 natural variant with enhanced transcriptional activity suggests a role for C/EBPβ in the regulation of the viral early promoter

scientific article published on 25 March 2019

Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9.

scientific article published on December 2009

Characterization of recombinant HPV6 and 11 E1 helicases: effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain.

scientific article published on 13 April 2001

Characterization of the DNA-binding properties of the origin-binding domain of simian virus 40 large T antigen by fluorescence anisotropy

scientific article

Characterization of the binding site for inhibitors of the HPV11 E1-E2 protein interaction on the E2 transactivation domain by photoaffinity labeling and mass spectrometry

scientific article published in April 2004

Characterization of the minimal DNA binding domain of the human papillomavirus e1 helicase: fluorescence anisotropy studies and characterization of a dimerization-defective mutant protein

scientific article

Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor

scientific article

Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication

scientific article

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

scientific article

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

scientific article

E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication

scientific article

FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO

scientific article

Genetic analysis of the E2 transactivation domain dimerization interface from bovine papillomavirus type 1.

scientific article published on 11 March 2013

Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes

scientific article

Human papillomavirus type 52 polymorphism and high-grade lesions of the uterine cervix

scientific article

Human papillomavirus type 56 polymorphism in Canadian women with and without cervical lesions

scientific article published on 17 October 2013

Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification

scholarly article

Identification of domains of the HPV11 E1 protein required for DNA replication in vitro

scientific article

Identification of domains of the human papillomavirus type 11 E1 helicase involved in oligomerization and binding to the viral origin

scientific article

In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS

scientific article

Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide

scientific article published on 25 January 2012

Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

scientific article published on 30 April 2003

Inhibitors of Multisubunit RNA Polymerases as Tools to Study Transcriptional Mechanisms in Prokaryotes and Eukaryotes

article

Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain

scientific article

Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes

scientific article published on 19 March 2019

Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1

scientific journal article

Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response

scientific article

Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.

scientific article published on 7 February 2007

Molecular mechanisms of human papillomavirus-induced carcinogenesis.

scientific article

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network

scientific article published on 12 September 2018

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1

scientific article

Naturally Occurring Variations Modulate the Activity of the HPV33 Early Promoter and its Affinity for the E2 Transcription Factor

scientific article published in Scientific Reports

Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response

scientific article (publication date: September 2011)

Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance

scientific article

Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.

scientific article

Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.

scientific article

Site-directed mutagenesis, purification and assay of Saccharomyces cerevisiae RNA polymerase II.

scientific article published on 28 June 2009

Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains

scientific article published on 6 January 2016

Structural and Functional Characterization of a Complex between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 Subunit of TFIIH

scientific article

Structural characterization of a noncovalent complex between ubiquitin and the transactivation domain of the erythroid-specific factor EKLF

scientific article

Structural perspective on mutations affecting the function of multisubunit RNA polymerases

scientific article

Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA

scientific article

Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain ⬇️

scientific article

Targeting human papillomavirus genome replication for antiviral drug discovery

scientific article

The E1 proteins

scientific article published on 10 September 2013

The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II.

scientific article

p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH

scientific article

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes

scientific article published on 19 October 2011

List of works by Jacques Archambault

A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication

A high-throughput cellular assay to quantify the p53-degradation activity of E6 from different human papillomavirus types.

A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae

A quantitative and high-throughput assay of human papillomavirus DNA replication

Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

Analysis of JC virus DNA replication using a quantitative and high-throughput assay.

Ano-genital human papillomavirus type 97 infection is detected in Canadian men but not women at risk or infected with the human immunodeficiency virus

Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication

Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486

Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms.

Characterization of an HPV33 natural variant with enhanced transcriptional activity suggests a role for C/EBPβ in the regulation of the viral early promoter

Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9.

Characterization of recombinant HPV6 and 11 E1 helicases: effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain.

Characterization of the DNA-binding properties of the origin-binding domain of simian virus 40 large T antigen by fluorescence anisotropy

Characterization of the binding site for inhibitors of the HPV11 E1-E2 protein interaction on the E2 transactivation domain by photoaffinity labeling and mass spectrometry

Characterization of the minimal DNA binding domain of the human papillomavirus e1 helicase: fluorescence anisotropy studies and characterization of a dimerization-defective mutant protein

Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor

Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication

FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO

Genetic analysis of the E2 transactivation domain dimerization interface from bovine papillomavirus type 1.

Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes

Human papillomavirus type 52 polymorphism and high-grade lesions of the uterine cervix

Human papillomavirus type 56 polymorphism in Canadian women with and without cervical lesions

Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification

Identification of domains of the HPV11 E1 protein required for DNA replication in vitro

Identification of domains of the human papillomavirus type 11 E1 helicase involved in oligomerization and binding to the viral origin

In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS

Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide

Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

Inhibitors of Multisubunit RNA Polymerases as Tools to Study Transcriptional Mechanisms in Prokaryotes and Eukaryotes

Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain

Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes

Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1

Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response

Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.

Molecular mechanisms of human papillomavirus-induced carcinogenesis.

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1

Naturally Occurring Variations Modulate the Activity of the HPV33 Early Promoter and its Affinity for the E2 Transcription Factor

Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response

Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance

Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.

Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.

Site-directed mutagenesis, purification and assay of Saccharomyces cerevisiae RNA polymerase II.

Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains

Structural and Functional Characterization of a Complex between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 Subunit of TFIIH

Structural characterization of a noncovalent complex between ubiquitin and the transactivation domain of the erythroid-specific factor EKLF

Structural perspective on mutations affecting the function of multisubunit RNA polymerases

Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA

Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain ⬇️

Targeting human papillomavirus genome replication for antiviral drug discovery

The E1 proteins

The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II.

p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes