List of works - Detlev Boison

A Breather for SUDEP.

scientific article published on May 2012

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.

scientific article

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors

scientific article published on 23 June 2011

A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.

scientific article

A scaffold as a platform for new therapies?

scientific article published on September 2012

Adenosine A1 receptors are crucial in keeping an epileptic focus localized

scientific article

Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.

scientific article

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.

scientific article

Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction.

scientific article published on 03 June 2016

Adenosine Receptors and Alzheimer’s Disease

Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies.

scientific article

Adenosine and seizure termination: endogenous mechanisms

scientific article published in January 2013

Adenosine as a modulator of brain activity.

scientific article published on December 2007

Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.

scientific article

Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies.

scientific article published on 09 May 2009

Adenosine dysfunction in epilepsy

scientific article

Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy

scientific article

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

scientific article published on 09 April 2021

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.

scientific article

Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss

scientific article

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss

scientific article published on 26 December 2016

Adenosine signaling and function in glial cells

scientific article

Adenosine-based cell therapy approaches for pharmacoresistant epilepsies.

scientific article published on January 2007

Adenosine-based modulation of brain activity.

scientific article published on September 2009

Adenosinergic signaling in epilepsy

scientific article published on September 2015

Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1

scientific article published on 28 March 2009

Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures

scientific article published in August 2003

Antiepileptic effects of silk-polymer based adenosine release in kindled rats.

scientific article published on 19 May 2009

Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.

scientific article

Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery.

scientific article

Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.

scientific article published on 10 October 2008

Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation

scientific article published in June 2005

Cell and gene therapies for refractory epilepsy.

scientific article published on January 2007

Chopping Out CHOP Chops the Fate of Neurons

scientific article published on September 2013

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

scientific article published on 15 December 2017

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia

scientific article published on 21 April 2020

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle.

scientific article published on 29 August 2017

Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve

scientific article published on 01 August 1995

Deep brain stimulation in the dish: focus on mechanisms.

scientific article published on July 2014

Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia

scientific article

Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?

scientific article published on October 2009

Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning

scientific article

Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior

scientific article published on 23 August 2018

Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.

scientific article

Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.

scientific article published on 25 April 2007

Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation

scientific article published on 20 October 2016

Editorial: Metabolic Control of Brain Homeostasis.

scientific article published on 9 June 2017

Engineering Human Mesenchymal Stem Cells to Release Adenosine Using miRNA Technology

scientific article published in January 2017

Engineering embryonic stem cell derived glia for adenosine delivery

scientific article published in November 2004

Engineering human mesenchymal stem cells to release adenosine using miRNA technology

scientific article published on January 1, 2010

Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons

scientific article published in October 2007

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

scientific article published in January 2005

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.

scientific article

Epilepsy and astrocyte energy metabolism.

scientific article published on 17 October 2017

Epilepsy: crucial role for astrocytes

scientific article published on 01 August 2012

From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

scientific article published on April 2014

From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy

scientific article

Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.

scientific article published in August 1997

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development

scientific article published on 4 June 2015

Glowing feet control the blood of seizures

scientific article published on May 2013

Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: evidence from genetically modified mouse models and pharmacological inhibition

scientific article published on 17 February 2011

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

scientific article

Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy

scientific article

Homeostatic control of brain function - new approaches to understand epileptogenesis.

scientific article published on 16 July 2013

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

scientific article

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning ⬇️

scientific article published on December 1, 2010

Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release

scientific article

Inhibition of Adenosine Kinase Attenuates Acute Lung Injury

scientific article published on 21 October 2015

Inhibitory RNA in epilepsy: research tools and therapeutic perspectives

scientific article

Intact working memory in the absence of forebrain neuronal glycine transporter 1.

scientific article published on 8 February 2012

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis.

scientific article published on 27 July 2017

Is Intrinsic Hyperexcitability in CA3 the Culprit for Seizures in Rett Syndrome?

scientific article published on January 2012

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

scientific article published on 6 August 2015

Ketogenic diet sensitizes glucose control of hippocampal excitability.

scientific article

Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control.

scientific article

Manipulation of adenosine kinase affects sleep regulation in mice

scientific article

Methylxanthines, seizures, and excitotoxicity.

scientific article

Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice

scientific article

Modulators of nucleoside metabolism in the therapy of brain diseases.

scientific article

Mouse Oocytes Acquire Mechanisms That Permit Independent Cell Volume Regulation at the End of Oogenesis.

scientific article

Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.

scientific article published on 22 November 2006

New insights into the mechanisms of the ketogenic diet.

scientific article published on 30 January 2017

Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice

scientific article

Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis

scientific journal article

Purines: forgotten mediators in traumatic brain injury.

scientific article published on 26 January 2016

Quantitative analysis of adenosine using liquid chromatography/atmospheric pressure chemical ionization-tandem mass spectrometry (LC/APCI-MS/MS)

scientific article

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.

scientific article published on 16 October 2017

Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain.

scientific article

Role of adenosine in status epilepticus: a potential new target?

scientific article

Role of adenosine kinase in cochlear development and response to noise

scientific article

Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts

scientific article

Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy

scientific article published in September 2002

Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy

scientific article

Seizure suppression by adenosine-releasing cells is independent of seizure frequency

scientific article published in August 2002

Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning.

scientific article

Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme.

scientific article published on 20 July 2006

Silk fibroin encapsulated powder reservoirs for sustained release of adenosine

scientific article

South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.

scientific article published on 13 July 2016

Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants.

scientific article

The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine

scientific article

The adenosine kinase hypothesis of epileptogenesis

scientific article published on 23 December 2007

The role of adenosine in alcohol-induced respiratory suppression

scientific article published in 2023

The role of adenosine in epilepsy

scientific article published on 20 November 2018

The sound of noninvasive seizure control

scientific article

The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.

scientific article

The use of real-time PCR with fluorogenic probes for the rapid selection of mutant neuroectodermal grafts

scientific article published in October 2002

Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation

scientific article

Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.

scientific article

Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs

scientific article published on 14 November 2007

Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice

scientific article published on 27 February 2019

Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice

scientific article

When GABA Fails: Rundown on Chemokines.

scientific article published on May 2014

entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse

scientific article

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

scientific article

List of works by Detlev Boison

A Breather for SUDEP.

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors

A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.

A scaffold as a platform for new therapies?

Adenosine A1 receptors are crucial in keeping an epileptic focus localized

Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.

Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction.

Adenosine Receptors and Alzheimer’s Disease

Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies.

Adenosine and seizure termination: endogenous mechanisms

Adenosine as a modulator of brain activity.

Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.

Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies.

Adenosine dysfunction in epilepsy

Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.

Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss

Adenosine signaling and function in glial cells

Adenosine-based cell therapy approaches for pharmacoresistant epilepsies.

Adenosine-based modulation of brain activity.

Adenosinergic signaling in epilepsy

Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1

Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures

Antiepileptic effects of silk-polymer based adenosine release in kindled rats.

Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.

Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery.

Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.

Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation

Cell and gene therapies for refractory epilepsy.

Chopping Out CHOP Chops the Fate of Neurons

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle.

Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve

Deep brain stimulation in the dish: focus on mechanisms.

Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia

Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?

Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning

Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior

Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.

Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.

Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation

Editorial: Metabolic Control of Brain Homeostasis.

Engineering Human Mesenchymal Stem Cells to Release Adenosine Using miRNA Technology

Engineering embryonic stem cell derived glia for adenosine delivery

Engineering human mesenchymal stem cells to release adenosine using miRNA technology

Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.

Epilepsy and astrocyte energy metabolism.

Epilepsy: crucial role for astrocytes

From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy

Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development

Glowing feet control the blood of seizures

Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: evidence from genetically modified mouse models and pharmacological inhibition

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy

Homeostatic control of brain function - new approaches to understand epileptogenesis.

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning ⬇️

Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release

Inhibition of Adenosine Kinase Attenuates Acute Lung Injury

Inhibitory RNA in epilepsy: research tools and therapeutic perspectives

Intact working memory in the absence of forebrain neuronal glycine transporter 1.

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis.

Is Intrinsic Hyperexcitability in CA3 the Culprit for Seizures in Rett Syndrome?

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

Ketogenic diet sensitizes glucose control of hippocampal excitability.

Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control.

Manipulation of adenosine kinase affects sleep regulation in mice

Methylxanthines, seizures, and excitotoxicity.

Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice

Modulators of nucleoside metabolism in the therapy of brain diseases.