List of works - Mark Pritchard

68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management

scientific article published on 12 April 2017

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

scientific article published on 04 August 2016

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

scientific article published on 15 August 2013

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

scientific article

Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection

scientific article published on 05 April 2007

Analysis of clinical isolates of Helicobacter pylori in Pakistan reveals high degrees of pathogenicity and high frequencies of antibiotic resistance

scientific article

Apoptosis and gastrointestinal pharmacology.

scientific article

Assessment of the efficacy and toxicity of (131)I-metaiodobenzylguanidine therapy for metastatic neuroendocrine tumours

scientific article published on 19 February 2008

Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.

scientific article published in January 2000

Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine

scientific article published on 01 August 2000

CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach.

scientific article published on 16 August 2012

COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo

scientific article published on 14 October 2004

CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.

scientific article published on 26 October 2012

Characterization of epithelial cell shedding from human small intestine.

scientific article

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis.

scientific article

Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis.

scientific article published on 02 January 2014

Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use

scholarly article published 1 June 2017

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.

scientific article

Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia

scientific article

Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy

scientific article published on 07 July 2018

Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis.

scientific article published in November 2013

Correlation between a short-term intravenous octreotide suppression test and response to antrectomy in patients with type-1 gastric neuroendocrine tumours

scientific article published on 01 April 2013

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

scientific journal article

Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-center Experience.

scientific article published on 20 October 2017

Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?

scientific article published on 20 September 2017

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip

scientific article

Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.

scientific article

Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse

scientific article

Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor.

scientific article published on 21 August 2008

Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor

scientific article

Gastrin receptor pharmacology.

scientific article

Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration.

scientific article published on 14 May 2015

Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells.

scientific article published on 30 December 2010

Gastrin-induced apoptosis contributes to carcinogenesis in the stomach

scientific article published on 07 August 2006

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1.

scientific article published on 14 June 2016

Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression.

scientific article

Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements.

scientific article published on 26 April 2007

Helicobacter pylori and gastric cancer

scientific article published on 01 November 2006

Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis.

scientific article published on March 2004

Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population

scientific article

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.

scientific article published on February 2017

Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice.

scientific article published on 27 February 2017

Hypergastrinemia increases gastric epithelial susceptibility to apoptosis.

scientific article published on 7 September 2007

IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis

scientific article

Importance of gastrin in the pathogenesis and treatment of gastric tumors

scientific article published in January 2009

Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.

scientific article published on 21 April 2016

In Reply to Habr-Gama et al

scientific article published on 01 July 2018

Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium

scientific article published on 11 February 2013

Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling.

scientific article published on 11 January 2007

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

scientific article

Intestinal Preparation Techniques for Histological Analysis in the Mouse.

scientific article published on June 2016

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

scientific article published on 24 December 2008

Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice

scientific article

Letter: gastric cancer and pernicious anaemia--only a minority of UK pernicious anaemia patients have had a gastroscopy

scientific article published on 01 May 2016

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

scientific article

Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance.

scientific article

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.

scientific article published on 20 July 2017

Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer

scientific article published on June 2015

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice

scientific article published on 21 April 2015

Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis

scientific article

Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis

scientific article published on 4 October 2016

Oral iron exacerbates colitis and influences the intestinal microbiome

scientific article published in PLoS ONE

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation

scientific article

Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1.

scientific article published on May 2007

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1.

scientific article published on 17 October 2014

Peptide receptor radionuclide therapy with (90)Y-DOTATATE/(90)Y-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity

scientific article published on 14 March 2013

Potential clinical indications for a CCK2 receptor antagonist

scientific article

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice

scientific article published on 25 October 2018

Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo.

scientific article

Progastrin stimulates murine colonic epithelial mitosis after DNA damage

scientific article published on 01 May 2003

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

scientific article published on 31 August 2013

Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS).

scientific article published on 18 August 2017

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

scientific journal article

Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest.

scientific article published on September 1998

Review article: How useful are the rodent animal models of gastric adenocarcinoma?

scientific article published on April 2004

Review article: Pathogenesis and management of gastric carcinoid tumours.

scientific article published on November 2006

Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality.

scientific article published on 11 September 2014

Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice.

scientific article published on 26 August 2013

Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice

scientific article

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

scientific article published on 5 June 2018

The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study

scientific article

The clinical presentation and management of carcinoid heart disease.

scientific article published on 28 February 2014

The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): genetic differences between BALB/c and DBA/2 mice

scientific article published on 01 November 2000

The management of gastric polyps

scientific article published on 30 July 2010

The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia

scientific article published on 01 December 1998

The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010.

scientific article

The stomach in health and disease

scientific article

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

scientific article published on 26 January 2017

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

scientific article published on 21 September 2020

Zollinger-Ellison syndrome: still a diagnostic challenge in the 21st century?

scientific article published on 26 March 2011

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice.

scientific article

List of works by Mark Pritchard

68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection

Analysis of clinical isolates of Helicobacter pylori in Pakistan reveals high degrees of pathogenicity and high frequencies of antibiotic resistance

Apoptosis and gastrointestinal pharmacology.

Assessment of the efficacy and toxicity of (131)I-metaiodobenzylguanidine therapy for metastatic neuroendocrine tumours

Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.

Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine

CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach.

COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo

CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.

Characterization of epithelial cell shedding from human small intestine.

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis.

Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis.

Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.

Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia

Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy

Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis.

Correlation between a short-term intravenous octreotide suppression test and response to antrectomy in patients with type-1 gastric neuroendocrine tumours

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-center Experience.

Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip

Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.

Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse

Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor.

Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor

Gastrin receptor pharmacology.

Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration.

Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells.

Gastrin-induced apoptosis contributes to carcinogenesis in the stomach

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1.

Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression.

Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements.

Helicobacter pylori and gastric cancer

Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis.

Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.

Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice.

Hypergastrinemia increases gastric epithelial susceptibility to apoptosis.

IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis

Importance of gastrin in the pathogenesis and treatment of gastric tumors

Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.

In Reply to Habr-Gama et al

Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium

Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling.

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

Intestinal Preparation Techniques for Histological Analysis in the Mouse.

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice

Letter: gastric cancer and pernicious anaemia--only a minority of UK pernicious anaemia patients have had a gastroscopy

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance.

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.

Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice

Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis

Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis

Oral iron exacerbates colitis and influences the intestinal microbiome

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation

Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1.

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1.

Peptide receptor radionuclide therapy with (90)Y-DOTATATE/(90)Y-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity

Potential clinical indications for a CCK2 receptor antagonist

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice

Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo.

Progastrin stimulates murine colonic epithelial mitosis after DNA damage

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS).

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest.

Review article: How useful are the rodent animal models of gastric adenocarcinoma?

Review article: Pathogenesis and management of gastric carcinoid tumours.

Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality.

Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice.

Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice