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List of works by Hiroyuki Seimiya

2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation

scientific article published on 01 March 1998

A caged ligand for a telomeric G-quadruplex.

scientific article

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor

scientific article published on 7 March 2010

ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer

scientific article published on 11 February 2020

APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.

scientific article published on 8 February 2017

ASK1 mediates apoptotic cell death induced by genotoxic stress.

scientific article published on January 1999

ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

scientific article

Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells.

scientific article

Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B

scientific article published in Scientific Reports

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

scientific article published in Scientific Reports

Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation

scientific article published on 25 May 2015

Cross-species difference in telomeric function of tankyrase 1.

scientific article published on 13 April 2007

Crossroads of telomere biology and anticancer drug discovery

scientific article published on 24 June 2020

Design and synthesis of a berberine dimer: a fluorescent ligand with high affinity towards G-quadruplexes

scientific article

Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.

scientific article published on 4 January 2013

Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines

scientific article published on 01 January 1995

Differential expression of protein tyrosine phosphatase genes during phorbol ester-induced differentiation of human leukemia U937 cells

scientific article published on 01 December 1993

Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib

scientific article published on 27 January 2020

Epithelial-mesenchymal transition promotes SOX2 and NANOG expression in bladder cancer.

scientific article published on 27 February 2017

Evaluation of tankyrase inhibition in whole cells

scientific article published on 01 January 2007

Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand.

scientific article published on 12 April 2013

Expression of mutant RPA in human cancer cells causes telomere shortening

scientific article

FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis.

scientific article published on August 1999

Fission Yeast Pot1 and RecQ Helicase Are Required for Efficient Chromosome Segregation

Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation ⬇️

scientific article published on November 22, 2010

From the wings to the center stage of chromosomes

scientific article published on 01 November 2019

Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells

scientific article published in August 1998

Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation

scientific article

G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

scientific article

G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells

scientific article published on February 2016

G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression

scientific article published on 08 December 2020

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.

scientific article

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

scientific article

HnRNP A3 binds to and protects mammalian telomeric repeats in vitro.

scientific article

Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.

scientific article

Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact

scientific article

Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells

scientific article published on 18 December 2013

Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase

scientific article published on 01 September 1995

Involvement of 14-3-3 proteins in nuclear localization of telomerase

scientific article

Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells

scientific journal article

M-CSF gene transduction in multidrug-resistant human cancer cells to enhance anti-P-glycoprotein antibody-dependent macrophage-mediated cytotoxicity

scientific article published in July 1993

Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein.

scientific article

Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth.

scientific article

Phorbol ester-resistant monoblastoid leukemia cells with a functional mitogen-activated protein kinase cascade but without responsive protein tyrosine phosphatases.

scientific article

Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells

scientific article (publication date: June 2001)

Predicting Risk at the End of the End: Telomere G-tail as a Biomarker

scientific article

Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.

scientific article published on 22 September 2008

RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.

scientific article published on 20 October 2018

Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs

scientific article

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture

scientific article

Revisiting Telomere Shortening in Cancer

scientific article published on 31 January 2019

Senescence from glioma stem cell differentiation promotes tumor growth

scientific article published on 14 January 2016

Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer

scientific article

TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.

scientific article

TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression

scientific article published on 16 February 2010

TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival by regulation of endoplasmic reticulum chaperone expression

scientific article

Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.

scientific article

Tankyrase Inhibitors Target Colorectal Cancer Stem Cells via AXIN-Dependent Downregulation of c-KIT Tyrosine Kinase

scientific article published on 06 January 2020

Tankyrase promotes primary precursor miRNA processing to precursor miRNA

scientific article published on 03 December 2019

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation ⬇️

scientific article published on August 5, 2011

Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion

scientific article published on 15 February 2017

Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization

scientific article published on 08 October 2020

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

scientific article

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

scientific article

Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins

scientific article published on 01 August 1998

Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation

scientific article

Telomere length influences cancer cell differentiation in vivo.

scientific article published on 28 May 2013

Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.

scientific article published in July 2002

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo

scientific article

Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.

scientific article published on 09 January 2012

The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma

scientific article published on 2 November 2015

The eleventh Korea-Japan-Germany joint symposium on cancer and ageing research.

scientific article published on 28 February 2013

The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)

scientific article

Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole

scientific article published on 22 April 2010

[Cancer therapy by PARP inhibitors]

scientific article published on 01 August 2015

[Involvement of PTP-U2 in terminal differentiation and apoptosis of leukemia cells]

scientific article published on 01 June 1998

[Telomerase downregulation during differentiation of leukemia cells]

scientific article published on 01 May 1998

c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

scientific article published on 01 February 1997

cDNA expression cloning of the 85-kDa protein overexpressed in adriamycin-resistant cells

scientific article published in April 1993

mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.

scientific article

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