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List of works by Assam El-osta

A pipeline for the identification and characterization of chromatin modifications derived from ChIP-Seq datasets

scientific article published on 13 June 2012

Absolute quantitation of MDR1 transcripts using heterologous DNA standards--validation of the competitive RT-PCR (CRT-PCR) approach

scientific article published in June 1999

Age-Related Differential Structural and Transcriptomic Responses in the Hypertensive Heart

scientific article published on 09 July 2018

Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons

scientific article published in January 2010

Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance.

scientific article

Analysis of Chromatin-Immunopurified MeCP2-Associated Fragments ⬇️

scientific article published on December 7, 2001

Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders

scientific article

Analysis of the barley leaf transcriptome under salinity stress using mRNA-Seq

article

Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy

scientific article

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

scientific article

Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities

article

Cardiac ventricular chambers are epigenetically distinguishable

scientific article published in February 2010

Chinese Famine and the diabetes mellitus epidemic

scientific article published on 01 February 2020

Chromatin Modifications Associated with Diabetes ⬇️

scientific article published on May 26, 2012

Chromatin context and ncRNA highlight targets of MeCP2 in brain

scientific article published on 30 October 2013

Chromatin modifications remodel cardiac gene expression

scientific article published on 08 May 2014

Chromatin modifying agents - the cutting edge of anticancer therapy

scientific article published on 01 June 2011

Clinical applicability of methylome sequencing in a pilot study of ischemic stroke individuals

Clonogenic assay: adherent cells

scientific article

Contemporary Trends Emerging in Epigenomics and Metabolism

scientific article published on 22 June 2018

Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1

scientific article

Current Advances in Noncoding RNA Relevant to Epigenetic Mechanisms

Current perspectives in Set7 mediated stem cell differentiation.

scientific article

DNA damage detection and repair, and the involvement of epigenetic states.

scientific article

DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus

scientific article published on 25 April 2016

DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.

scientific article published on November 2003

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

scientific article

Deep sequencing reveals novel Set7 networks.

scientific article published on 30 May 2014

Development of novel activin-targeted therapeutics

scientific article

Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring

scientific article published on 07 June 2018

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments.

scientific article published on 8 January 2007

Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells

scientific article

Double-strand breaks and the concept of short- and long-term epigenetic memory.

scientific article published on 21 December 2010

Double-strand breaks: signaling pathways and repair mechanisms.

scientific article published in September 2004

Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain.

scientific article

Dynamic changes in the cardiac methylome during postnatal development

scientific article published on 9 December 2014

Effects of the Histone Deacetylase Inhibitor, Trichostatin A, in a Chronic Allergic Airways Disease Model in Mice

article

Endothelial Transcriptome in Response to Pharmacological Methyltransferase Inhibition

article

Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine

article

Epigenetic Changes in Diabetes and Cardiovascular Risk.

scientific article published on May 2016

Epigenetic Modification of the Norepinephrine Transporter Gene in Postural Tachycardia Syndrome

article

Epigenetic and Genetic Mechanisms of Abnormal 11p15 Genomic Imprinting in Silver-Russell and Beckwith-Wiedemann Syndromes

scientific article published on 01 January 2011

Epigenetic changes activate widespread signals in response to double-strand breaks.

scientific article published on 9 July 2004

Epigenetic changes in diabetes.

scientific article published on 11 March 2013

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

scientific article published on December 2005

Epigenetic evidence of an Ac/Dc axis by VPA and SAHA

scientific article published on 20 March 2021

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

scientific article published on 26 June 2012

Epigenetic phenomena linked to diabetic complications.

scientific article

Epigenetic programming, early life nutrition and the risk of metabolic disease.

scientific article published on 5 September 2017

Epigenetic regulation and fetal programming.

scientific article published on February 2008

Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing

scientific article published on 01 January 2010

Epigenetic-mediated reprogramming of pancreatic endocrine cells.

scientific article

Epigenetics and metabolism.

scientific article

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena.

scientific article published on 23 October 2017

Epigenetics in diabetic nephropathy, immunity and metabolism.

scientific article published on 11 November 2017

Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome.

scientific article published on 23 June 2016

Etiology matters - Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy.

scientific article

Evaluation of genomic methylation indices in juvenile myoclonic epilepsy

scientific article published on 01 May 2019

Evaluation of microRNA alignment techniques.

scientific article published on 9 June 2016

Evaluation of the spatial distribution of gammaH2AX following ionizing radiation

scientific article published on 7 August 2010

Expression of mdr1 and mrp in the normal B-cell homologue of B-cell chronic lymphocytic leukaemia

scientific article published on 01 March 1997

FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle

scientific article published in 2009

Galectin-3 deficiency ameliorates fibrosis and remodelling in dilated cardiomyopathy mice with enhanced Mst1 signaling

scientific article published on 02 November 2018

GammaH2AX as a molecular marker of aging and disease.

scientific article published on February 2010

Gene name errors are widespread in the scientific literature

scientific article

Genetic and epigenetic events in diabetic wound healing ⬇️

scientific article published on December 16, 2010

Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes

scientific article

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy

scientific article

Genetic variants within the second intron of the KCNQ1 gene affect CTCF binding and confer a risk of Beckwith-Wiedemann syndrome upon maternal transmission.

scientific article published on 4 July 2014

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

scientific article

Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasia

scientific article published on 10 May 2019

Glycemic Memories and the Epigenetic Component of Diabetic Nephropathy ⬇️

scientific article published on August 1, 2013

Glycemic memory ⬇️

scientific article published on February 1, 2012

HDAC Inhibition in Vascular Endothelial Cells Regulates the Expression of ncRNAs.

scientific article published on 25 May 2016

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

scientific article

Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

scientific article published on 19 June 2019

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

scientific article

Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes

Histone modifications regulate the norepinephrine transporter gene

scientific article published on 15 November 2010

Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder

scientific article

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

scientific article published on 10 February 2009

Immunomodulatory effects of histone deacetylase inhibitors

scientific article published on May 2013

Improving understanding of chromatin regulatory proteins and potential implications for drug discovery

scientific article published on 27 February 2016

Influence of natural and synthetic histone deacetylase inhibitors on chromatin

scientific article published on 09 February 2012

Interplay of chromatin modifications and non-coding RNAs in the heart

scientific article published on 10 October 2013

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis

scientific article

Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

scientific article

Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.

scientific article published on 28 February 2018

MDR1, chemotherapy and chromatin remodeling.

scientific article published on 23 September 2004

MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines.

scientific article

Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative phosphorylation in adult male rat offspring.

scientific article published on 31 December 2013

MeCP2 interacts with chromosomal microRNAs in brain

scientific article published in January 2017

Metabolic Karma-The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award Lecture

scientific article published on 01 May 2018

Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms

scientific article published on 27 April 2010

Metabolism and chromatin dynamics in health and disease

scientific article

Metaboloepigenetics in cancer, immunity, and cardiovascular disease

scientific article published in 2022

Methylation of the SLC6a2 gene promoter in major depression and panic disorder

scientific article

Microparticles: major transport vehicles for distinct microRNAs in circulation

scientific article published on 18 January 2012

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.

scientific article

Molecular model of naphthalene-induced DNA damage in the murine lung

article

Multi-Cellular Transcriptional Analysis of Mammalian Heart Regeneration ⬇️

scientific article

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

scientific article published on 05 April 2013

NET silencing by let-7i in postural tachycardia syndrome

scientific article published on 23 March 2017

New insights into the pathogenesis of Beckwith-Wiedemann and Silver-Russell syndromes: contribution of small copy number variations to 11p15 imprinting defects

scientific article published on 8 September 2011

Non-referenced genome assembly from epigenomic short-read data

scientific article

On the use of DNA methylation inhibitors and the reversal of transcriptional silencing.

scientific article

Pathological hypertrophy reverses β2-adrenergic receptor-induced angiogenesis in mouse heart

scientific article published on March 2015

Pharmacological Histone Deacetylation Distinguishes Transcriptional Regulators.

scientific article published on 4 November 2016

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

scientific article published on 19 September 2016

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

scientific article

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation

scientific article

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease

article

Quantification of gammaH2AX foci in response to ionising radiation.

scientific article

Quantitation of gammaH2AX foci in tissue samples

scientific article

RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis

scientific article published on 15 February 2018

RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells

scientific article published on 26 June 2015

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat)

scientific article

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

scientific article published on 29 December 2015

Redox Mediating Epigenetic Changes Confer Metabolic Memories ⬇️

scientific article published on July 20, 2012

Regulation of MDR1 gene expression: emerging concepts.

scientific article

Remodeling is at the heart of chromatin: the heartaches of chromatin

scientific article

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression

scientific article

Sequential extraction of DNA and DNA-binding proteins from low cell numbers.

scientific article published on April 1997

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells.

scientific article published on 20 July 2016

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

scientific article

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes.

scientific article published on 8 September 2017

The circadian syndrome predicts cardiovascular disease better than metabolic syndrome in Chinese adults

scientific article published on 19 December 2020

The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy.

scientific article published on 04 April 2009

The epigenetic contribution to the development and progression of vascular diabetic complications

scientific article

The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X.

scientific article published on 16 July 2005

The neuronal noradrenaline transporter, anxiety and cardiovascular disease

scientific article (publication date: July 2006)

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.

scientific article

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

scientific journal article

The rise and fall of genomic methylation in cancer.

scientific article published on February 2004

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer.

scientific article published on November 2003

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.

scientific article published on 27 February 2018

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

scientific article published on 22 September 2008

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

scientific article published in October 2008

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes.

scientific article

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation

scientific journal article

Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease.

scientific article published on 23 September 2004

Vascular histone deacetylation by pharmacological HDAC inhibition

scientific article

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

scientific article published on 17 May 2021

gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci

scientific article published on 27 October 2009

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