List of works - Tomas Bjorklund

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System ⬇️

scientific article published on September 24, 2010

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

scientific article published in July 2018

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

scientific article

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP ⬇️

scientific article published on April 30, 2013

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

scientific article published on 09 December 2019

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

scientific article

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level

scientific article

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

scientific article published on 13 October 2017

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

scientific article published on 04 May 2016

Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease

scientific article

Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates

scientific article

Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons.

scientific article

Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

scientific article published on January 2016

Gene therapy for Parkinson's disease

scientific article published on 01 January 2010

Gene therapy for dopamine replacement.

scientific article published on January 2010

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease

scientific article

Imaging in cell-based therapy for neurodegenerative diseases.

scientific article

In vivo gene delivery for development of mammalian models for Parkinson's disease.

scientific article published on 22 September 2007

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain

scientific article

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing.

scientific article published on 31 January 2018

Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

scientific article published in January 2006

Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits ⬇️

scientific article published on April 6, 2011

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons

scientific article

Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

scientific article published on 17 August 2009

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

scientific article

Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain

scientific article published on 01 January 2019

Repairing the Brain: Gene Therapy

article

Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.

scientific article

List of works by Tomas Bjorklund

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System ⬇️

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP ⬇️

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease

Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates

Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons.

Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

Gene therapy for Parkinson's disease

Gene therapy for dopamine replacement.

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease

Imaging in cell-based therapy for neurodegenerative diseases.

In vivo gene delivery for development of mammalian models for Parkinson's disease.

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing.

Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits ⬇️

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons

Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain

Repairing the Brain: Gene Therapy

Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.