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List of works by Mark S. Dillingham

A Single-Molecule Approach to Visualize the Unwinding Activity of DNA Helicases

scientific article published on 01 January 2011

A dual-nuclease mechanism for DNA break processing by AddAB-type helicase-nucleases

scientific article

A molecular throttle: the recombination hotspot chi controls DNA translocation by the RecBCD helicase

scientific article (publication date: 5 September 2003)

A new method for inferring hidden markov models from noisy time sequences

scientific article

A step backward in advancing DNA replication: rescue of stalled replication forks by RecG.

scientific article published in October 2001

AFM volumetric methods for the characterization of proteins and nucleic acids ⬇️

scientific article published on February 28, 2013

Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control

scientific article

An iron-sulfur cluster is essential for the binding of broken DNA by AddAB-type helicase-nucleases

scientific article published on 7 January 2009

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

scientific article published on 19 July 2021

Bipolar DNA translocation contributes to highly processive DNA unwinding by RecBCD enzyme

scientific article

Bulk and single-molecule analysis of a bacterial DNA2-like helicase-nuclease reveals a single-stranded DNA looping motor

scientific article published on 04 July 2020

Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination

scientific article

Crystal structure of RecBCD : a machine for processing DNA breaks

Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks

scientific article

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

scientific article

CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

scientific article published on 02 January 2019

DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase

scientific article

Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed

scientific article

Direct measurement of single-stranded DNA translocation by PcrA helicase using the fluorescent base analogue 2-aminopurine

scientific article

Directional Loading and Stimulation of PcrA Helicase by the Replication Initiator Protein RepD

scientific article published on 24 May 2007

Engineering a reagentless biosensor for single-stranded DNA to measure real-time helicase activity in Bacillus

scientific article published on 11 June 2014

Escherichia coli ribosomal protein L3 stimulates the helicase activity of the Bacillus stearothermophilus PcrA helicase.

scientific article published on May 1998

Fluorescent single-stranded DNA binding protein as a probe for sensitive, real-time assays of helicase activity

scientific article published on 3 July 2008

Force determination in lateral magnetic tweezers combined with TIRF microscopy.

scientific article

Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

scientific article published in 2022

How to Build a DNA Unwinding Machine ⬇️

scientific article published on July 3, 2012

Human CtIP forms a tetrameric dumbbell-shaped particle which binds and bridges complex DNA end structures for double-strand break repair

Inhibiting translation elongation can aid genome duplication in Escherichia coli

scientific article published on 11 December 2016

Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex

scientific article

Iron–sulphur clusters in nucleic acid processing enzymes ⬇️

scientific article published on December 12, 2011

Molecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, χ, by RecBCD enzyme

scientific article

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD.

scientific article

On the mechanism of recombination hotspot scanning during double-stranded DNA break resection

scientific article

ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements

ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements

scientific article published on 25 March 2019

Probing DNA helicase kinetics with temperature-controlled magnetic tweezers

scientific article published on 14 November 2014

Protein modification for single molecule fluorescence microscopy

scientific article published on 14 July 2008

RecBCD enzyme and the repair of double-stranded DNA breaks

scientific article

RecBCD enzyme is a bipolar DNA helicase

scientific article

Recombination Hotspots and Single-Stranded DNA Binding Proteins Couple DNA Translocation to DNA Unwinding by the AddAB Helicase-Nuclease

scientific article published on 01 June 2011

Recombination hotspots attenuate the coupled ATPase and translocase activities of an AddAB-type helicase-nuclease

scientific article

Rep provides a second motor at the replisome to promote duplication of protein-bound DNA.

scientific article

Repercussions of DNA tracking by the type IC restriction endonuclease EcoR124I on linear, circular and catenated substrates.

scientific article

Replicative Helicases: A Staircase with a Twist

scientific article published on 01 October 2006

Single molecule approaches to monitor the recognition and resection of double-stranded DNA breaks during homologous recombination

scientific article published on 23 February 2014

Site-directed mutagenesis of motif III in PcrA helicase reveals a role in coupling ATP hydrolysis to strand separation.

scientific article published on August 1999

Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation

scientific article published on 8 January 2015

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

scientific article published on 23 December 2016

Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites

scientific article

Structure and mechanism of helicases and nucleic acid translocases

scientific article (publication date: 2007)

Superfamily 1 helicases .

scientific article published on January 2013

Superfamily I helicases as modular components of DNA-processing machines ⬇️

scientific article published on April 1, 2011

The 2B subdomain of Rep helicase links translocation along DNA with protein displacement

The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain

scientific article

The AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation.

scientific article published on 21 April 2006

The conflict between DNA replication and transcription ⬇️

scientific article published on May 31, 2012

The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase

scientific article

The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA

scientific article published in Journal of Biological Chemistry

The processing of double-stranded DNA breaks for recombinational repair by helicase-nuclease complexes

scientific article published on 29 January 2010

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere ⬇️

scientific article published on 15 December 2017

The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase

scientific article published on 4 February 2017

The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair

scientific article

Translocation by the RecB motor is an absolute requirement for {chi}-recognition and RecA protein loading by RecBCD enzyme

scientific article

Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.

scientific article published in July 2000

Using DNA as a fiducial marker to study SMC complex interactions with the atomic force microscope

scientific article

Visualizing helicases unwinding DNA at the single molecule level

scientific article

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