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List of works by Alexandra Spencer

4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques

scientific article

A Multi-Filovirus Vaccine Candidate: Co-Expression of Ebola, Sudan, and Marburg Antigens in a Single Vector

scientific article published on 21 May 2020

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys

scientific article

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

scientific article

A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity

scientific article (publication date: 2012)

An in vitro assay to measure antibody-mediated inhibition of P. berghei sporozoite invasion against P. falciparum antigens.

scientific article published on 5 December 2017

Assessment of the Plasmodium falciparum Preerythrocytic Antigen UIS3 as a Potential Candidate for a Malaria Vaccine

scientific article published on 28 December 2016

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

scientific article published on 30 July 2020

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

scientific article published on 13 October 2016

Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

scientific article published on 30 October 2017

Comment on "CRTAM Confers Late-Stage Activation of CD8+ T Cells to Regulate Retention within Lymph Node"

scientific article published on 01 April 2010

Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates

scientific article published on 3 July 2015

Correction: Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia virus Ankara (MVA).

scientific article

Deletion of Fifteen Open Reading Frames from Modified Vaccinia Virus Ankara Fails to Improve Immunogenicity

scientific article published on 8 June 2015

Development of a Molecular Adjuvant to Enhance Antigen-Specific CD8 T Cell Responses

scientific article published in Scientific Reports

Development of an in vitro assay and demonstration of Plasmodium berghei liver-stage inhibition by TRAP-specific CD8+ T cells

scientific article

Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in mice

scientific article

Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain

scientific article

Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines

scientific article published on 22 November 2010

Enhancing cellular immunogenicity of MVA-vectored vaccines by utilizing the F11L endogenous promoter

scientific article published on 23 November 2015

Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines

scientific article

Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates

scientific article (publication date: 2012)

Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice

scientific article published on 11 December 2015

Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1.

scientific article published on January 2013

Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley fever vaccine in mice

scientific article

Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass

scientific article published in February 2010

Malaria vaccines: identifying Plasmodium falciparum liver-stage targets

scientific article

Modification of Adenovirus vaccine vector-induced immune responses by expression of a signalling molecule

scientific article published on 31 March 2020

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe

scientific article

Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

scientific article published on 23 August 2011

Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors

scientific article (publication date: 2012)

Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria

scientific article published on 22 January 2020

Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans

scientific article

Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection

scientific article

Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA).

scientific article

Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults

scientific article

Simian adenoviruses as vaccine vectors.

scientific article published on 15 September 2016

T-cell responses in children to internal influenza antigens, 1 year after immunization with pandemic H1N1 influenza vaccine, and response to revaccination with seasonal trivalent-inactivated influenza vaccine

scientific article

The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8+ T Cells Present in the Liver

scientific article published on 13 January 2017

The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species

scientific article

Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations

scientific article

Viral vectors as vaccine platforms: from immunogenicity to impact

scientific article

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