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List of works by Edward R O'Brien

17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats

scientific article published on 18 November 2004

A citywide protocol for primary PCI in ST-segment elevation myocardial infarction

scientific article

A novel stretching platform for applications in cell and tissue mechanobiology.

scientific article

Abundance of Plaque Microvessels is Associated With Constrictive Remodeling in Angioplastied Human Coronary Arteries

scientific article published on 01 May 2001

Antagonism of the alpha4 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation

scientific article published on 12 March 2004

Arterial expression of the plasminogen activator system early after cardiac transplantation

scientific article published on 01 August 1997

Arterial wall neovascularization--potential role in atherosclerosis and restenosis.

scientific article published on November 1997

Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8β-VE2

scientific article published on 01 October 2011

Bivalirudin for primary percutaneous coronary interventions: outcome assessment in the Ottawa STEMI registry

scientific article published on 13 November 2012

Cardiovascular complications of Salmonella enteritidis infection.

scientific article published on October 2010

Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions

scientific article

Circulating endothelial progenitor cell levels are not reduced in HIV-infected men.

scientific article published on 11 January 2012

Circulating endothelial progenitor cells and in-stent restenosis: friend, foe, or none of the above?

scientific article

Circulating endothelial progenitor cells in HIV infection: a systematic review.

scientific article published on 08 February 2013

Clinical outcomes among patients with extreme obesity undergoing elective coronary revascularization: Evaluation of major complications in contemporary practice.

scientific article published on 18 March 2015

Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study)

scientific article (publication date: 2 August 2005)

Comparison of Early Mortality of Paramedic-Diagnosed ST-Segment Elevation Myocardial Infarction With Immediate Transport to a Designated Primary Percutaneous Coronary Intervention Center to That of Similar Patients Transported to the Nearest Hospital

article

Comparison of processing and sectioning methodologies for arteries containing metallic stents

scientific article published on 23 January 2006

Contribution of recipient-derived cells in allograft neointima formation and the response to stent implantation

scientific article (publication date: 2008)

Coronary stent fracture.

scientific article

Current understanding of in-stent restenosis and the potential benefit of drug eluting stents.

scientific article published on March 2004

Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3beta inhibitor

scientific article published on 17 February 2010

Detection of Chlamydia pneumoniae TWAR in human coronary atherectomy tissues.

scientific article published on August 1995

Discovery of NM23-H2 as an estrogen receptor β-associated protein: Role in estrogen-induced gene transcription and cell migration

article

Establishing an approach for patients with recent coronary occlusion: Identification of viable myocardium

scientific article published on 01 May 1999

Evaluation of myocardial perfusion using rubidium-82 positron emission tomography after myocardial infarction in patients receiving primary stent implantation or thrombolytic therapy

scientific article published on 01 October 2001

Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages.

scientific article

Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

scientific article

Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

scientific article published on 19 June 2008

Gene dosage of the common variant 9p21 predicts severity of coronary artery disease

scientific article published in August 2010

Giant saphenous vein graft aneurysm presenting as ST-elevation myocardial infarction

scientific article published on 27 November 2013

Glycogen synthase kinase-3β inhibition augments diabetic endothelial progenitor cell abundance and functionality via cathepsin B: a novel therapeutic opportunity for arterial repair

scientific article published on 2 December 2013

Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial

scientific article

Heat shock protein 27 attenuates neointima formation and accelerates reendothelialization after arterial injury and stent implantation: importance of vascular endothelial growth factor up-regulation.

scientific article

Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

scientific article published on 3 September 2009

Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE-/- mice

scientific article

Heat shock protein 27: clue to understanding estrogen-mediated atheroprotection?

scientific article published on February 2010

Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

scientific article

Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling

scientific article published on 11 August 2013

Hospitalization costs of primary stenting versus thrombolysis in acute myocardial infarction: cost analysis of the Canadian STAT Study

scientific article published on 3 November 2003

Impact of Center Experience on Patient Radiation Exposure During Transradial Coronary Angiography and Percutaneous Intervention: A Patient-Level, International, Collaborative, Multi-Center Analysis

scientific article published on 31 May 2016

Infective Endocarditis Presenting as ST-Elevation Myocardial Infarction: An Angiographic Diagnosis

scientific article published on 03 March 2012

Inhibition of endothelial progenitor cell glycogen synthase kinase-3beta results in attenuated neointima formation and enhanced re-endothelialization after arterial injury.

scientific article

Involvement of Progenitor Cells in Vascular Repair ⬇️

scientific article published on November 1, 2003

Late clinical and angiographic follow-up after stenting in evolving and recent myocardial infarction

scientific article published on 01 April 1998

Letter by Hibbert et al regarding article, "Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice".

scientific article published in April 2008

NM23-H2, an estrogen receptor β-associated protein, shows diminished expression with progression of atherosclerosis

scientific article published on 03 August 2006

Natural history and management of aortocoronary saphenous vein graft aneurysms: a systematic review of published cases.

scientific article published on October 2012

Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention

scientific article published on 21 February 2013

Percutaneous coronary intervention with or without on-site coronary artery bypass surgery: a systematic review and meta-analysis

scientific article published on 10 January 2012

Pre-procedural atorvastatin mobilizes endothelial progenitor cells: clues to the salutary effects of statins on healing of stented human arteries

scientific article

Pulmonary hypertension

scientific article published on 01 May 2010

RACER renal stents for large diameter left main coronary artery intervention

scientific article published on 16 September 2011

Recombinant heat shock protein 27 (HSP27/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells.

scientific article published on 24 March 2017

Reduction in mortality as a result of direct transport from the field to a receiving center for primary percutaneous coronary intervention

scientific article

Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats

scientific article published on 2 February 2006

Replication in restenotic atherectomy tissue

scientific article published on 01 September 2000

Response to Letter Regarding Article, “Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry”

scientific article published on 01 April 2013

Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

scientific article published on 3 February 2015

Serum heat shock protein 27 levels represent a potential therapeutic target for atherosclerosis: observations from a human cohort and treatment of female mice.

scientific article published on 10 June 2013

Sex differences in COVID-19 mortality: opportunity to develop HSP27 (HSPB1) immunotherapy to treat hyper-inflammation?

scientific article published on 06 August 2020

Stenting versus thrombolysis in acute myocardial infarction trial (STAT)

article

The Heat Shock Protein 27 Immune Complex Enhances Exosomal Cholesterol Efflux

scientific article published on 17 August 2020

The effects of knockdown of rho-associated kinase 1 and zipper-interacting protein kinase on gene expression and function in cultured human arterial smooth muscle cells

scientific article published on 27 February 2015

The evolution of coronary stents: a brief review

scientific article

The importance of thrombus organization and stellate cell phenotype in collagen I gene expression in human, coronary atherosclerotic and restenotic lesions

scientific article published on 01 September 1996

The interaction and cellular localization of HSP27 and ERβ are modulated by 17β-estradiol and HSP27 phosphorylation

article

Time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries

scientific article published on 01 January 1999

Transbrachial insertion of an intra-aortic balloon pump for high-risk percutaneous coronary intervention

scientific article published on 03 May 2012

Transradial Versus Transfemoral Artery Approach for Coronary Angiography and Percutaneous Coronary Intervention in the Extremely Obese

scientific article published on 01 August 2012

Unprotected left main coronary artery stenting with zotarolimus (Endeavor) drug-eluting stents: a single center retrospective experience

scientific article published on 10 January 2012

Update on the biology and clinical study of restenosis.

scientific article published on July 1994

Usefulness of Intracoronary Stenting in Acute Myocardial Infarction

scientific article published on 01 July 1996

Usefulness of mean platelet volume as a biomarker for long-term outcomes after percutaneous coronary intervention.

scientific article

c-kit-immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions

scientific article published in August 2004

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