List of works - Stefania Meini

A different molecular interaction of bradykinin and the synthetic agonist FR190997 with the human B2 receptor: evidence from mutational analysis

scientific article published on 26 August 2003

A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers

scientific article published in February 1999

Agonist Activity at the Kinin B1 Receptor: Structural Requirements of the Central Tetrapeptide

scientific article published on 01 January 2001

Ala scan analogues of HOE 140. Synthesis and biological activities

scientific article published in November 2000

Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation

scientific article

Antagonist profile of ibodutant at the tachykinin NK(2) receptor in guinea pig isolated bronchi

scientific article

Arachidonic acid-induced bronchomotor responses are partially mediated by release of sensory neuropeptides from capsaicin-sensitive structures.

scientific article published on December 1989

Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant

scientific article published in September 2013

Bradykinin B2 and GPR100 receptors: a paradigm for receptor signal transduction pharmacology

scientific article published on 15 November 2004

Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus.

scientific article

Bradykinin and B2 receptor antagonism in rat and human articular chondrocytes ⬇️

scientific article published on February 1, 2011

Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers.

scientific article published on 28 February 2006

Calcitonin gene related peptide as inhibitory neurotransmitter in the ureter.

scientific article published on July 1995

Capsaicin desensitization selectively inhibits lipoxin A4-induced contraction in guinea pig bronchus

scientific article

Capsaicin pretreatment does not alter rat urinary bladder motor responses induced by a kinin B1 receptor agonist after endotoxin treatment

article

Cardiovascular effects of peptide kinin B2 receptor antagonists in rats

scientific article published in April 2002

Characterization of bradykinin B(2) receptor antagonists in human and rat urinary bladder

scientific article

Characterization of ibodutant at NK(2) receptor in human colon.

scientific article published on 29 January 2013

Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

scientific article published on 18 December 2006

Characterization of the tachykinin NK2 receptor in the human bronchus: influence of amastatin-sensitive metabolic pathways

scientific article published in February 1994

Cinnamic acids and mono-substituted benzoic acids as useful capping groups for the preparation of hNK2 receptor antagonists

scientific article

Comparative antagonist pharmacology at the native mouse bradykinin B2 receptor: radioligand binding and smooth muscle contractility studies.

scientific article published on 18 December 2006

Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon.

scientific article published on May 1994

Contractile effect of endothelin on isolated iris sphincter muscle of the pig.

scientific article published in September 1989

Design and synthesis of novel sulfonamide-containing bradykinin hB(2) receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine.

scientific article

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides

scientific article published in June 2006

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 2. Synthesis and structure-activity relationships of alpha,alpha-cycloalkylglycine sulfonamides.

scientific article published in February 2007

Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized Guinea pigs.

scientific article

Differences in electromechanical coupling between bradykinin and the nonpeptide kinin B2 receptor agonist, FR 190997, in the circular muscle of guinea-pig colon.

scientific article

Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists

scientific article published on 12 September 2007

Effect of dexamethasone on cyclophosphamide-induced cystitis in rats: lack of relation with bradykinin B1 receptor-mediated motor responses

scientific article

Effect of iloprost on plasma asymmetric dimethylarginine and plasma and platelet serotonin in patients with peripheral arterial occlusive disease

scientific article published on 18 July 2006

Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum

scientific article published in February 1994

Effects of capsaicin, tachykinins, calcitonin gene-related peptide and bradykinin in the pig iris sphincter muscle

article

Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation.

scientific article published on August 1994

Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum

scientific article published in April 1993

Exploring the binding ability of phenanthroline-based polyammonium receptors for anions: hints for design of selective chemosensors for nucleotides.

scientific article published in October 2009

Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease.

scientific article

Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes

scientific article published on 26 May 2012

GR 73,632 and [Glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder.

scientific article

Iloprost treatment reduces TNF-alpha production and TNF-RII expression in critical limb ischemia patients without affecting IL6.

scientific article published in November 2005

In vitro and in vivo activity of analogues of the kinin B2 receptor antagonist MEN1 1270.

scientific article published in April 2002

In vivo effects of neurokinin B on rat urinary bladder motility: Involvement of tachykinin NK1 and NK2 receptors

scientific article published on 01 July 1994

In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon

scientific article published on 01 May 1996

Inflammation modifies the role of cyclooxygenases in the contractile responses of the rat detrusor smooth muscle to kinin agonists.

scientific article

Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor

scientific article published in August 2002

Interactions between sensory neuropeptides and lipid mediators in the airways.

scientific article

Isbufylline, a xanthine derivative, inhibits bronchoconstrictor responses produced by stimulation of capsaicin-sensitive sensory nerves in guinea-pig: 'In vitro' and 'in vivo' evidence.

scientific article published in December 1993

Kinin B1 receptor-mediated motor responses in normal or inflamed rat urinary bladder in vivo

scientific article published in March 1999

Knee osteoarthritis: a role for bradykinin?

scientific article published on August 2008

Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor

scientific article published on 10 July 2014

MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors.

scientific article published in December 1994

MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist

scientific article published on 26 August 2006

MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.

scientific article published in December 2005

MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs

scientific article published on 18 July 2005

Modulation on C- and N-terminal moieties of a series of potent and selective linear tachykinin NK(2) receptor antagonists

scientific article published in January 2010

Monocyclic human tachykinin NK-2 receptor antagonists as evolution of a potent bicyclic antagonist: QSAR and site-directed mutagenesis studies

scientific article published on 01 August 2002

Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 rec

scientific article

Mutagenesis at the human tachykinin NK(2) receptor to define the binding site of a novel class of antagonists

scientific article published in March 2004

New conformationally homogeneous beta-turn antagonists of the human B2 kinin receptor

scientific article

New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide

scientific article

New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide

scientific article published on 25 March 2013

Nitric oxide is the mediator of tachykinin NK3 receptor-induced relaxation in the circular muscle of the guinea-pig ileum

scientific article published on 01 August 1993

Nociceptin and the micturition reflex.

scientific article

Nonpeptide antagonists for kinin receptors.

scientific article

Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts

scientific article published on December 2009

Peptide and non-peptide bradykinin B2 receptor agonists and antagonists: a reappraisal of their pharmacology in the guinea-pig ileum

scientific article published in December 2000

Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions

scientific article

Pharmacologic and neurochemical evidence for the activation of capsaicin-sensitive sensory nerves by lipoxin A4 in guinea pig bronchus.

scientific article

Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.

scientific article published on February 1995

Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.

scientific article published on 13 May 2009

Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells

scientific article published in September 2004

Pharmacological profile of the novel mammalian tachykinin, hemokinin 1

scientific article

Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor

scientific article published in June 2005

Preliminary mutational analysis of the human kinin B2 receptor for nonpeptide antagonist ligands recognition

scientific article published in April 2002

Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).

scientific article published in January 1995

Rechargeability of Li–air cathodes pre-filled with discharge products using an ether-based electrolyte solution: implications for cycle-life of Li–air cells

scientific article published on 10 June 2013

Short-term and long-term effects of one-week treatment with intravenous iloprost in critical limb ischemia patients (Leriche-Fontaine stage III and IV).

scientific article published in March 2005

Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists

scientific article published in February 2004

Stability of superoxide radicals in glyme solvents for non-aqueous Li-O2 battery electrolytes

scientific article published on 13 June 2013

Structure-activity relationships of 6-methyl-benzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]cyclopentyl)amide, potent antagonist of the neurokinin-2 receptor

scientific article

Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis

scientific article

Tachykinin NK1 receptor subtypes in the rat urinary bladder.

scientific article published on March 1994

Tachykinin control of ferret airways: Mucus secretion, bronchoconstriction and receptor mapping

scientific article published on 01 February 1993

Tachykinin receptor assays.

scientific article

Tachykinin receptors and intestinal motility

scientific article published on June 1, 1997

Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo

scientific article

Takayasu’s Arteritis

scientific article published on 01 October 2006

The N-terminal of icatibant and bradykinin interact with the same Asp residues in the human B2 receptor

scientific article

The effect of thiorphan and epithelium removal on contractions and tachykinin release produced by activation of capsaicin-sensitive afferents in the guinea-pig isolated bronchus

scientific article published on 01 January 1990

Thermal and electrochemical decomposition of lithium peroxide in non-catalyzed carbon cathodes for Li-air batteries.

scientific article published on 28 May 2013

alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.

scientific article

List of works by Stefania Meini

A different molecular interaction of bradykinin and the synthetic agonist FR190997 with the human B2 receptor: evidence from mutational analysis

A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers

Agonist Activity at the Kinin B1 Receptor: Structural Requirements of the Central Tetrapeptide

Ala scan analogues of HOE 140. Synthesis and biological activities

Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation

Antagonist profile of ibodutant at the tachykinin NK(2) receptor in guinea pig isolated bronchi

Arachidonic acid-induced bronchomotor responses are partially mediated by release of sensory neuropeptides from capsaicin-sensitive structures.

Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant

Bradykinin B2 and GPR100 receptors: a paradigm for receptor signal transduction pharmacology

Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus.

Bradykinin and B2 receptor antagonism in rat and human articular chondrocytes ⬇️

Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers.

Calcitonin gene related peptide as inhibitory neurotransmitter in the ureter.

Capsaicin desensitization selectively inhibits lipoxin A4-induced contraction in guinea pig bronchus

Capsaicin pretreatment does not alter rat urinary bladder motor responses induced by a kinin B1 receptor agonist after endotoxin treatment

Cardiovascular effects of peptide kinin B2 receptor antagonists in rats

Characterization of bradykinin B(2) receptor antagonists in human and rat urinary bladder

Characterization of ibodutant at NK(2) receptor in human colon.

Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Characterization of the tachykinin NK2 receptor in the human bronchus: influence of amastatin-sensitive metabolic pathways

Cinnamic acids and mono-substituted benzoic acids as useful capping groups for the preparation of hNK2 receptor antagonists

Comparative antagonist pharmacology at the native mouse bradykinin B2 receptor: radioligand binding and smooth muscle contractility studies.

Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon.

Contractile effect of endothelin on isolated iris sphincter muscle of the pig.

Design and synthesis of novel sulfonamide-containing bradykinin hB(2) receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine.

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 2. Synthesis and structure-activity relationships of alpha,alpha-cycloalkylglycine sulfonamides.

Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized Guinea pigs.

Differences in electromechanical coupling between bradykinin and the nonpeptide kinin B2 receptor agonist, FR 190997, in the circular muscle of guinea-pig colon.

Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists

Effect of dexamethasone on cyclophosphamide-induced cystitis in rats: lack of relation with bradykinin B1 receptor-mediated motor responses

Effect of iloprost on plasma asymmetric dimethylarginine and plasma and platelet serotonin in patients with peripheral arterial occlusive disease

Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum

Effects of capsaicin, tachykinins, calcitonin gene-related peptide and bradykinin in the pig iris sphincter muscle

Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation.

Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum

Exploring the binding ability of phenanthroline-based polyammonium receptors for anions: hints for design of selective chemosensors for nucleotides.

Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease.

Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes

GR 73,632 and [Glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder.

Iloprost treatment reduces TNF-alpha production and TNF-RII expression in critical limb ischemia patients without affecting IL6.

In vitro and in vivo activity of analogues of the kinin B2 receptor antagonist MEN1 1270.

In vivo effects of neurokinin B on rat urinary bladder motility: Involvement of tachykinin NK1 and NK2 receptors

In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon

Inflammation modifies the role of cyclooxygenases in the contractile responses of the rat detrusor smooth muscle to kinin agonists.

Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor

Interactions between sensory neuropeptides and lipid mediators in the airways.

Isbufylline, a xanthine derivative, inhibits bronchoconstrictor responses produced by stimulation of capsaicin-sensitive sensory nerves in guinea-pig: 'In vitro' and 'in vivo' evidence.

Kinin B1 receptor-mediated motor responses in normal or inflamed rat urinary bladder in vivo

Knee osteoarthritis: a role for bradykinin?

Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor

MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors.

MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist

MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.

MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs

Modulation on C- and N-terminal moieties of a series of potent and selective linear tachykinin NK(2) receptor antagonists

Monocyclic human tachykinin NK-2 receptor antagonists as evolution of a potent bicyclic antagonist: QSAR and site-directed mutagenesis studies

Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 rec

Mutagenesis at the human tachykinin NK(2) receptor to define the binding site of a novel class of antagonists

New conformationally homogeneous beta-turn antagonists of the human B2 kinin receptor

New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide

New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide

Nitric oxide is the mediator of tachykinin NK3 receptor-induced relaxation in the circular muscle of the guinea-pig ileum

Nociceptin and the micturition reflex.

Nonpeptide antagonists for kinin receptors.

Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts

Peptide and non-peptide bradykinin B2 receptor agonists and antagonists: a reappraisal of their pharmacology in the guinea-pig ileum

Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions

Pharmacologic and neurochemical evidence for the activation of capsaicin-sensitive sensory nerves by lipoxin A4 in guinea pig bronchus.

Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.

Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.

Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells

Pharmacological profile of the novel mammalian tachykinin, hemokinin 1

Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor

Preliminary mutational analysis of the human kinin B2 receptor for nonpeptide antagonist ligands recognition

Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).

Rechargeability of Li–air cathodes pre-filled with discharge products using an ether-based electrolyte solution: implications for cycle-life of Li–air cells

Short-term and long-term effects of one-week treatment with intravenous iloprost in critical limb ischemia patients (Leriche-Fontaine stage III and IV).

Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists