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List of works by Alison E. Ashcroft

5-Methylthiopentose: a new substituent on lipoarabinomannan in Mycobacterium tuberculosis

scientific article published in February 2002

A comparison of the electromechanical properties of structurally diverse proteins by molecular dynamics simulation

scientific article

A comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometry ⬇️

scientific article published on 11 June 2015

A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3. ⬇️

scientific article published on July 2013

Amphipathic polymers enable the study of functional membrane proteins in the gas phase ⬇️

scientific article

Amphipols outperform dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase ⬇️

scientific article

An in vivo platform for identifying inhibitors of protein aggregation ⬇️

scientific article published on 14 December 2015

An in vivo platform to select and evolve aggregation-resistant proteins

scientific article published on 14 April 2020

Analysis of amyloid nanostructures using photo-cross-linking: in situ comparison of three widely used photo-cross-linkers ⬇️

scientific article published on 13 January 2014

Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers ⬇️

scientific article published on 7 May 2015

Capillary filling of miniaturized sources for electrospray mass spectrometry

Changes in protein structure monitored by use of gas-phase hydrogen/deuterium exchange

scientific article

Characterization of Amyloid Oligomers by Electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry (ESI-IMS-MS).

scientific article

Co-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometry ⬇️

scientific article published on 20 April 2004

Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins ⬇️

scientific article published on 12 April 2018

Considerations in experimental and theoretical collision cross-section measurements of small molecules using travelling wave ion mobility spectrometry-mass spectrometry

article

Considering The Advantages and Pitfalls of The Use of Isotopically Labeled Protein Standards for Accurate Protein Quantification ⬇️

scientific article published on 01 December 2011

Control of domain swapping in bovine odorant-binding protein

scientific article

Covalent cross-linking within supramolecular peptide structures

scientific article published on 19 July 2012

Critical concentrations of beta-sheet peptide self-assembly quantified directly by nanoelectrospray ionization mass spectrometry

scientific article published in May 2008

Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation

scientific article

De novo sequencing of short interfering ribonucleic acids facilitated by use of tandem mass spectrometry with ion mobility spectrometry

scientific article published in October 2013

Deciphering drift time measurements from travelling wave ion mobility spectrometry-mass spectrometry studies

scientific article published in January 2009

Defining topological features of membrane proteins by nanoelectrospray ionisation mass spectrometry

scientific article published in February 2010

Determining the topology of virus assembly intermediates using ion mobility spectrometry-mass spectrometry

scientific article published on October 2010

Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry

scientific article published in September 2006

Does either the gastrointestinal peptide PYY or the neuropeptide NPY bind aluminium?

scientific article published in April 2003

Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism

scientific article

Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics ⬇️

scientific article published on 4 November 2007

ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules ⬇️

scientific article published on 22 May 2015

Effect of sequence variation on the mechanical response of amyloid fibrils probed by steered molecular dynamics simulation

scientific article published on 7 February 2012

Effects of Periplasmic Chaperones and Membrane Thickness on BamA-Catalyzed Outer-Membrane Protein Folding ⬇️

scientific article published on 15 September 2017

Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

scientific article

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo ⬇️

scientific article

Engineering thermal stability in RNA phage capsids via disulphide bonds

scientific article published on December 2005

Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion ⬇️

scientific article

Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors

scientific article published on 17 January 2013

FPOP-LC-MS/MS Suggests Differences in Interaction Sites of Amphipols and Detergents with Outer Membrane Proteins ⬇️

scientific article

HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta(2)-microglobulin upon release from the MHC-1.

scientific article published on 17 October 2008

Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin ⬇️

scientific article published on 11 April 2017

Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1. ⬇️

scientific article published on 29 August 2017

Inducing protein aggregation by extensional flow ⬇️

scientific article published on 17 April 2017

Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry ⬇️

scientific article

Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry ⬇️

scientific article

Insights into virus capsid assembly from non-covalent mass spectrometry

scientific article

Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

scientific article published on 01 May 2020

Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS. ⬇️

scientific article published on 8 May 2017

Investigating the structural properties of amyloid-like fibrils formed in vitro from beta2-microglobulin using limited proteolysis and electrospray ionisation mass spectrometry

scientific article published in January 2006

Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors ⬇️

scientific article

Large-scale production and structural and biophysical characterizations of the human hepatitis B virus polymerase

scientific article published on 18 December 2013

Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM. ⬇️

scientific article

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein ⬇️

scientific article published on 28 August 2011

Long-Range Conformational Changes in Monoclonal Antibodies Revealed Using FPOP-LC-MS/MS

scientific article published on 13 November 2019

Mass spectrometric methods to analyze the structural organization of macromolecular complexes

scientific article published on 14 March 2015

Mass spectrometry and the amyloid problem--how far can we go in the gas phase?

scientific article published on 9 March 2010

Mechanisms of parasite-induced sex reversal in Gammarus duebeni

scientific article

Metals accelerate the formation and direct the structure of amyloid fibrils of NAC.

scientific article published in September 2005

Molecular dissection of membrane-transport proteins: mass spectrometry and sequence determination of the galactose-H+ symport protein, GalP, of Escherichia coli and quantitative assay of the incorporation of [ring-2-13C]histidine and (15)NH(3).

scientific article

Molecular dynamics simulations of mechanical failure in polymorphic arrangements of amyloid fibrils containing structural defects ⬇️

scientific article published on 04 July 2013

Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry

scientific article published on 2 October 2007

Monitoring oligomer formation from self-aggregating amylin peptides using ESI-IMS-MS

Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions

scientific article

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

scientific article published on 11 June 2012

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization ⬇️

scientific article

On the quaternary association of the type III secretion system HrcQB-C protein: experimental evidence differentiates among the various oligomerization models

scientific article published in May 2009

Probing bunyavirus N protein oligomerisation using mass spectrometry

scientific article published on April 2014

Protein and peptide identification: the rôle of mass spectrometry in proteomics ⬇️

scientific article published on April 1, 2003

Protein destabilisation by ruthenium(II) tris-bipyridine based protein-surface mimetics

scientific article published on April 2013

Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives

scientific article

RNA Packing Specificity and Folding during Assembly of the Bacteriophage MS2

scholarly article by Ottar Rolfsson et al published 2008 in Computational and Mathematical Methods in Medicine

RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry

scientific article published on 28 September 2010

Real-time measurement of myosin-nucleotide noncovalent complexes by electrospray ionization mass spectrometry

scientific article published on 4 May 2007

Recent developments in electrospray ionisation mass spectrometry: noncovalently bound protein complexes

scientific article

Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

scientific article

Scanning conformational space with a library of stereo- and regiochemically diverse aminoglycoside derivatives: the discovery of new ligands for RNA hairpin sequences

scientific article

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry ⬇️

scientific article

Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of pilus biogenesis ⬇️

scientific article published on 10 May 2011

Selective protein-surface sensing using ruthenium(II) tris(bipyridine) complexes

scientific article published on January 2010

Separation of beta2-microglobulin conformers by high-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to electrospray ionisation mass spectrometry

scientific article published in January 2004

Skp is a multivalent chaperone of outer-membrane proteins ⬇️

scientific article published on 25 July 2016

Small molecule probes of protein aggregation ⬇️

scientific article

Structural analysis of Bacillus subtilis SPP1 phage helicase loader protein G39P

scientific article (publication date: 25 April 2003)

Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF

scientific article

Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies ⬇️

scientific article

Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly

scientific article published on September 2011

Synthesis, characterization and applications of a perdeuterated amphipol

scientific article

Systematic analysis of the use of amphipathic polymers for studies of outer membrane proteins using mass spectrometry ⬇️

scientific article

The dhnA gene of Escherichia coli encodes a Class I fructose bisphosphate aldolase ⬇️

scientific article published on April 15, 1998

The effect of dimethylbiguanide on thrombin activity, FXIII activation, fibrin polymerization, and fibrin clot formation

scientific article published in January 2002

The feeding tube of cyst nematodes: characterisation of protein exclusion ⬇️

scientific article published on 28 January 2014

The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry

scientific article

The impact of viral RNA on assembly pathway selection

scientific article published in June 2010

The opening of the SPP1 bacteriophage tail, a prevalent mechanism in Gram-positive-infecting siphophages

scientific article published on 26 May 2011

The role of chaperone-subunit usher domain interactions in the mechanism of bacterial pilus biogenesis revealed by ESI-MS.

scientific article

The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH. ⬇️

scientific article published in August 2012

The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards

scientific article published on 18 July 2013

The use of electrospray mass spectrometry to determine speciation in a dynamic combinatorial library for anion recognition ⬇️

scientific article

Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein

scientific article

Topological Dissection of the Membrane Transport Protein Mhp1 Derived from Cysteine Accessibility and Mass Spectrometry ⬇️

scientific article published on 20 July 2017

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

scientific article

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers ⬇️

scientific article published on 9 May 2017

Understanding quinone cofactor biogenesis in methylamine dehydrogenase through novel cofactor generation

scientific article published in March 2003

Unraveling lactococcal phage baseplate assembly by mass spectrometry

scientific article published on 06 June 2011

Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry ⬇️

scholarly article

Using hydroxyl radical footprinting to explore the free energy landscape of protein folding. ⬇️

scientific article

Using ion mobility spectrometry-mass spectrometry to decipher the conformational and assembly characteristics of the hepatitis B capsid protein ⬇️

scientific article published on September 2013

Viral genomic single-stranded RNA directs the pathway toward a T=3 capsid

scientific article

Widespread, routine occurrence of pharmaceuticals in sewage effluent, combined sewer overflows and receiving waters ⬇️

scientific article

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