Search filters

List of works by Marc Remke

ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma ⬇️

scientific article published on 04 October 2013

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents

scientific article

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

scientific article published on 01 September 2018

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

scientific article published on 25 November 2012

Accumulation of genomic aberrations during clinical progression of medulloblastoma

scientific article published on 15 August 2008

Accumulation of protoporphyrin IX in medulloblastoma cell lines and sensitivity to subsequent photodynamic treatment

scientific article published on 07 November 2018

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

scientific article published on 17 May 2010

Adult medulloblastoma comprises three major molecular variants.

scientific article

Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors

scientific article published on 15 October 2014

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

scientific article

An epigenetic therapy for diffuse intrinsic pontine gliomas.

scientific article published in December 2014

BI-02FUNCTIONAL CHARACTERIZATION OF NOVEL BIOMARKERS IN SELECTING FOR SUBTYPE SPECIFIC MEDULLOBLASTOMA PHENOTYPES.

scientific article

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

scientific article published on May 2008

BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma

scientific article

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

scientific article

CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION

CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

scientific article

CS-01 * THE PHOSPHORYLATION OF ATOH1 LEADS TO ITS DEGRADATION MEDIATED BY THE E3 UBIQUITIN LIGASE HUWE1 IN GRANULE NEURON PROGENITORS

CS-08SONIC HEDGEHOG SIGNALING PROTECTS ATOH1 FROM DEGRADATION MEDIATED BY THE HECT DOMAIN E3 UBIQUITIN LIGASE HUWE1 IN CEREBELLAR GRANULE NEURON PROGENITORS.

scientific article published in November 2014

CS-16 * THE eEF2 KINASE IS CRITICAL FOR BRAIN TUMOURS ADAPTATION TO METABOLIC STRESS

CSIG-15. PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSIS OF HUMAN MEDULLOBLASTOMA REVEALS DISTINCT ACTIVATED PATHWAYS BETWEEN SUBGROUPS

Can miRNA-based real-time PCR be used to classify medulloblastomas?

scientific article published in May 2014

Characterization of a clival chordoma xenograft model reveals tumor genomic instability

Characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes.

scientific article published on 20 October 2015

Clinical implications of medulloblastoma subgroups: incidence of CSF diversion surgery

scientific article published on 19 December 2014

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

scientific article

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

scientific article published on 19 June 2009

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis

scientific article

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

scientific article

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent

scientific article published on 25 February 2014

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target

scientific article

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

scientific article

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Epigenetic Silencing of DKK3 in medulloblastoma.

scientific article published on 8 April 2013

Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma

scientific article published on 17 December 2013

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

scientific article

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

scientific article published on 17 December 2016

Evasion of Cell Senescence Leads to Medulloblastoma Progression

scientific article

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

scientific article published in July 2014

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

scientific article

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

scientific article published on 21 April 2010

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

scientific article

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

scientific article published on 25 July 2011

Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.

scientific article published on 8 December 2013

G-protein coupled receptor expression patterns delineate medulloblastoma subgroups

scientific article

GE-09COMBINED HEREDITARY AND SOMATIC MUTATIONS OF REPLICATION ERROR REPAIR GENES RESULT IN RAPID ONSET OF ULTRA-HYPERMUTATED MALIGNANT BRAIN TUMORS IN CHILDREN.

scientific article published on 21 April 2015

GE-27THERAPEUTIC IMPLICATIONS OF MEDULLOBLASTOMA SUBGROUPS IN CHILDREN OVER AGE 3: A SINGLE CENTRE POPULATION BASED EXPERIENCE.

scientific article published in November 2014

GE-28INTEGRATED GENOMICS DEMONSTRATE RELATIVE SPATIAL HOMOGENEITY IN PEDIATRIC BRAIN TUMORS.

scientific article published in November 2014

Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma

scientific article published on 23 September 2014

Generation of neuronal progenitor cells in response to tumors in the human brain

scientific article published in January 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

scientific article published on 22 April 2010

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

scientific article published on 30 April 2009

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

scientific article published in PLoS ONE

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.

scientific article

Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors.

scientific article

Intertumoral and intratumoral heterogeneity as a barrier for effective treatment of medulloblastoma.

scientific article published on August 2013

LG-01BRAF MUTATION AND CDKN2A DELETION DEFINE A CLINICALLY DISTINCT SUBGROUP OF CHILDHOOD SECONDARY HIGH-GRADE GLIOMA.

scientific article published on 21 April 2015

MB-02SONIC HEDGEHOG INDUCES YB-1 IN A YAP-DEPENDENT MANNER TO REGULATE Igf2 EXPRESSION AND PROLIFERATION IN CEREBELLAR GRANULE NEURON PROGENITORS AND MEDULLOBLASTOMA CELLS.

scientific article published on 21 April 2015

MB-03FUNCTIONAL CHARACTERIZATION OF NOVEL BIOMARKERS IN SELECTING FOR SUBTYPE SPECIFIC MEDULLOBLASTOMA PHENOTYPES.

scientific article published on 21 April 2015

MB-18POST-TRANSLATIONAL REGULATION OF ATOH1: FROM CEREBELLAR DEVELOPMENT TO MEDULLOBLASTOMA FORMATION.

scientific article published on 21 April 2015

MB-21INTEGRATED GENOMICS ELUCIDATES RELATIVE SPATIAL HOMOGENEITY OF EMBRYONAL BRAIN TUMORS.

scientific article published on 21 April 2015

MB-36WIP1 AUGMENTS SONIC HEDGEHOG (SHH) SIGNALING AND IS A TARGET IN SHH MEDULLOBLASTOMAS.

scientific article published on 21 April 2015

MB-53hTERT EXPRESSION AND REGULATION IN PEDIATRIC MEDULLOBLASTOMA (MB).

scientific article published on 30 May 2016

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties

scientific article published on 17 February 2016

MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA

METASTASIS AND TUMOR RECURRENCE FROM RARE SOX9-POSITIVE CELLS IN MYCN-DRIVEN MEDULLOBLASTOMA.

scientific article published in July 2014

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

MRI surrogates for molecular subgroups of medulloblastoma.

scientific article published on 15 May 2014

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.

scientific article published on 22 November 2013

Medulloblastoma molecular dissection: the way toward targeted therapy

scientific article

Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?

scientific article

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

scientific article published on 2 December 2011

Molecular staging of intracranial ependymoma in children and adults

scientific article published in June 2010

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

scientific article

Molecular subgroups of medulloblastoma: the current consensus

scientific article

Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas

scientific article published on May 2015

Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression

scientific article published on 24 July 2013

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes.

scientific article

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome

scientific article published in July 2009

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

scientific article published on 20 March 2011

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

scientific article (publication date: April 2009)

PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS

scientific article published on 6 November 2017

PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article

Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma

scientific article

Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion

scientific article

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

scientific article

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

scientific article published on 11 March 2016

Proteomic analyses of CSF aimed at biomarker development for pediatric brain tumors

scientific article published on 26 April 2014

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

scientific article published on 19 June 2014

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

scientific article published on 21 August 2020

Reduced neorectal capacitance is a more important factor for impaired defecatory function after rectal resection than the anal sphincter pressure

scientific article published on 27 January 2009

Reply to J.C. Lindsey et al

Response

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

scientific article published on 4 April 2016

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

scientific article published on 14 May 2013

Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma

scientific article

SG-04THE eEF2 KINASE, A MEDIATOR OF MEDULLOBLASTOMA ADAPTATION TO METABOLIC STRESS, SUPPORTS FATTY ACID OXIDATION.

scientific article published on 21 April 2015

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

scientific article

Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups

scientific article published on 28 October 2013

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma

scientific article published on 16 May 2013

Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

scientific article

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas

scientific article

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

THOR METHYLATION PROVIDES INSIGHT INTO THE TELOMERE MAINTENANCE LANDSCAPE OF MALIGNANT GLIOMAS.

scientific article published in July 2014

TM-05PTEN INDUCED KINASE1 (PINK1) NEGATIVELY REGULATES AEROBIC GLYCOLYSIS IN GLIOBLASTOMA.

scientific article published in November 2014

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

scientific article

Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.

scientific article published on 25 September 2013

Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

scientific article

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

scientific article

The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis

scientific article

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

scientific article published on 07 December 2018

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

scientific article published on 25 September 2014

The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants

scientific article

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

scientific article

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Treatment developments and the unfolding of the quality of life discussion in childhood medulloblastoma: a review

scientific article

WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma

scientific article published on 18 April 2016

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

scientific article

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

scientific article published on 4 January 2016

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

scientific article published in 2024

Paulina is supported by:

About Paulina

Help