List of works - Nicol Keith

'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract.

scientific article

A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds

scientific article

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

scientific article

A multi-targeted approach to suppress tumor-promoting inflammation

scientific article

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

scientific article

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

scientific article published in January 2009

A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice

scientific article published in June 2012

A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

scientific article published on 6 February 2009

An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects

scientific article

Application of targeted radiotherapy/gene therapy to bladder cancer cell lines.

scientific article published on February 2005

Broad targeting of angiogenesis for cancer prevention and therapy

scientific article

Broad targeting of resistance to apoptosis in cancer.

scientific article

Cancer cell senescence: a new frontier in drug development.

scientific article published on 31 January 2012

Cancer prevention and therapy through the modulation of the tumor microenvironment

scientific article published on 09 April 2015

Cancer stem cells: opportunities for novel diagnostics and drug discovery

scientific article published on 19 April 2006

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

scientific article

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies.

scientific article

Dynamic telomerase gene suppression via network effects of GSK3 inhibition

scientific article

Dysregulated expression of the major telomerase components in leukaemic stem cells.

scientific article published on March 2005

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

scientific article published on 08 January 2007

Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.

scientific article published on 13 March 2007

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

scientific article

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia

scientific article

From stem cells to cancer: balancing immortality and neoplasia

scientific article published in June 2004

Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation.

scientific article published in July 2004

Genetic analysis of drug resistance by fluorescence in situ hybridization.

scientific article

Genetic analysis of drug resistance by reverse in situ hybridization.

scientific article

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.

scientific article

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

scientific article published on September 2015

Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias.

scientific article

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

scientific article published on 25 March 2015

Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.

scientific article published on February 2003

Isolation, culture, and transfection of melanocytes

scientific article published on 03 June 2014

Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters.

scientific article published on September 2005

Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm.

scientific article published in May 2005

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

scientific article (publication date: February 2014)

Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma.

scientific article

Modulation of gene expression using zinc finger-based artificial transcription factors

scientific article published on 01 January 2010

Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.

scientific article published on February 2007

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

scientific article published on January 2015

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients

scientific article published on 12 July 2005

Progeroid syndromes: models for stem cell aging?

scientific article

Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.

scientific article

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival [...]

scientific article

Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.

scientific article published on 27 July 2007

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

scientific article

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells

scientific article published on 01 July 2008

Stem cell ageing: does it happen and can we intervene?

scientific article

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

scientific article

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors.

scientific article published on September 2005

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.

scientific article published on February 2011

Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell

scientific article published in January 2006

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

scientific article

The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma

scientific article published in August 2009

Therapeutic targeting of replicative immortality

scientific article

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

scientific article published on 09 April 2015

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

scientific article published on February 2006

Why a Special Issue on Gene Therapy?

scientific article

List of works by Nicol Keith

'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract.

A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

A multi-targeted approach to suppress tumor-promoting inflammation

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice

A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects

Application of targeted radiotherapy/gene therapy to bladder cancer cell lines.

Broad targeting of angiogenesis for cancer prevention and therapy

Broad targeting of resistance to apoptosis in cancer.

Cancer cell senescence: a new frontier in drug development.

Cancer prevention and therapy through the modulation of the tumor microenvironment

Cancer stem cells: opportunities for novel diagnostics and drug discovery

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies.

Dynamic telomerase gene suppression via network effects of GSK3 inhibition

Dysregulated expression of the major telomerase components in leukaemic stem cells.

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia

From stem cells to cancer: balancing immortality and neoplasia

Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation.

Genetic analysis of drug resistance by fluorescence in situ hybridization.

Genetic analysis of drug resistance by reverse in situ hybridization.

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias.

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.

Isolation, culture, and transfection of melanocytes

Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters.

Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm.

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma.

Modulation of gene expression using zinc finger-based artificial transcription factors

Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients

Progeroid syndromes: models for stem cell aging?

Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival [...]

Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells

Stem cell ageing: does it happen and can we intervene?

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors.

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.

Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma

Therapeutic targeting of replicative immortality

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

Why a Special Issue on Gene Therapy?