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List of works by Timothy A. Ryan

A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis.

scientific article published on 17 September 2009

A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses

scientific article

A pre-synaptic to-do list for coupling exocytosis to endocytosis.

scientific article published on 27 June 2006

A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis

scientific article

A system for performing high throughput assays of synaptic function

scientific article

Actin has a molecular scaffolding, not propulsive, role in presynaptic function

scientific article published in February 2003

Activity-driven local ATP synthesis is required for synaptic function.

scientific article

Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals

scientific article published on 30 January 2017

Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals

scientific article

CDK5 serves as a major control point in neurotransmitter release.

scientific article published on September 2010

Calbindin controls release probability in ventral tegmental area dopamine neurons ⬇️

scientific article published on June 1, 2012

Calcium accelerates endocytosis of vSNAREs at hippocampal synapses

scientific article published in February 2001

Calcium control of endocytic capacity at a CNS synapse

scientific article published in June 2008

Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals

scientific article published on 30 October 2014

Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice

scientific journal article

Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

scientific article published on 30 July 2013

Fluorescent proteins with ties that bind

scientific article published on 01 December 2003

Highly cooperative control of endocytosis by clathrin

scientific article

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division

scientific article published on 15 November 2017

Imaging [Ca2+]i dynamics during signal transduction.

scientific article published on February 1990

Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

scientific article

Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca2.1 and Ca2.2 in Rat Midbrain Neurons

scientific article published on 24 January 2019

Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling

scientific article

Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I

scholarly article

Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons.

scientific article published on June 2009

Modes of vesicle retrieval at ribbon synapses, calyx-type synapses, and small central synapses

scientific article published on October 2007

Molecular circuitry of endocytosis at nerve terminals.

scientific article published on January 2009

Munc13 marks the spot

scientific article published on 21 December 2017

Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons

scientific article published on 25 January 2005

Neural activity controls the synaptic accumulation of alpha-synuclein.

scientific article published in November 2005

Neuronal protein economics: keeping tabs on synthesis.

scientific article published in July 2010

New insights into molecular players involved in neurotransmitter release.

scientific article published on February 2012

Optical detection of a quantal presynaptic membrane turnover

scientific article published in July 1997

Optical mapping of release properties in synapses ⬇️

scientific article published on August 12, 2010

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.

scientific article

Potentiation of evoked vesicle turnover at individually resolved synaptic boutons

scientific article published in July 1996

Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system.

scientific article published in April 2000

Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons

scientific article published in May 2002

Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode

scholarly article

Synapsin dispersion and reclustering during synaptic activity

scientific article published in December 2001

Synaptic activity regulates the abundance and binding of complexin

scientific article

Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies

scientific article published in April 2003

Synaptic vesicle recycling at CNS snapses without AP-2

scientific journal article

Synaptic vesicle retrieval time is a cell-wide rather than individual-synapse property.

scientific article published on 29 May 2011

Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling

scientific article published on 01 July 2006

Syntaxin-1A is excluded from recycling synaptic vesicles at nerve terminals.

scientific article published in May 2004

Targeted chemical disruption of clathrin function in living cells.

scientific article published on 07 August 2003

The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels

scientific article published on 21 July 2015

The control of release probability at nerve terminals

scientific article published on 01 March 2019

The efficiency of the synaptic vesicle cycle at central nervous system synapses.

scientific article published on 12 July 2006

The general anesthetic isoflurane depresses synaptic vesicle exocytosis.

scientific article

The kinetics of synaptic vesicle pool depletion at CNS synaptic terminals

scientific article published in March 2004

The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals.

scientific article published in February 2006

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons

scientific article published in October 1993

The synaptic vesicle: cycle of exocytosis and endocytosis.

scientific article

Vesicle pool mobilization during action potential firing at hippocampal synapses.

scientific article published in May 1995

Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling

scientific article

Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion

scientific article

Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex

scientific article

α2δ expression sets presynaptic calcium channel abundance and release probability

scientific article published on 13 May 2012

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