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List of works by Johan Van Der Vlag

1,25-Vitamin D3 Deficiency Induces Albuminuria

scientific article published on 03 February 2016

A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx

scientific article

A microscopic view on the renal endothelial glycocalyx.

scientific article

A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis

scientific article published on 01 November 2004

Aberrant heparan sulfate profile in the human diabetic kidney offers new clues for therapeutic glycomimetics

scientific article published on 01 August 2006

Acetylated Histones in Apoptotic Microparticles Drive the Formation of Neutrophil Extracellular Traps in Active Lupus Nephritis.

scientific article published on 14 September 2017

Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus

scientific article published on 01 January 2015

Adult and paediatric patients with minimal change nephrotic syndrome show no major alterations in glomerular expression of sulphated heparan sulphate domains

scientific article published on 25 May 2007

Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype.

scientific article

An absolute procedure to test the growth potential of medium and the influence of decreased oxygen tension in primary amniotic fluid cell cultures

scientific article published in September 2006

Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.

scientific article

Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy

scientific article published on 01 February 2005

Apoptosis and NET formation in the pathogenesis of SLE.

scientific article published on 17 September 2012

Apoptosis in the pathogenesis of systemic lupus erythematosus.

scientific article published on May 2008

Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodies

scientific article published on 10 September 2009

Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus

scientific article published on 01 June 2007

Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus

scientific article published on 10 August 2010

Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K.

scientific article

Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?

scientific article published on 21 November 2007

Association of kidney function with changes in the endothelial surface layer.

scientific article published on 23 January 2014

Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote

scientific journal article

Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy.

scientific article

Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals

scientific article

Both early and late apoptotic blebs are taken up by DC and induce IL-6 production

scientific article published on 01 May 2009

Breaking immunological tolerance in systemic lupus erythematosus.

scientific article published on 09 April 2014

C3 glomerulopathy - understanding a rare complement-driven renal disease

scientific article published on 01 March 2019

CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis

scientific article published on 21 December 2017

CRP/anti-CRP antibodies assembly on the surfaces of cell remnants switches their phagocytic clearance toward inflammation.

scientific article published on 2 December 2011

Characterization of anticoagulant heparinoids by immunoprofiling

scientific article

Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

scientific article

Chromatin remodelling initiation in spermatids: differences among human males

scientific article published on 28 March 2013

Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation.

scientific article published on 21 January 2007

Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis

scientific article published on 01 February 2016

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation

scientific article published on 17 August 2018

Control and regulation of metabolic fluxes in microbes by substrates and enzymes

scientific article published in January 1993

Control of glucose metabolism by the enzymes of the glucose phosphotransferase system in Salmonella typhimurium

scientific article published in May 1995

Cracking the pathogenesis of cocaine-induced vasculitis

scientific article published on 01 April 2017

Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion

scientific article (publication date: 2014)

Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness.

scientific article published in May 2006

Deranged removal of apoptotic cells: its role in the genesis of lupus.

scientific article

Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology

scientific article published on 31 August 2015

Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy.

scientific article

Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus

scientific article

Early Apoptotic Reorganization of Spliceosomal Proteins Involves Caspases, CAD and Rearrangement of NuMA ⬇️

scientific article published on November 23, 2011

Early development of hyperparathyroidism due to loss of PTH transcriptional repression in patients with HNF1β mutations?

scientific article published on 26 August 2013

Effect of administration of apoptotic blebs on disease development in lupus mice

scientific article published on 02 April 2012

Effect of long-term storage of urine samples on measurement of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL).

scientific article published on 21 November 2013

Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria

scientific article

Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice

scientific article published on 16 April 2015

Epigenetic patterns maintained in early Caenorhabditis elegans embryos can be established by gene activity in the parental germ cells

scientific article (publication date: June 2011)

Expression of glomerular heparan sulphate domains in murine and human lupus nephritis.

scientific article published on 5 June 2007

Expression of sialidase and dystroglycan in human glomerular diseases

scientific article published on 15 September 2009

Glomerular endothelial surface layer acts as a barrier against albumin filtration.

scientific article published on 19 March 2013

Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.

scientific article published on 13 April 2014

Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking.

scientific article

Heparan sulfate on activated glomerular endothelial cells and exogenous heparinoids influence the rolling and adhesion of leucocytes.

scientific article published on 25 January 2007

Heparan sulfate proteoglycans in glomerular inflammation.

scientific article published on March 2004

Heparanase Accelerates Obesity-Associated Breast Cancer Progression

scientific article published on 03 September 2019

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

article

Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy

scientific article published on 06 December 2007

Heparanase is essential for the development of diabetic nephropathy in mice.

scientific article published on 21 November 2011

Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease

scientific article published on 6 February 2017

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury

scientific article

Improvement in chromatin maturity of human spermatozoa selected through density gradient centrifugation

scientific article published on 01 June 2011

In vivo degradation of heparan sulfates in the glomerular basement membrane does not result in proteinuria

scientific article published on 24 January 2007

Incomplete nuclear transformation of human spermatozoa in oligo-astheno-teratospermia: characterization by indirect immunofluorescence of chromatin and thiol status

scientific article published on 30 November 2007

Increased expression of heparanase in overt diabetic nephropathy

scientific article published on 18 October 2006

Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy.

scientific article published on 24 August 2015

Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.

scientific article

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis

scientific article published on 22 May 2020

Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis ⬇️

scientific article published on October 1, 1997

Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37-deficient mice

scientific article published on 15 March 2018

Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation

scientific article published on 8 June 2017

Ligation of alpha-dystroglycan on podocytes induces intracellular signaling: a new mechanism for podocyte effacement?

scientific article

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice.

scientific article published on 15 December 2017

Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies.

scientific article published on 23 March 2005

Localization of alpha-dystroglycan on the podocyte: from top to toe.

scientific article published on 13 June 2005

Lupus-derived monoclonal autoantibodies against apoptotic chromatin recognize acetylated conformational epitopes

scientific article published on 01 November 2010

Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis

scientific article published on 23 April 2014

Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa

scientific article published on 16 June 2013

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro

scientific article published on 4 January 2016

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome

scientific article

Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens

scientific article published on 19 January 2011

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps.

scientific article published on 4 November 2016

New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis.

scientific article published on 4 January 2013

New approaches to the treatment of dense deposit disease

scientific article published on 5 August 2007

Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

scientific article published on 19 August 2011

Proteasome inhibition: a new therapeutic option in lupus nephritis?

scientific article published on 22 September 2008

Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration

scientific article published on April 2013

RNA Contaminates Glycosaminoglycans Extracted from Cells and Tissues

scientific article

Reactive oxygen species deglycosilate glomerular alpha-dystroglycan.

scientific article published in May 2006

Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria

scientific article published on 28 November 2007

Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species.

scientific article

Regulation of glycerol and maltose uptake by the IIAGlc-like domain of IINag of the phosphotransferase system inSalmonella typhimurium LT2 ⬇️

scientific article published on July 28, 1995

Regulatory and pathogenetic mechanisms of autoantibodies in SLE.

scientific article published on 14 January 2011

Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study

scientific article published on 14 October 2009

Removal of heparan sulfate from the glomerular basement membrane blocks protein passage.

scientific article published on 14 November 2007

Role of heparanase-driven inflammatory cascade in pathogenesis of diabetic nephropathy

scientific article published on 9 July 2014

Role of syndecan-1 in the interaction between dendritic cells and T cells

scientific article published on 23 July 2020

Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity

scientific article published in April 2009

Selection and characterization of a unique phage display-derived antibody against dermatan sulfate

scientific article published on 30 June 2006

Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity

scientific article published on 27 April 2018

Sperm-derived histones contribute to zygotic chromatin in humans.

scientific article

Synchronized turbo apoptosis induced by cold-shock

scientific article published on January 2011

Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis

scientific article published on 05 September 2007

TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy

scientific article

The endothelial glycocalyx as a potential modifier of the hemolytic uremic syndrome

scientific article

The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.

scientific article

The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases

scientific article published on 20 September 2014

The role of heparanase and the endothelial glycocalyx in the development of proteinuria

scientific article published on 28 October 2013

The role of reactive oxygen species in apoptosis of the diabetic kidney.

scientific article published on December 2009

The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two.

scientific article published in March 1993

The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology

scientific article

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

scientific article (publication date: December 1999)

Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin.

scientific article published on 7 July 2006

Urinary MicroRNA as Biomarker in Renal Transplantation.

scientific article published on 15 October 2016

Urinary heparanase activity in patients with Type 1 and Type 2 diabetes

scientific article published on 20 December 2011

Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice

scientific article published on 06 February 2008

Vascular endothelial growth factor in systemic capillary leak syndrome.

scientific article

Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte

scientific article published on 23 July 2015

Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease

scientific article published on 04 February 2013

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