List of works - Kazuya Shimura

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

scientific article

CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV.

scientific article published in November 2012

Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat

scientific article

Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents

scientific article published on 30 January 2013

Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles

scientific article

Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182.

scientific article published on 16 January 2013

Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20

scientific article published on 10 December 2008

HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains

scientific article published on 20 May 2013

Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold

scientific article published on 16 February 2015

Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread

scientific article published on 14 July 2015

Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds

scientific article published on April 2015

Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design

scientific article

Potent CXCR4 antagonists containing amidine type Peptide bond isosteres

scientific article published on 28 March 2011

Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors

scientific article

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

scientific article published on 19 June 2013

Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents

scientific article

Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide

scientific article

List of works by Kazuya Shimura

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV.

Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat

Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents

Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles

Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182.

Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20

HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains

Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold

Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread

Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds

Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design

Potent CXCR4 antagonists containing amidine type Peptide bond isosteres

Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents

Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide