List of works - Stephen J. Ralph

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression

scientific article published on April 2007

A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases ⬇️

scientific article published on May 5, 1992

Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

scientific article published on 8 June 2011

An update on malignant melanoma vaccine research: insights into mechanisms for improving the design and potency of melanoma therapeutic vaccines.

scientific article published on January 2007

Anticancer drugs targeting the mitochondrial electron transport chain

scientific article published on September 2011

Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes.

scientific article published on October 1999

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

scientific article published on 21 December 2009

Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway

scientific article published on 23 May 2018

Classification of mitocans, anti-cancer drugs acting on mitochondria

scientific article published on 28 July 2012

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

scientific article published on 29 August 2013

Development of a potent melanoma vaccine capable of stimulating CD8(+) T-cells independently of dendritic cells in a mouse model

scientific article

Enhancing CTL responses to melanoma cell vaccines in vivo: synergistic increases obtained using IFNgamma primed and IFNbeta treated B7-1+ B16-F10 melanoma cells.

scientific article published on December 2003

Erratum to: Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

scholarly article published in Pharmaceutical Research

Future use of mitocans against tumour-initiating cells?

scientific article published on January 2009

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

scientific article

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment.

scientific article published on December 2012

HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.

scientific article published on August 2009

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

scientific article published on 18 January 2011

Human T cell leukemia virus type I tax-induced IκB-ζ modulates tax-dependent and tax-independent gene expression in T cells

scientific article published on September 2013

IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.

scientific article

Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines.

scientific article

Increased All-Cause Mortality by Antipsychotic Drugs: Updated Review and Meta-Analysis in Dementia and General Mental Health Care

scientific article published on 02 February 2018

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

scientific article published on 18 October 2013

Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence

scientific article

Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.

scientific article published on 24 August 2011

Interferon- and virus-inducible gene ISG-60. Map position 10q23.3

scientific article published on December 1, 1997

Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma.

scientific article published on November 1997

Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.

scientific article published on 21 March 2002

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.

scientific article published on February 2007

Mitocans, a class of emerging anti-cancer drugs

scientific article published on 01 January 2009

Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents

scientific article

Mitochondrial respiratory chain inhibitors induce apoptosis

scientific article published in February 1994

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

scientific article

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

scientific article published on 12 March 2011

Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue

scientific article published on 22 May 2012

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

scientific article published on 12 June 2006

Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3.

scientific article

Phase I/II parallel double-blind randomized controlled clinical trial of perispinal etanercept for chronic stroke: improved mobility and pain alleviation

scientific article published on 03 January 2020

REST negatively and ISGF3 positively regulate the human STAT1 gene in melanoma.

scientific article published on 18 April 2013

Reactive oxygen species are generated by the respiratory complex II--evidence for lack of contribution of the reverse electron flow in complex I.

scientific article published on 7 January 2013

Redox state influence on human galectin-1 function.

scientific article

Repurposing drugs as pro-oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers

scientific article published on 20 May 2019

Structural studies of T200 glycoprotein and the IL-2 receptor

scientific article published in January 1987

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

scientific article published on 17 February 2009

The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.

scientific article

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

scientific article published on 02 March 2010

The effect of laser irradiation on proliferation of human breast carcinoma, melanoma, and immortalized mammary epithelial cells

scientific article published in February 2010

The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection.

scientific article published on 3 May 2016

The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection?

scientific article published on 14 June 2011

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

scientific article

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase ⬇️

scientific article published on April 1, 1991

Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors.

scientific article published on January 2013

Use of antipsychotics and benzodiazepines for dementia: Time for action? What will be required before global de-prescribing?

scientific article published in January 2017

Use of cytokines in cancer vaccines/immunotherapy: recent developments improve survival rates for patients with metastatic malignancy.

scientific article

Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress

scientific article published on 01 December 2007

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria

scientific article published on 23 February 2007

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

scientific article published on 07 February 2014

alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

scientific article published in July 2010

List of works by Stephen J. Ralph

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression

A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases ⬇️

Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

An update on malignant melanoma vaccine research: insights into mechanisms for improving the design and potency of melanoma therapeutic vaccines.

Anticancer drugs targeting the mitochondrial electron transport chain

Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes.

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway

Classification of mitocans, anti-cancer drugs acting on mitochondria

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

Development of a potent melanoma vaccine capable of stimulating CD8(+) T-cells independently of dendritic cells in a mouse model

Enhancing CTL responses to melanoma cell vaccines in vivo: synergistic increases obtained using IFNgamma primed and IFNbeta treated B7-1+ B16-F10 melanoma cells.

Erratum to: Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

Future use of mitocans against tumour-initiating cells?

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment.

HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

Human T cell leukemia virus type I tax-induced IκB-ζ modulates tax-dependent and tax-independent gene expression in T cells

IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.

Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines.

Increased All-Cause Mortality by Antipsychotic Drugs: Updated Review and Meta-Analysis in Dementia and General Mental Health Care

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence

Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.

Interferon- and virus-inducible gene ISG-60. Map position 10q23.3

Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma.

Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.

Mitocans, a class of emerging anti-cancer drugs

Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents

Mitochondrial respiratory chain inhibitors induce apoptosis

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3.

Phase I/II parallel double-blind randomized controlled clinical trial of perispinal etanercept for chronic stroke: improved mobility and pain alleviation

REST negatively and ISGF3 positively regulate the human STAT1 gene in melanoma.

Reactive oxygen species are generated by the respiratory complex II--evidence for lack of contribution of the reverse electron flow in complex I.

Redox state influence on human galectin-1 function.

Repurposing drugs as pro-oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers

Structural studies of T200 glycoprotein and the IL-2 receptor

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

The effect of laser irradiation on proliferation of human breast carcinoma, melanoma, and immortalized mammary epithelial cells

The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection.

The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection?

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase ⬇️

Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors.

Use of antipsychotics and benzodiazepines for dementia: Time for action? What will be required before global de-prescribing?

Use of cytokines in cancer vaccines/immunotherapy: recent developments improve survival rates for patients with metastatic malignancy.

Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels