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List of works by Daniel Jun

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.

scientific article published on 10 December 2015

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

scientific article published on 25 May 2016

A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats

scientific article published on 01 June 2007

A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats

scientific article published on 4 May 2008

Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment

scientific article

Acetylcholinesterases--the structural similarities and differences

scientific article published in August 2007

Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis

scientific article published on 29 April 2017

Amperometric Biosensors for Real Time Assays of Organophosphates

scientific article published in September 2008

An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents.

scientific article published on 18 May 2008

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment

scientific article published on 17 March 2020

Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX

scientific article published on 07 July 2006

Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing

scientific article published in November 2005

Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases: an in vitro study

scientific article published in July 2007

Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study

scientific article published on 24 October 2006

Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase

scientific article published in January 2007

Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder.

scientific article published on September 2010

Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.

scientific article published on 11 December 2014

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae).

scientific article published on 14 July 2017

Cholinesterase biosensor construction - a review.

scientific article published on January 2008

Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents

scientific article published in December 2007

Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species

scientific article published in December 2005

Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

scientific article published in July 2005

Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats

scientific article published in November 2007

Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo

scientific article published on 01 December 2005

Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro

scientific article published in January 2007

Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure.

scientific article published on 9 February 2018

DPPH Radical Scavenging Activity of Several Naturally Occurring Coumarins and Their Synthesized Analogs Measured by the SIA Method

scientific article published in January 2008

Daphnia intoxicated by nerve agent tabun can be treated using human antidotes.

scientific article published on 13 November 2007

Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents

scientific article published on 21 April 2005

Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).

scientific article published on 9 October 2007

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

scientific article published on 2 October 2015

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.

scientific article published on 28 July 2017

Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro.

scientific article

Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro

scientific article published in May 2006

Effective bisquaternary reactivators of tabun-inhibited AChE.

scientific article published in November 2005

Efficacy and dosing of antidotes applied to Daphnia intoxicated by nerve agent tabun ⬇️

scientific article published on June 8, 2008

Erratum to “The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain” [Steroids 74(January (1)) (2009) 13–19]

scholarly article published in Steroids

Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae

scientific article published on 01 April 2008

Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency

scientific article published on 01 August 2008

Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents

scientific article published in September 2006

Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by "ferric reducing antioxidant power" assay.

scientific article published on 28 January 2013

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

scientific article published on 19 August 2019

Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process

scientific article published on 12 March 2010

Hyaluronidase: its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs

scientific article published on 25 April 2013

Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators

scientific article published on 17 June 2008

In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases.

scientific article published on January 2008

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

scientific article published on 05 April 2019

In vitro antiplatelet activity of flavonoids from Leuzea carthamoides

scientific article published in January 2008

In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings

scientific article published in January 2006

In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase.

scientific article published in July 2009

In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase

scientific article published in August 2006

In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048.

scientific article published in June 2009

In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions

scientific article published in July 2005

Inhibition of blood cholinesterases following intoxication with VX and its derivatives.

scientific article published in September 2007

Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease.

scientific article

Isoquinoline alkaloids as prolyl oligopeptidase inhibitors.

scientific article published on 9 April 2015

Methylacridinium and its cholinergic properties.

scientific article published on 30 June 2009

Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site of human acetylcholinesterase

scientific article published on 02 November 2018

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.

scientific article published on 10 August 2007

Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase

scientific article published on 20 July 2008

New antioxidant flavonoid isolated from Leuzea carthamoides.

scientific article published in February 2010

New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin

scientific article published in October 2006

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.

scientific article

Novel acetylcholinesterase reactivator K112 and its cholinergic properties.

scientific article published on 2 February 2010

Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon

scientific article published in December 2009

Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

scientific article published on 13 March 2007

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

scientific article published on 12 June 2011

Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.

scientific article published in August 2010

Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.

scientific article published on 5 December 2014

Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation

scientific article published on 01 December 2008

Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin

scientific article

Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases

scientific article

Potency of novel oximes to reactivate sarin inhibited human cholinesterases.

scientific article published on January 2008

Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro

scientific article published on 7 May 2008

Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning

scientific article

Preparation of benzalkonium salts differing in the length of a side alkyl chain

scientific article published on 24 October 2007

Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.

scientific article published on 31 October 2013

Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning

scientific article published on 18 August 2006

Profiling donepezil template into multipotent hybrids with antioxidant properties

scientific article published in December 2018

Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016).

scientific article published on June 2017

Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors

scientific article published on 20 June 2017

Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase

scientific article published on 3 March 2010

RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker

scientific article published on 28 March 2008

Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes

scientific article published on 16 May 2008

Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker.

scientific article published on 17 March 2010

Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127.

scientific article published on 15 May 2009

Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.

scientific article published on April 2006

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.

scientific article

Simple validated method of LC-MS/MS determination of BZ agent in rat plasma samples

scientific article published on 10 January 2020

Simultaneous determination of malondialdehyde and 3-nitrotyrosine in cultured human hepatoma cells by liquid chromatography-mass spectrometry

scientific article published on 21 August 2018

Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy

scientific article published in January 2016

Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase

scientific article published on 14 May 2019

Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts

scientific article published in 2021

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy

scientific article published on 01 December 2019

Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.

scientific article published on 2 December 2010

Synthesis of (2E)-2-methyl-3-(4-([4-(quinolin-2-ylmethoxy)phenyl]sulfanyl)phenyl)prop-2-enoic acid (VUFB 20609) and 2-methyl-3-(4-([4-(quinolin-2-ylmethoxy)phenyl]sulfanyl)phenyl)propanoic acid (VUFB 20584) as potential antileukotrienic agents.

scientific article published on June 2004

Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

scientific article

Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

scientific article published in August 2007

Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

scientific article published on 24 August 2006

Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

scientific article published in January 2008

Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

scientific article

Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety

scientific article published on 6 January 2016

Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids

scientific article published on 07 June 2017

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

scientific article published on 01 December 2020

Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.

scientific article published on 27 October 2015

Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.

scientific article published on 20 August 2007

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

scientific article published on 5 May 2016

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

scientific article published on 13 October 2016

The effect of oxime reactivators on muscarinic receptors: functional and binding examinations

scientific article published on 28 January 2011

The influence of acetylcholinesterase reactivators on selected hepatic functions in rats

scientific article published in August 2008

The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain

scientific article

The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers

scientific article published on 6 June 2012

The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings

scientific article published in September 2006

The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors ⬇️

scientific article published on November 21, 2012

Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX.

scientific article published in November 2009

Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction.

scientific article published on May 2007

Trithiocyanurate complexes of iron, manganese and nickel and their anticholinesterase activity.

scientific article published on 8 April 2014

Two step synthesis of a non-symmetric acetylcholinesterase reactivator

scientific article published on 7 August 2007

Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE

scientific article published on 01 January 2015

Why acetylcholinesterase reactivators do not work in butyrylcholinesterase

scientific article published on June 2010

Soubor přednášek z vojenské farmacie

book edition published in 2021

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