List of works - Fumihiko Hakuno

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts ⬇️

scientific article

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta

scientific article published in October 2008

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

scientific article

Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans

scientific article published on 25 February 2012

Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.

scientific article published on 7 April 2009

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

scientific journal article

Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

scientific article

Insulin receptor substrate-3 functions as transcriptional activator in the nucleus

scientific journal article

Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity

scientific article published on 11 March 2010

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

scientific article published on 17 December 2010

Insulin-Like Growth Factor-l Potentiates Protein Synthesis Induced by Thyrotropin in FRTL-5 Cells: Comparison of Induction of Protein Synthesis and DNA Synthesis ⬇️

scientific article published on April 1, 1998

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

scientific article

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

scientific article published on 14 April 2011

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

scientific article published on January 2004

Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells

scientific article

Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation.

scientific article published on August 2012

Novel repressor regulates insulin sensitivity through interaction with Foxo1

scientific article

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation

scientific article published on 01 August 2012

PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions ⬇️

scientific article published on May 19, 2011

Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.

scientific article

Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells ⬇️

scientific article published on April 11, 2012

Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

scientific article

The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation

scientific article published on 11 March 2013

The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats

scientific article published on 17 August 2006

List of works by Fumihiko Hakuno

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts ⬇️

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans

Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

Insulin receptor substrate-3 functions as transcriptional activator in the nucleus

Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

Insulin-Like Growth Factor-l Potentiates Protein Synthesis Induced by Thyrotropin in FRTL-5 Cells: Comparison of Induction of Protein Synthesis and DNA Synthesis ⬇️

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells

Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation.

Novel repressor regulates insulin sensitivity through interaction with Foxo1

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation

PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions ⬇️

Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.

Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells ⬇️

Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation

The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats